This book gives physical chemists a broader view of potential
biological applications of their techniques for the study of
nucleic acids in the gas phase. It provides organic chemists,
biophysicists, and pharmacologists with an introduction to new
techniques they can use to find the answers to yet unsolved
questions. Laboratory sciences have bloomed with a variety of
techniques to decipher the properties of the molecules of life.
This volume introduces techniques used to investigate the
properties of nucleic acids in the absence of solvent. It
highlights the specificities pertaining to the studies of nucleic
acids, although some of the techniques can similarly be applied to
the study of other biomolecules, like proteins. The first part of
the book introduces the techniques, from the transfer of nucleic
acids to the gas-phase, to their detailed physico-chemical
investigation. Each chapter is devoted to a specific molecular
property, and illustrates how various approaches (experimental and
theoretical) can be combined for the interpretation.
The second part of the book is devoted to applying the gas-phase
approaches to solve specific questions related to the biophysics,
biochemistry or pharmacology of nucleic acids.
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