Contrast Agents I - Magnetic Resonance Imaging (Hardcover, 2002 ed.)

Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1-2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Topics in Current Chemistry, 221
Release date:	2002
First published:	2002
Editors:	Werner Krause
Dimensions:	235 x 155 x 20mm (L x W x T)
Format:	Hardcover
Pages:	249
Edition:	2002 ed.
ISBN-13:	978-3-540-42247-1
Categories:	Books > Medicine > Other branches of medicine > Medical imaging > Nuclear magnetic resonance (NMR / MRI) Books > Science & Mathematics > Chemistry > Organic chemistry > General Books > Science & Mathematics > Chemistry > Physical chemistry > General Books > Science & Mathematics > Chemistry > Analytical chemistry > Qualitative analytical chemistry > Magnetic resonance
LSN:	3-540-42247-1
Barcode:	9783540422471

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