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Virus-Induced Immunosuppression (Paperback, Softcover reprint of the original 1st ed. 1989)
Loot Price: R1,594
Discovery Miles 15 940
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Virus-Induced Immunosuppression (Paperback, Softcover reprint of the original 1st ed. 1989)
Series: Infectious Agents and Pathogenesis
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It is now widely acknowledged that at the beginning of this century
Claude von Pirquet first pointed out that a viral disease, i. e.,
measles, resulted in an anergy or depression of preexisting immune
response, namely, delayed continuous hypersensitivity to PPD
derived from Mycobacterium tuberculosis. Thereafter ob servations
that viral infections may result in immunosuppression have been
recorded by many clinicians and infectious disease investigators
for six or seven decades. Nevertheless, despite sporadic reports
that infectious diseases caused by viruses may result in either
transient or prolonged immunodepression, investigation of this
phenomenon languished until the mid-1960s, when it was pointed out
that a number of experimental retroviral infections of mice with
tumor viruses may result in marked immunosuppression. However, it
was not until the recognition of the new epidemic of acquired
immunodeficiency syn drome (AIDS) caused by the human
immunodeficiency virus and related vi ruses that acquired
immunodeficiencies associated with virus infection became general
knowledge among biomedical investigators as well as the lay public.
A number of reviews published during the past decade or so pointed
out that numerous viruses may affect humoral and cellular immune
responses. Furthermore, expanding knowledge about the nature and
mechanisms of both humoral and cellular immunity and pathogenesis
of viral infections has pro vided clinical and experimental models
for investigating in depth how and why viruses of man and animals
profoundly affect immune responses."
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