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Signal Transduction in Photoreceptor Cells - Proceedings of an International Workshop Held at the Research Centre Julich, Julich, Fed. Rep. of Germany, 8-11 August 1990 (Paperback)
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Signal Transduction in Photoreceptor Cells - Proceedings of an International Workshop Held at the Research Centre Julich, Julich, Fed. Rep. of Germany, 8-11 August 1990 (Paperback)
Series: Research Reports in Physics
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This volume contains manuscripts based upon talks presented at the
International Symposium on Signal Transduction in Photoreceptor
Cells which was held at the Forschungszentrum Jiilich August 8-11,
1990. * The meeting was dedicated to the memory of Hermann Kuhn who
made major contributions to our understand ing of transduction
pathways in visual cells. Presentations at the meeting were
organized around the following topics: (1) Rhodopsin Structure and
Function, (2) Transducin and Phosphodiesterase, (3) Arrestin and
Kinase, (4) The cGMP-gated 2 channel, (5) Role of Ca + in
Photoreceptors, and (6) Transduction in Inverte brates. In a
Plenary Lecture, D. Oesterhelt (Martinsried, FRG) described the sen
sory transduction system of the halobacteria. These primitive
organisms employ several retinal-containing pigments for sensory
and ion-translocation purposes. Their study is intrinsically
interesting as well as serving as potential models for the
understanding of more complex systems. Study of the structure and
function of rhodopsin has been greatly aided by use of the methods
of molecular biology. T. Sakmar (Cambridge, MA, USA) described his
use of site specific mutagenesis to make systematic substitutions
of charged residues in the transmembrane helices of rhodopsin,
leading to iden tification of the particular glutamic acid residue
that serves as a counterion for the protonated Schiff base.
Vertebrate rhodopsin has also been cloned and ex pressed in the
baculovirus system, (W. DeGrip, Nijmegen, The Netherlands) which
should facilitate production of sufficient quantities of mutant
rhodopsin to allow biophysical studies."
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