The thymus is an evolutionarily ancient primary lymphoid organ
common to all vertebrates in which T cell development takes place.
Failing thymus function is associated with immunodeficiency and/or
autoimmunity. In this volume, leading experts provide a
comprehensive overview of recent advances in thymopoiesis research.
The chapters cover the development of the thymic epithelial
microenvironment, address the formation of a diverse and
self-tolerant repertoire of T cell receptors as the basis for
cellular immunity, discuss the mechanisms by which progenitor cells
colonize the thymus and detail the molecular basis for T lineage
decisions. The reviews illustrate the important role of the
multifaceted process of thymopoiesis for adaptive immunity.
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