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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Immunotoxicity, Immune Dysfunction, and Chronic Disease (Paperback, 2012 ed.)
Loot Price: R3,159
Discovery Miles 31 590
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Immunotoxicity, Immune Dysfunction, and Chronic Disease (Paperback, 2012 ed.)
Series: Molecular and Integrative Toxicology
Expected to ship within 10 - 15 working days
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Chronic diseases are the leading cause of deaths worldwide and
according to the World Economics Council and the Harvard School of
Public Health, the cost of chronic diseases is expected to reach a
staggering 48% of global gross domestic product by the year 2030.
The urgency of the issue was demonstrated in 2011 when for only the
second time in its existence, the U.N. General Assembly brought a
health issue to the floor for consideration: chronic diseases. To
date, most considerations of the issue have approached the topic
from the vantage point that chronic diseases are a myriad of
largely unconnected diseases and conditions arising in diverse
tissues, organs and physiological systems. This book,
Immunotoxicity, Immune Dysfuction, and Chronic Disease, deviates
from that prior model. It considers the interconnectivity of
chronic diseases with both environmental insult of the immune
system and subsequent immune dysfunction and inflammatory
dysregulation as the underlying basis for many, if not most,
chronic diseases. This change in the perception of
environment-immune linkages to chronic disease is significant and
has immediate implications both for the prevention of disease as
well as for the development of more effective therapeutic
approaches. Rather than considering environmental factors and types
of reported immune alterations (e.g., depressed humoral immunity)
as is common in books involving immunotoxicity, the present book
approaches the environment-immune-disease triad from the standpoint
of the disease. Each chapter emphasizes one or more specific immune
dysfunction-based chronic disease(s) or condition(s) (e.g., asthma,
atherosclerosis, multiple sclerosis, lupus) and describes: 1) the
suggested environmental risk factors, 2) the underlying immune
dysfunction(s) associated with the disease and 3) the overall
health consequences of the disease. This book is an early entry for
a new Toxicology book series for Springer titled: Molecular and
Integrative Toxicology (MaIT). The series will feature detailed
research information, but in the context of a more integrative or
holistic framework. As part of this framework, the chapters will
contain a section on "Key Points" as well as "Recommendations"
where appropriate. The goal is to cover the most timely,
state-of-the-art issues in toxicology as well as to ensure that the
information is maximally accessible for research scientists,
teachers, physicians and students. We are particularly grateful to
the numerous chapter authors for providing comprehensive and expert
disease-oriented contributions. We are also appreciative of their
willingness to consider their material not as disparate pieces of
what has become a major health crisis, but rather as key pieces in
a network of apparently interconnected health challenges.
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