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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Retroviruses - Strategies of Replication (Paperback, Softcover reprint of the original 1st ed. 1990)
Loot Price: R1,976
Discovery Miles 19 760
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Retroviruses - Strategies of Replication (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Current Topics in Microbiology and Immunology, 157
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Among the first diseases for which a viral etiology was esta-
blished were tumors, lymphomas, and sarcomas in chickens, shown by
Ellermann and Bang (1908) and Rous (1910) to be transmissible with
cell-free filtrates. The broad significance of these discoveries
was not fully recognized at first, mainly because chickens were
perceived as too distanly related to humans to provide useful and
relevant models for human disease. Change came slowly. In 1936
Bittner found that a viral agent is involved in the causation of
mammary cancer in mice, and in 1957 Gross discovered the first
murine leukemia virus. In the years following numerous
tumor-inducing viruses, infecting all classes of verte- brates,
were isolated. The decisive impulse for the development of the RNA
tumor virus field sprang from advances in cell culture. In 1958
Temin and Rubin, following initial observations of Manaker and
Groupe, worked out the conditions for virus-induced tumori- genic
transformation in cell culture and made this transform- ation the
basis for a quantitative assay of viral infectivity and
oncogenicity. The genetic and cell biological studies that grew out
of Rubin's and Temin's groundwork quickly brought into focus two
puzzling problems: a requirement for DNA synthesis early in the
lifecycle of the RNA tumor viruses, and the existence of genetic
information in the virus that is needed for oncogenesis but not for
virus reproduction.
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