Since the publication of the first edition of Pharmaceutical
Biotechnology over a decade ago, a not-so-subtle shift in the
meaning of the term "biotechnology" has occurred. It has come to
mean something very specific, namely the development of drug
substances with large protein and polypeptide molecules. These
substances can be used as drugs in their own right but may also be
used to manipulate cellular DNA in order to produce a required
molecule that is believed to have desirable properties in the
treatment of a disease. Accordingly, the second edition of this
popular text reflects that change of definition by including new
material that explores the development of these protein-based
therapeutic substances. See what's new in the Second Edition:
-Expanded coverage of the formulation of proteins -Additional
information on proteins used as drug delivery systems -Detailed
discussion of interactions between proteins and phospholipids
-Increased information on proteomics and gene therapy -Exploration
of pulmonary administration and oral delivery of proteins -A broad
review of vaccines -Discussion of genetic engineering and genomics
-Challenges and issues involved in the development and the
production of a drug
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