TDP-43 and Neurodegeneration - From Bench to Bedside (Paperback)

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43's structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders.

General

Imprint:	Academic Press Inc
Country of origin:	United States
Release date:	October 2021
First published:	2021
Editors:	Vijay Kumar • Manoj Kumar Jaiswal
Dimensions:	229 x 152 x 18mm (L x W x T)
Format:	Paperback
Pages:	270
ISBN-13:	978-0-12-820066-7
Categories:	Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
LSN:	0-12-820066-9
Barcode:	9780128200667

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