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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II) - Thiol "Switch-on" Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents (Hardcover, 1st ed. 2016)
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Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II) - Thiol "Switch-on" Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents (Hardcover, 1st ed. 2016)
Series: Springer Theses
Expected to ship within 12 - 17 working days
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This thesis focuses on the development of gold- and non-classical
platinum-based anti-cancer agents that display distinctively
different anti-cancer mechanisms compared to the commonly used
cisplatin. These metal complexes contain N-heterocyclic carbene
(NHC) ligands which are able to form strong M-C(NHC) bonds,
conferring high stability and favorable lipophilicity, reactivity
and binding specificity of metal complexes on biomolecules. The
author demonstrates significant advances made in anti-cancer
gold(III), gold(I) and platinum(II) complexes. Detailed chemical
synthesis, in vitro and/or in vivo anti-cancer activities are
clearly presented including: (i) a class of Au(III) complexes
containing a highly fluorescent N^N^N ligand and NHC ligand that
simultaneously act as fluorescent thiol "switch-on" probes and
anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed
diphosphine and bis(NHC) ligand displaying favorable stability and
showing significant inhibition of tumor growth in two independent
mice models with no observable side effects; and (iii) a panel of
stable luminescent cyclometalated platinum(II) complexes exhibiting
high specificity to localize to the endoplasmic reticulum (ER)
domain, inducing ER stress and cell apoptosis. These works
highlight the clinical potential that gold and platinum complexes
offer for cancer treatment.
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