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Books > Science & Mathematics > Chemistry > Analytical chemistry > Qualitative analytical chemistry > Magnetic resonance
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Contrast Agents I - Magnetic Resonance Imaging (Hardcover, 2002 ed.)
Loot Price: R7,663
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Contrast Agents I - Magnetic Resonance Imaging (Hardcover, 2002 ed.)
Series: Topics in Current Chemistry, 221
Expected to ship within 18 - 22 working days
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Extracellular MRI and X-ray contrast agents are characterized by
their phar- cokinetic behaviour.After intravascular injection their
plasma-level time curve is characeterized by two phases. The agents
are rapidly distributed between plasma and interstitial spaces
followed by renal elimination with a terminal half-live of
approximatly 1-2 hours. They are excreted via the kidneys in
unchanged form by glomerular filtration. Extracellular
water-soluble contrast agents to be applied for X-ray imaging were
introduced into clinical practice in 1923. Since that time they
have proved to be most valuable tools in diagnostics.They contain
iodine as the element of choice with a sufficiently high atomic
weight difference to organic tissue. As positive contrast agents
their attenuation of radiation is higher compared with the
attenuation of the surrounding tissue. By this contrast enhancement
X-ray diagnostics could be improved dramatically. In
2,4,6-triiodobenzoic acid derivatives iodine is firmly bound.
Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid
like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral)
X-ray contrast agents in most cases [1].
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