Neuronal Growth Factors (Paperback, Softcover reprint of the original 1st ed. 1991)

A host of environmental factors regulate the embryonic development of neurons. In adults, the survival of neurons, the regeneration of damaged axons, and plastic changes in axonal arborization are also controlled by a complex array of environmental cues. An important category of regulatory influences involves target-derived hormone-like peptides act ing on neuronal cell surface receptors. Nerve growth factor (NGF) was the first such factor to be characterized (LEVI MONTALCINI and HAMBURGER 1953) and has served as the model against which all similar factors are compared. A number of factors with properties similar to NGF have been described with activities toward differing populations of neurons. Many of these factors have been characterized only poorly at the biochemical level. However, several factors have been charac terized to the extent that molecular clones are available and complete amino acid sequences are known. These include: three structurally related factors, NGF itself (SCOTT et al. 1983), brain-derived neurotrophic factor (BDNF) (LEIBROCK et al. 1989), and neurotrophin-3 (NT-3) (MAISONPIERRE et al. 1990; HOHN et al. 1990); ciliary neurotrophic factor (CNTF) (LIN et al. 1989) and a second set of structural homologs; acidic and basic fibroblast growth factors (aFGF, bFGF) (ABRAHAM et al. 1986; JAYE et al. 1986). Investigators have cloned the receptors for NGF (JOHNSON et al. 1986; RADEKE et al. 1987) and FGF (LEE et al. 1989)."

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Current Topics in Microbiology and Immunology, 165
Release date:	December 2011
First published:	1991
Editors:	Mark Bothwell
Dimensions:	235 x 155 x 10mm (L x W x T)
Format:	Paperback
Pages:	173
Edition:	Softcover reprint of the original 1st ed. 1991
ISBN-13:	978-3-642-75749-5
Categories:	Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > Allergies Promotions
LSN:	3-642-75749-9
Barcode:	9783642757495

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