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Mechanisms and Specificity of HIV Entry into Host Cells (Paperback, Softcover reprint of the original 1st ed. 1991)
Loot Price: R2,935
Discovery Miles 29 350
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Mechanisms and Specificity of HIV Entry into Host Cells (Paperback, Softcover reprint of the original 1st ed. 1991)
Series: Advances in Experimental Medicine and Biology, 300
Expected to ship within 10 - 15 working days
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The fIrst reports on the tropism of the human immunodefIciency
virus (HIV), then called human T-celilymphotrophic virus type ill
(HTLY- ill) or lymphadenopathy associated virus (LA V), indicated
an almost absolute specifIcity of the virus for T4 (helper/inducer)
lymphocytes. It became apparent a few years later that macrophages
were also infectable by HIV. The common cellular receptor for the
virus on these cell types was CD4. A remarkable series of studies
by fIve different groups, four of which were published in the same
issue of~, showed that recombinant soluble CD4 could inhibit the
infectivity of the virus. Subsequent studies began to reveal,
however, that cells not expressing CD4 could also be infected, thus
raising the possibility that almost any cell in the body could act
as a latent reservoir for the virus. Recent observations that the
infectivity of patient isolates is not inhibited at the low
concentrations of rsCD4 that inhibit laboratory strains, also
indicate the importance of CD4-independent mechanisms. The
mechanisms of fusion of my with cellular membranes are under
investigation by a large number of laboratories. These studies
range from the determination of the oligomeric structure of the
envelope glycoproteins, to the analysis of the function of various
regions of the proteins by site-directed mutagenesis, to the
fluorimetric monitoring of membrane fusion. This book originated as
the proceedings of a Workshop on the Mechanisms and Specificity of
HIV Entry into Host Cells, held at the University of California,
San Francisco in June 1989.
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