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Mathematical Models for Biological Pattern Formation (Paperback, Softcover reprint of the original 1st ed. 2001)
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Mathematical Models for Biological Pattern Formation (Paperback, Softcover reprint of the original 1st ed. 2001)
Series: Frontiers in Applications of Mathematics, 121
Expected to ship within 10 - 15 working days
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The formation of patterns in developing biological systems involves
the spatio-temporal coordination of growth, cell-cell signalling,
tissue movement, gene expression and cell differentiation. The
interactions of these complex processes are generally nonlinear,
and this mathematical modelling and analysis are needed to provide
the framework in which to compute the outcome of different
hypothesis on modes of interaction and to make experimentally
testable predictions. This collection contains papers exploring
several aspects of the hierarchy of processes occurring during
pattern formation. A number of papers address the modelling of cell
movement and deformation, with application to pattern formation
within a collection of cells in response to external signalling
cues. The results are considered in the context of pattern
generation in Dictyostelium discoideum and bacterial colonies. A
number of models at the macroscopic level explore the possible
mechanisms underlying spatio-temporal pattern generation in early
development, focussing on primitive streak, somitogenesis,
vertebrate limb development and pigmentation patterning.The latter
two applications consider in detail the effects of growth on
patterning. The potential of models to generate more complex
patterns are considered and models involving different modes of
cell-cell signalling are investigated. Pattern selection is
analyzed in the context of chemical Turing patterns, which serve as
a paradigm for morphogenesis and a model for vegetation patterns is
presented.
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