Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology (Paperback, 1st ed. 2016)

This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	SpringerBriefs in Immunology
Release date:	September 2016
First published:	2016
Authors:	Witold Lasek • Radoslaw Zagozdzon
Contributors:	Marek Jakobisiak
Dimensions:	235 x 155 x 4mm (L x W x T)
Format:	Paperback
Pages:	75
Edition:	1st ed. 2016
ISBN-13:	978-3-319-46905-8
Categories:	Books > Science & Mathematics > Biology, life sciences > Cellular biology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	3-319-46905-3
Barcode:	9783319469058

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