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Books > Professional & Technical > Biochemical engineering > Biotechnology
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New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications (Hardcover, 1st ed. 2021)
Loot Price: R4,632
Discovery Miles 46 320
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New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications (Hardcover, 1st ed. 2021)
Expected to ship within 10 - 15 working days
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This contributed volume applies the insights of supramolecular
chemistry to biomedical applications such as ions/water transport
through nano-scale channels, gene therapy, tissue engineering and
drug delivery, to cite some of the major investigations.The
challenge is to understand the mechanisms of transport through
tissues particularly in the therapeutic treatment of a disease
where the active drug must be delivered directly to diseased cells
without affecting healthy cells. As a result, smaller quantities of
active substances can be used to treat the disease. Another
interest concerns new ways to administer gene therapy. If genes are
often delivered to their target cells by adapted viruses, the
supramolecular non-viral 'vectors' using dynamic nano-frameworks
and nano-structures are presented. In addition, it is important to
reconstruct damaged tissues by mimicking natural processes in cells
and polymers, such as tissue engineering and self-healing.
Different options are here discussed: e.g. hydrogels based on
chitosan, a carbohydrate polymer, are proving especially promising
for tissue engineering and drug delivery. For controlled delivery
of drugs or other biologically active compounds, hydrogels
sensitive to the most important stimuli in the human body, such as
temperature, pH, ionic strength, glucose and biomolecules released
by the organism in pathological conditions have been developed.
Finally, to assist and validate the experimental studies, computer
modelling and simulations of large-sized molecular structures and
systems using different molecular dynamics and quantum mechanical
techniques are developed based on the experimental and chemistry
synthesis. This book is of great interest for graduate students,
researchers and health professionals interested in acquiring a
better understanding of the mechanisms of medical treatments. In
addition, it provides numerous tools to develop better therapies
for human diseases.
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