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Books > Medicine > General issues > Public health & preventive medicine > Epidemiology & medical statistics
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Sample Size Calculations in Clinical Research (Hardcover, 3rd edition)
Loot Price: R4,038
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Sample Size Calculations in Clinical Research (Hardcover, 3rd edition)
Series: Chapman & Hall/CRC Biostatistics Series
Expected to ship within 9 - 15 working days
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Praise for the Second Edition: "... this is a useful, comprehensive
compendium of almost every possible sample size formula. The strong
organization and carefully defined formulae will aid any researcher
designing a study." -Biometrics "This impressive book contains
formulae for computing sample size in a wide range of settings.
One-sample studies and two-sample comparisons for quantitative,
binary, and time-to-event outcomes are covered comprehensively,
with separate sample size formulae for testing equality,
non-inferiority, and equivalence. Many less familiar topics are
also covered ..." - Journal of the Royal Statistical Society Sample
Size Calculations in Clinical Research, Third Edition presents
statistical procedures for performing sample size calculations
during various phases of clinical research and development. A
comprehensive and unified presentation of statistical concepts and
practical applications, this book includes a well-balanced summary
of current and emerging clinical issues, regulatory requirements,
and recently developed statistical methodologies for sample size
calculation. Features: Compares the relative merits and
disadvantages of statistical methods for sample size calculations
Explains how the formulae and procedures for sample size
calculations can be used in a variety of clinical research and
development stages Presents real-world examples from several
therapeutic areas, including cardiovascular medicine, the central
nervous system, anti-infective medicine, oncology, and women's
health Provides sample size calculations for dose response studies,
microarray studies, and Bayesian approaches This new edition is
updated throughout, includes many new sections, and five new
chapters on emerging topics: two stage seamless adaptive designs,
cluster randomized trial design, zero-inflated Poisson
distribution, clinical trials with extremely low incidence rates,
and clinical trial simulation.
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