A very early step in microbial colonization and pathogenesis is
that involving recog nition of the host by the microbe. In the
final analysis such recognition is due to interaction between
specific molecules on the two sides, without which host and microbe
would ignore each other. It is therefore exciting to learn the
rules that govern host-microbe interaction at to a large extent
determines whether or not we are infected by the molecular level,
which influenza virus, leishmanias, staphylococci and other
pathogens. This book is a compendium of the addresses delivered at
a symposium on molecular interaction at Porvoo, Finland in August
1991. Realizing that there are no a priori differ ences in receptor
recognition in viruses, eukaryotic parasites and bacteria, we
freely inter mingled these microbes at the symposium, and in this
book. We found the interdisciplinary discussions and comparisons
both educative and stimulating. Thus the book is divided into parts
that focus on host cell receptors, on microbial recognition
molecules and molecules that mediate microbial interaction with a
host cell receptor and, briefly, on the molecular events that
follow. Although many microbes and many cellular receptors are
missing from the book -owing to the limited duration and size of
the symposium -the articles presented here constitute an impressive
body of examples of how initial host-microbe interaction can come
about. We believe that as such the book is a useful and interesting
overview of the mechanisms and principles involved in these
interactions.
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