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Therapeutic Vaccination Strategies (Paperback, Softcover reprint of the original 1st ed. 2000)
Loot Price: R1,435
Discovery Miles 14 350
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Therapeutic Vaccination Strategies (Paperback, Softcover reprint of the original 1st ed. 2000)
Series: Ernst Schering Foundation Symposium Proceedings, 30
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The induction of immune responses against tumor cells by
vaccination is rapidly evolving as a therapeutic modality with new
potentials for the treatment of cancer. It is based on the fact
that our immune system can identify tumor cells and, once
activated, is capable of developing specific immunity against the
neoplastic cells. Numerous observations and intense research
clearly document the major contribution of the immune system to the
prevention of cancer. And there are many re ports of patients
suffering from malignant melanoma or other tumors who mount a
spontaneous immune response against their tumor cells that results
in tumor regression. Based on the recent advances in our
understanding of the compo nents of our immune system, their
interactions and the regulation of immune responses, we are now
able to design vaccination strategies that induce or enhance
cell-mediated immunity against tumors. A ma jor advancement came
with the identification and characterization of relevant tumor
antigens, which are suitable target structures for anti-tu mor
immune response. First clinical trials using such vaccine
strategies have yielded encouraging results in patients. However,
in spite of many reported cases of successful therapy of cancer by
vaccination many patients still do not experience relief after such
treatments. These initial clinical trials and the accompanying
investigations have revealed a number of important results that
indicate the direction of future re search and development in the
field.
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