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Metal Compounds in Cancer Therapy (Paperback, Softcover reprint of the original 1st ed. 1994)
Loot Price: R2,783
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Metal Compounds in Cancer Therapy (Paperback, Softcover reprint of the original 1st ed. 1994)
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The discovery of the antitumour activity of cisplatin in 1965 and
its subsequent introduction into clinical trials in 1971 was the
catalyst for a major international research effort investigating
the potential of metal compounds in cancer therapy. Cisplatin now
occupies an important place in the armamentarium of the oncologist
due to its effectiveness in the treatment of testicular cancer. A
second generation analogue, carbo platin, offers reduced toxicity
together with therapeutic activity, which gives it a place in the
front-line therapy of genitourinary cancers. These and other
successes have encouraged the search for novel metal-based drugs
for cancer therapy. Research has shown that metal compounds have
potential for activity not only as cytotoxic antitumour agents, but
also in areas such as adjuvant therapy, diagnosis and
immunotherapy. The aim of this book is to review and describe the
major achievements and developments arising from this international
research effort. The contributing authors come from labora tories
throughout Europe and America and represent the many disci plines
characteristic of this research, such as clinical research,
pharmacology, tumour biology and inorganic medicinal chemistry."
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