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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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The Epigenetics of Autoimmunity, Volume 5 (Hardcover)
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The Epigenetics of Autoimmunity, Volume 5 (Hardcover)
Series: Translational Epigenetics
Expected to ship within 12 - 19 working days
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The Epigenetics of Autoimmunity covers a topic directly related to
translational epigenetics. Via epigenetic mechanisms, a number of
internal and external environmental risk factors, including
smoking, nutrition, viral infection and the exposure to chemicals,
could exert their influence on the pathogenesis of autoimmune
diseases. Such factors could impact the epigenetic mechanisms,
which, in turn, build relationship with the regulation of gene
expression, and eventually triggering immunologic events that
result in instability of immune system. Since epigenetic
aberrations are known to play a key role in a long list of human
diseases, the translational significance of autoimmunity
epigenetics is very high. To bridge the gap between environmental
and genetic factors, over the past few years, great progress has
been made in identifying detailed epigenetic mechanisms for
autoimmune diseases. Furthermore, with rapid advances in
technological development, high-throughput screening approaches and
other novel technologies support the systematic investigations and
facilitate the epigenetic identification. This book covers
autoimmunity epigenetics from a disease-oriented perspective and
several chapters are presented that provide advances in wide-spread
disorders or diseases such as systemic lupus erythematosus (SLE),
rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes
(T1DM), systemic sclerosis (SSc), primary Sjoegren's syndrome (pSS)
and autoimmune thyroid diseases (AITDs). These emerging epigenetic
studies provide new insights into autoimmune diseases, raising
great expectations among researchers and clinicians. This seminal
book on this topic comprehensively covers the most recent advances
in this exciting and rapidly developing new science. They might
reveal not only new clinical biomarkers for diagnosis and disease
progression, but also novel targets for potential epigenetic
therapeutic treatment.
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