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Neuropathogenic Viruses and Immunity (Paperback, Softcover reprint of the original 1st ed. 1992)
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Neuropathogenic Viruses and Immunity (Paperback, Softcover reprint of the original 1st ed. 1992)
Series: Infectious Agents and Pathogenesis
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There has been a tremendous increase in interest in the
neuropathogenicity of viruses during the past decade as we have
come to recognize that the human immunodeficiency virus, which
causes the acquired immunodeficiency syndrome (AIDS), can infect
glial cells and cause neurological disease. Yet this increase has
not been limited to AIDS but has extended to viruses that infect
either or both the central and peripheral nervous systems. The
changes examined here include both neurological and psychological
diseases or syndromes. Moreover, the chapters in this volume review
the interaction of the host immune system with the viruses examined
and how such interactions may increase or decrease the neuropatho
genicity of the viruses. Questions regarding viral
neuropathogenesis include: (I) What is the mode of transmission of
virus to the nervous system? (2) What types of cells are infected,
and do they contain receptors for the virus? (3) What is the extent
of damage that results from viral infection? (4) What are the
immunologic mecha nisms by which damage is mediated or limited?
Many of these questions remain unanswered, but this volume delves
into efforts to provide some answers.
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