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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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RNA Therapeutics - Function, Design, and Delivery (Paperback, Softcover reprint of the original 1st ed. 2010)
Loot Price: R2,982
Discovery Miles 29 820
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RNA Therapeutics - Function, Design, and Delivery (Paperback, Softcover reprint of the original 1st ed. 2010)
Series: Methods in Molecular Biology, 629
Expected to ship within 10 - 17 working days
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Central to the synthesis of proteins, the performance of catalysis,
and many other physiological processes, the aberrant expression of
which can be linked to human diseases including cancers, RNA has
proven to be key target for therapeutics as well as a tool for
therapy. In RNA Therapeutics: Function, Design, and Delivery,
expert contributors from a broad spectrum of scientific backgrounds
highlight the roles that messenger RNAs and small RNAs can play in
biology and medicine. While covering the five major RNA-based
drugs, namely the use of ribozymes to cleave and/or correct mRNA
transcript, the use of siRNA for targeted silencing of gene
transcripts, the use of aptamers, like short RNA molecules, for
neutralizing the protein functions, the use mRNA-transfected DCs to
activate immune system against tumor cells, as well as the use of
RNA to reprogram T and/or DC cell function, this extensive volume
brings together the fields of coding (mRNA) and non-coding RNA such
as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient
source. Written in the highly successful Methods in Molecular
Biology (TM) series format, the cutting-edge protocol chapters
contain introductions to their respective topics, lists of the
necessary materials and reagents, step-by-step, readily
reproducible laboratory protocols, and practical tips on
troubleshooting and avoiding known pitfalls. Also, the book
contains several excellent reviews for teaching purposes.
Authoritative and comprehensive, RNA Therapeutics: Function,
Design, and Delivery provides key models and tools which will
assist researchers in increasing our understanding of RNA
functions, modifications, and their involvement in diseases in
order to lead to the design of vital new RNA-based therapeutics.
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