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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Opioids - Pharmacology, Abuse, and Addiction (Hardcover, 1st ed. 2022)
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Opioids - Pharmacology, Abuse, and Addiction (Hardcover, 1st ed. 2022)
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Opioids are responsible for the vast majority of preventable deaths
related to drug use, and opioid crisis is a serious international
health problem. Opioids are also the mainstay in pain treatment and
are invaluable tools in palliative care. The purpose of this book
is to present an overview of the complex field of opioid
pharmacology through evidence-based chapters in clear language
backed up with sound scientific evidence, providing researchers and
health professionals with a firm understanding of their effects and
mechanisms of action. The authors present an overview of the
history of opioids from ancient civilizations to the current opioid
crisis, covering state-of-the-art advances on opioid-induced signal
transduction, opioids in pain management, and the neuroinflammatory
effects of opioids. Also discussed are opioid use disorders and
their treatment. The authors also review the growing body of
evidence of opioid effects on innate and adaptive immune responses,
discussing the molecules involved in the crosstalk between opioids
and innate immunity receptors to provide an updated view of those
compounds as important regulators of inflammation and host defense
against pathogens and damage. The overall purpose is to provide the
reader with a deeper knowledge of this field despite the
complexities associated with the existence of numerous ligands,
receptor subtypes, and complex pharmacological profiles. To this
end, the chapter authors are specialists in the field who also have
extensive experience in teaching, hoping to lend their expertise in
translating complex concepts into comprehensive and clear
explanations.
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