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The Scid Mouse - Characterization and Potential Uses (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R2,964
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The Scid Mouse - Characterization and Potential Uses (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Current Topics in Microbiology and Immunology, 152
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During routine genetic screening of several immunoglobulin heavy
chain congenic mouse strains in 1980, one of us (MB) was surprised
to find that several mice in the C.B-17IIcr strain, which was being
maintained in a specific-pathogen-free facility of the Fox Chase
Cancer Center (Philadelphia, PA), did not express serum
immunoglobulin of the appropriate allotype. Fearing an error in the
breeding of these mice, the sera of the suspect mice were screened
for other allotypes. When these tests revealed a complete absence
of serum immunoglobulin, it became apparent that a mutation had
probably occurred in the C.B-17IIcr line. Further analysis revealed
that a single breeding pair was respon sible for all of the
immunoglobulin negative mice and that the defect showed recessive
inheritance. Thus was the C.B-17/Icr scid or severe combined immune
deficient (scid) mouse discovered. Although it has taken most
animal facilities several years to breed scid mice of high quality
for experimental purpose, it was clear by 1987 that many
investigators were beginning to exploit the unique qualities of the
scid mouse for studies in several areas.
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