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Alphaherpesviruses - Molecular Virology (Hardcover, New)
Loot Price: R5,631
Discovery Miles 56 310
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Alphaherpesviruses - Molecular Virology (Hardcover, New)
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Alphaherpesviruses are a fascinating group of DNA viruses that
include important human pathogens, such as herpes simplex virus
type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV) - the
causative agents of cold sores, genital ulcerous disease, and
chickenpox/shingles, respectively. A key attribute of these viruses
is their ability to establish lifelong latent infection in the
peripheral nervous system of the host. Such persistence requires
subversion of the host's immune system and intrinsic antiviral
defense mechanisms. Understanding the mechanisms of the immune
evasion and what triggers viral reactivation is a major challenge
for today's researchers. This has prompted enormous research
efforts into understanding the molecular and cellular biology of
these viruses. This up-to-date and comprehensive study distills the
most important research in this area, providing a timely overview
of the field. Topics include: transcriptional regulation, DNA
replication, translational control, virus entry and capsid
assembly, the role of microRNAs in infection, and oncolytic vectors
for cancer therapy. In addition, there is coverage of virus-host
interactions, including apoptosis, subversion of host protein
quality control and DNA damage response pathways, autophagy,
establishment and reactivation from latency, interferon responses,
immunity, and vaccine development. This is essential reading for
everyone working with alphaherpesviruses and will be of interest to
all virologists working on latent infections.
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