Regulation of Gastrointestinal Mucosal Growth (Paperback, 2nd Revised edition)

The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.

General

Imprint:	Morgan & Claypool Publishers
Country of origin:	United States
Series:	Colloquium Series on Integrated Systems Physiology: From Molecule to Function
Release date:	November 2016
Authors:	Rao N. Jaladanki • Jian-Ying Wang
Series editors:	D. Neil Granger • Joey P Granger
Dimensions:	235 x 191 x 8mm (L x W x T)
Format:	Paperback
Pages:	132
Edition:	2nd Revised edition
ISBN-13:	978-1-61504-734-5
Categories:	Books > Medicine > Clinical & internal medicine > Gastroenterology Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Evolution Books > Science & Mathematics > Biology, life sciences > Human biology & related topics > General Promotions
LSN:	1-61504-734-4
Barcode:	9781615047345

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!