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Renal Transplantation: Sense and Sensitization (Paperback, Softcover reprint of the original 1st ed. 1988)
Loot Price: R5,876
Discovery Miles 58 760
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Renal Transplantation: Sense and Sensitization (Paperback, Softcover reprint of the original 1st ed. 1988)
Series: Developments in Nephrology, 21
Expected to ship within 10 - 15 working days
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In 1986, the Committee of Experts on Blood Transfusion and
Immunohae- tology of the Council of Europe chose for their
Programme of Co-ordinated Research "An investigation of the
procurement and sharing of transplantable organs for potential
recipients who are highly sensitized to HLA-antigens." This topic
was of common concern to all centres practising renal transplan-
tion. The terms of reference of the study were: To estimate the
number of patients who are virtually "untransplantable" because of
high sensitization in each European country. To study the nature of
immunization in terms of the type and specificity of antibodies
present in the blood and techniques used for their detection. To
investigate possible practical solutions - both current and future,
invo- ing cross-matching procedures, the circulation of reference
material from patients, and the willingness of the national
organizations to share resources. 4. To explore other methods of
resolving this problem. Although the study did not offer the
prospect of a brilliant new insight into the problem of high
sensitization, it was unique in several ways: for the first time we
saw all European organizations collaborating in a common project to
provide information on their activities, their problems and the
methods to resolve them; it introduced, for this subject,
relatively novel statistical methods to investigate susceptibility
to sensitization and factors affecting transplant outcome; it
enabled a large database of transplanted highly sensitized patients
and matched controls to be assembled, that would have been
unavailable as a research resource at any single centre.
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