Skin Langerhans (Dendritic) Cells in Virus Infections and AIDS (Paperback, Softcover reprint of the original 1st ed. 1991)

Over the generations the skin has been the site for immunization against smallpox. This method of immunization was described in a letter written by Lady Mary Montagu on April 1, 1717 in Adrianopole, Turkey: "The small-pox, so fatal, and so general amongst us, is here entirely harmless by the invention of ingrafting, which is the term they give it. . . The old woman comes with a nut-shell full of the matter of the best sort of small-pox . . . She immediately rips open (the skin) with a large needle . . . and puts into the vein as much venom as can lie upon the head of her needle, and after binds up the wound. There is no example of anyone that died of it; and you may believe that I am satisfied of the safety of this experiment since I intend to try it on my dear little son" (Letters from the right Honourable Lady Mary Montagu 1709-1762. Published by J. M. Dent and Co. London, 2nd edition, September, 1906, p. 124. ) The "variolation" method was, 80 years later, markedly improved by the use of cowpox virus, as reported by Edward Jenner in 1796. The successful method of intradermal immunization against smallpox and later against other virus diseases is in fact based on the presence of anitigen-presenting dendritic cells in the skin.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Developments in Medical Virology, 7
Release date:	October 2012
First published:	1991
Editors:	Yechiel Becker
Dimensions:	235 x 155 x 18mm (L x W x T)
Format:	Paperback
Pages:	320
Edition:	Softcover reprint of the original 1st ed. 1991
ISBN-13:	978-1-4613-6759-8
Categories:	Books > Medicine > Clinical & internal medicine > Dermatology Books > Medicine > Other branches of medicine > Pathology > Medical microbiology & virology Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	1-4613-6759-X
Barcode:	9781461367598

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