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Radiation Myelopathy (Hardcover, 1st ed. 2022)
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Radiation Myelopathy (Hardcover, 1st ed. 2022)
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This book covers every aspect of radiation myelopathy and considers
the evidence from all species in which it has been studied. The
historical and current understanding of the pathogenesis of this
rare but devastating injury is first discussed. The evidence
regarding the role of a variety of factors in radiation myelopathy
is then reviewed. Readers will find detailed information on the
impacts of total radiation dose, radiation volume, dose
fractionation, hyper fractionation, age, anatomic level,
comorbidities, radiation modifiers, other therapies, and
retreatment of the spinal cord. Given the similarity of the
pathogenesis of radiation myelopathy in humans and experimental
animals, the potential for cross-species modelling of dose response
is explored, with attention to relevant species differences.
Treatment of the condition is also fully considered. New theories
are presented regarding retreatment, small volume response, and the
final step in white matter necrosis. The final chapter addresses
the medicolegal issues elicited by radiation myelopathy, which is
often the result of treatment error. Radiation Myelopathy will be
of high value for radiation oncologists, radiation physicists,
dosimetrists, biologists, neurologists, medical oncologists, and
attorneys.
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