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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
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Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control - Insights for Drug Discovery (Paperback, Softcover reprint of the original 1st ed. 2001)
Loot Price: R4,475
Discovery Miles 44 750
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Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control - Insights for Drug Discovery (Paperback, Softcover reprint of the original 1st ed. 2001)
Expected to ship within 10 - 15 working days
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The localized attachment of circulating leukocytes to endothelium
has been recognized as the cellular hallmark of the inflammatory
response. This adhesive interaction, a necessary antecedent to the
emigration of leukocytes from the blood into the tissues, is
mediated by vascular adhesion molecules. Leukocyte Recruitment,
Endothelial Cell Adhesion Molecules and Transcriptional Control:
Insights for Drug Discovery outlines some of the cellular and
molecular mechanisms of inflammation with contributions from top
researchers. This volume provides an overview of three of these
endothelial adhesion molecules, as examples of key mediators of
leukocyte recruitment. It reviews the structure and regulation of
these cell surface proteins and focus on the rapidly expanding
field of transcriptional regulation of these inducible proteins,
and closes with a discussion of drug discovery possibilities that
target the regulation of leukocyte recruitment. This book will be
of interest for any researchers, in academia or industry, looking
for an overview of leukocyte recruitment or novel approaches to
drug discovery.
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