Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to offer unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we begin our lives, how we develop and grow, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is an essential component of the inevitable transition towards personalized health and medicine. As the medical establishment begins to explore and evaluate the role of personal genomics in health and medicine, both clinicians and patients alike will gain from becoming well versed in both the power and the pitfalls of personal genomic information. Furthermore, it is likely that all students of the biomedical sciences will soon be required to gain crucial understanding in the emerging field of personal genomics. Exploring Personal Genomics provides a novel, inquiry-based approach to the understanding and interpretation of the practical, medical, physiological, and societal aspects of personal genomic information. The material is presented in two parts: the first provides readers of all backgrounds with a fundamental understanding of the biology of human genomes, information on how to obtain and understand digital representations of personal genomic data, tools and techniques for exploring the personal genomics of ancestry and genealogy, discovery and interpretation of genetic trait associations, and the role of personal genomics in drug response. The second part offers more advanced readers an understanding of the science, tools, and techniques for investigating interactions between a personal genome and the environment, connecting DNA to physiology, and assessing rare variants and structural variation. This book aims to support undergraduate and graduate studies in medicine, genetics, molecular biology, and bioinformatics. Additionally, the design of the content is such that medical practitioners, professionals working in the biomedical sciences or related fields, and motivated lay individuals interested in exploring their personal genetic data should find it relevant and approachable.

Although the problem of controlling the spread of exotic invasive plant and animal species in the United States has been recognized for quite some time, it has been lacking an adequate legislative mandate, public awareness, and sufficient funding to meet the challenge. This ACS Symposium Series title showcases the many diverse efforts being made to control invasive species at the federal, state, and local levels. It recognizes the global extent of the problem and compares the methods used in other countries with those of the U.S., and includes recommendations of how best to proceed from here.

Observing Bioethics examines the history of bioethics as a discipline related not only to modern biology, medicine, and biotechnology, but also to the core values and beliefs of American society and its courts, legislatures, and media. The book is written from the perspective of two social scientists--a sociologist of medicine(Renee C. Fox) and a historian of medicine (Judith P. Swazey)--who have participated in bioethics since the emergence of this multidisciplinary field more than 30 years ago.
Fox and Swazey draw on first-hand observations and experiences in a variety of American bioethical settings; face-to-face interviews with first- and second-generation figures in the genesis and early unfolding of bioethics; a detailed examination of the theatrical media coverage of what was considered to be a banner event in the annals of bioethics (the creation and birth of the cloned sheep, Dolly); case studies of how bioethics has internationally developed; and a large corpus of primary documents and secondary source materials.
While recognizing the intellectual, moral, and sociological importance of American bioethics, Fox and Swazey are critical of its characteristics. Foremost among these are what they identify as the problems of thinking socially, culturally, and internationally in American bioethics; the 'tenuous interdisciplinarity' of the field; and the troubling extent to which the 'culture wars' have penetrated bioethics.
This book will appeal to a wide range of doctors, scientists, and academics who are involved in the history and sociology of bioethics.

Why are rates of conditions like autism, asthma, obesity and allergies exploding at an unprecedented pace? Why are humans living longer, getting smarter and having far fewer children? If Darwin were alive today, how would he explain this new world? Could our children eventually become a different species - or several? In Evolving Ourselves, futurist Juan Enriquez and scientist Steve Gullans take us on a sweeping tour of how humans are changing the course of evolution - sometimes intentionally, sometimes not. It is a chronicle of where our remarkable new capabilities for altering our bodies, other living creatures, and our environment are taking us in the near term, and introduces the possibility that we might cause our own extinction in the long run.

In recent decades there has been an explosion in work in the social and physical sciences describing the similarities between human and nonhuman as well as human and non-animal thinking. This work has explicitly decentered the brain as the sole, self-contained space of thought, and it has found thinking to be an activity that operates not only across bodies but also across bodily or cellular membranes, as well as multifaceted organic and inorganic environments. For example, researchers have looked at the replication and spread of slime molds (playfully asking what would happen if they colonized the earth) to suggest that they exhibit 'smart behavior' in the way they move as a potential way of considering the spread of disease across the globe. Other scholars have applied this model of non-human thought to the reach of data mining and global surveillance. In The Biopolitics of Alphabets and Embryos, Ruth Miller argues that these types of phenomena are also useful models for thinking about the growth, reproduction, and spread of political thought and democratic processes. Giving slime, data and unbounded entities their political dues, Miller stresses their thinking power and political significance and thus challenges the anthropocentrism of mainstream democratic theories. Miller emphasizes the non-human as highly organized, systemic and productive of democratic growth and replication. She examines developments such as global surveillance, embryonic stem cell research, and cloning, which have been characterized as threats to the privacy, dignity, and integrity of the rational, maximizing and freedom-loving democratic citizen. By shifting her level of analysis from the politics of self-determining subjects to the realm of material environments and information systems, Miller asks what might happen if these alternative, nonhuman thought processes become the normative thought processes of democratic engagement.

Written for all therapists who want to understand this groundbreaking theory as it might actually show up in their day-to-day practice, this book offers a comprehensive approach to polyvagal-informed intervention. Worksheets and experiential exercises designed to map and shape autonomic response provide therapists with a road map for bringing polyvagal theory into their clinical practice.

For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, measured by major advances, the greatest decade in the history of brain studies was mid-twentieth century, especially the 1950s. The first to focus on worldwide contributions in this period, the book ranges through dozens of astonishing discoveries at all levels of the brain, from DNA (Watson and Crick), through growth factors (Hamburger and Levi-Montalcini), excitability (Hodgkin and Huxley), synapses (Katz and Eccles), dopamine and Parkinson's (Carlsson), visual processing (Hartline and Kuffler), the cortical column (Mountcastle), reticular activating system (Morruzzi and Magoun) and REM sleep (Aserinsky), to stress (Selye), learning (Hebb) and memory (HM and Milner). The clinical fields are also covered, from Cushing and Penfield, psychosurgery and brain energy metabolism (Kety), to most of the major psychoactive drugs in use today (beginning with Delay and Deniker), and much more.
The material has been the basis for a highly successful advanced undergraduate and graduate course at Yale, with the classic papers organized and accessible on the web. There is interest for a wide range of readers, academic, and lay because there is a focus on the creative process itself, on understanding how the combination of unique personalities, innovative hypotheses, and new methods led to the advances. Insight is given into this process through describing the struggles between male and female, student and mentor, academic and private sector, and the roles of chance and persistence. The book thus provides a new multidisciplinary understanding of the revolution that created the modern field of neuroscience and set the bar for judging current and future advances.

The History of British Birds reviews our knowledge of avifaunal history over the last 15,000 years, setting it in its wider historical and European context. The authors, one an ornithologist, the other an archaeologist, integrate a wealth of archaeological data to illuminate and enliven the story, indicating the extent to which climatic, agricultural, and social changes have affected the avifauna. They discuss its present balance, as well as predicting possible future changes.
It is a popular misconception that bird bones are rarely preserved (compared with mammals), and cannot be reliably identified when they are found. The book explores both these contentions, armed with a database of 9,000 records of birds that have been identified on archaeolgical sites. Most are in England, but sites elsewhere in Great Britian, Ireland, the Isle of Man and the Channel Isles are included.
Britain's most numerous bird is also the most widespread in the archaeological record, but some of the more charismatic species also have a rich historical pedigree. For example, we can say quite a lot about the history of the Crane, Red Kite, White-tailed Eagle and great Auk. The history of many introduced domestic species can also be illuminated. Even so, there remain uncertainties, posed by difficulties of dating or identification, the vagaries of the archaeological record or the ecological specialities of the birds themselves. These issues are highlighted, thus posing research questions for others to answer.
And the commonest British bird, then and now? Buy the book and read on...

The family of palms (Palmae or Arecaceae) is of major economic importance, both on a large industrial scale and in peasant agriculture. The palms offer a unique challenge to botanists because of their frequently gigantic size and unusual mechanical properties; they are of interest to evolutionists who wish to know how such an unusual plant form could have evolved and to ecologists who wish to learn about the distinct adaptive features of palms. In this book each organ of the plant and each successive phase in its life-cycle is examined, beginning with seed germination and gradually moving through the vegetative cycle to the production of inflorescence, flower, fruit, and seed, giving a general picture of how the palm 'works'. The information is presented in systematic form. Much of the recent extensive literature on palm biology is summarized and the relationship of the palms to other flowering plants is discussed. This book will be of value both to academic botanists and agronomists.

This Handbook examines disparities in public health by highlighting recent theoretical and methodological advances in cultural neuroscience. It traces the interactions of cultural, biological, and environmental factors that create adverse physical and mental health conditions among populations, and investigates how the policies of cultural and governmental institutions influence such outcomes. In addition to providing an overview of the current research, chapters demonstrate how a cultural neuroscience approach to the study of the mind, brain, and behavior can help stabilize the quality of health of societies at large. The volume will appeal especially to graduate students and professional scholars working in psychology and population genetics. The Oxford Handbook of Cultural Neuroscience represents the first collection of scholarly contributions from the International Cultural Neuroscience Consortium (ICNC), an interdisciplinary group of scholars from epidemiology, anthropology, psychology, neuroscience, genetics, and psychiatry dedicated to advancing an understanding of culture and health using theory and methods from cultural neuroscience. The Handbook is intended to introduce future generations of scholars to foundations in cultural neuroscience, and to equip them to address the grand challenges in global mental health in the twenty-first century.

A beautifully illustrated pocket-size hardcover guide to the mushrooms of North America--a must-have for any mushroom enthusiast's backpack or home library. Mushrooms: An Illustrated Field Guide is a compact, beautifully illustrated field guide to 50 North America's most popular mushrooms. Inside this elegant hardcover, you'll find profiles on individual species, each showcasing a full-page illustration, plus a definition of fungi, information on where to find mushrooms and how--and when--to collect them, and, last but not least, notes on how to avoid mushroom poisoning. Discover the wonderful world of North American mushrooms, including: - Chanterelles (Cantharellus) - Fly Agaric (Amanita muscaria) - Hen of the Woods (Grifola frondose) - Morels (Morchellaceae) - Puffballs (Calvatia) - Stinkhorn Mushrooms (Phallaceae) And many, many more! Visually stunning, Mushrooms: An Illustrated Field Guide is an engrossing overview of North America's remarkable and diverse mushrooms. You'll find opportunities for discovery on every page.

The Arctic Tundra and adjacent Boreal Forest or Taiga support the most cold-adapted flora and fauna on Earth. The evolutionary capacity of both plants and animals to adapt to these thermally limiting conditions has always attracted biological investigation and is a central theme of this book. How the polar biota will adapt to a warmer world is creating significant and renewed interest in this habitat. The Arctic has always been subject to climatic fluctuation and the polar biota has successfully adapted to these changes throughout its evolutionary history. Whether or not climatic warming will allow the Boreal Forest to advance onto the treeless Tundra is one of the most tantalizing questions that can be asked today in relation to terrestrial polar biology. Tundra-Taiga Biology provides a circum-polar perspective of adaptation to low temperatures and short growing seasons, together with a history of climatic variation as it has affected the evolution of terrestrial life in the Tundra and the adjacent forested Taiga. It will appeal to researchers new to the field and to the many students, professional ecologists and conservation practitioners requiring a concise but authoritative overview of the biome. Its accessibility also makes it suitable for undergraduate and graduate students taking courses in tundra, taiga, and arctic ecology.

The third edition of The Basics of Bioethics continues to provide a balanced and systematic ethical framework to help students analyze a wide range of controversial topics in medicine, and consider ethical systems from various religious and secular traditions. The Basics of Bioethics covers the "Principalist" approach and identifies principles that are believed to make behavior morally right or wrong. It showcases alternative ethical approaches to health care decision making by presenting Hippocratic ethics as only one among many alternative ethical approaches to health care decision-making. The Basics of Bioethics offers case studies, diagrams, and other learning aids for an accessible presentation. Plus, it contains an all-encompassing ethics chart that shows the major questions in ethics and all of the major answers to these questions.

Migration, broadly defined as directional movement to take advantage of spatially distributed resources, is a dramatic behaviour and an important component of many life histories that can contribute to the fundamental structuring of ecosystems. In recent years, our understanding of migration has advanced radically with respect to both new data and conceptual understanding. It is now almost twenty years since publication of the first edition, and an authoritative and up-to-date sequel that provides a taxonomically comprehensive overview of the latest research is therefore timely. The emphasis throughout this advanced textbook is on the definition and description of migratory behaviour, its ecological outcomes for individuals, populations, and communities, and how these outcomes lead to natural selection acting on the behaviour to cause its evolution. It takes a truly integrative approach, showing how comparisons across a diversity of organisms and biological disciplines can illuminate migratory life cycles, their evolution, and the relation of migration to other movements. Migration: The Biology of Life on the Move focuses on migration as a behavioural phenomenon with important ecological consequences for organisms as diverse as aphids, butterflies, birds and whales. It is suitable for senior undergraduate and graduate level students taking courses in behaviour, spatial ecology, 'movement ecology', and conservation. It will also be of interest and use to a broader audience of professional ecologists and behaviourists seeking an authoritative overview of this rapidly expanding field.

Because of their vital role in the emergence of humanity, tools and their uses have been the focus of considerable worldwide study. This volume brings together international research on the use of tools among primates and both prehistoric and modern humans. The book represents leading work being done by specialists in anatomy, neurobiology, prehistory, ethnology, and primatology. Whether composed of stone, wood, or metal, tools are a prolongation of the arm that acquire precision through direction by the brain. The same movement, for example, may have been practiced by apes and humans, but the resulting action varies according to the extended use of the tool. It is therefore necessary, as the contributors here make clear, to understand the origin of tools, and also to describe the techniques involved in their manipulation, and the possible uses of unknown implements. Comparison of the techniques of chimpanzees with those of prehistoric and modern peoples has made it possible to appreciate the common aspects and to identify the differences. The transmission of ability has also been studied in the various relevant societies: chimpanzees in their natural habitat and in captivity, hunter-gatherers, and workmen in prehistoric and in modern times. In drawing together much valuable research, this work will be an important and timely resource for social and behavioral psychologists, anthropologists, paleontologists, and animal behaviorists.

This manual provides an easy guide to pain management for the veterinary practitioner. Beginning with pain terminology, it goes on to describe to physiology of pain, management strategies, various drugs and techniques, and the management of specific conditions and procedures. Strategies for the treatment of pain are comprehensively reviewed, with an overview of the mechanisms by which pain is perceived and the principles of pain management. The drugs currently used in the treatment of acute and chronic pain are discussed as well as the specific techniques that can be used to control intra- and post operative pain in dogs and cats. The book covers a broad range of information on specific aspects of pain management from analgesic techniques to management of chronic pain to pain perception. Published by Teton New Media USA and distributed by CRC Press outside of North America.

The Shape of Thought: How Mental Adaptations Evolve presents a road map for an evolutionary psychology of the twenty-first century. It brings together theory from biology and cognitive science to show how the brain can be composed of specialized adaptations, and yet also an organ of plasticity. Although mental adaptations have typically been seen as monolithic, hard-wired components frozen in the evolutionary past, The Shape of Thought presents a new view of mental adaptations as diverse and variable, with distinct functions and evolutionary histories that shape how they develop, what information they use, and what they do with that information. The book describes how advances in evolutionary developmental biology can be applied to the brain by focusing on the design of the developmental systems that build it. Crucially, developmental systems can be plastic, designed by the process of natural selection to build adaptive phenotypes using the rich information available in our social and physical environments. This approach bridges the long-standing divide between "nativist" approaches to development, based on innateness, and "empiricist" approaches, based on learning. It shows how a view of humans as a flexible, culturally-dependent species is compatible with a complexly specialized brain, and how the nature of our flexibility can be better understood by confronting the evolved design of the organ on which that flexibility depends.

The role of parasites and pathogens in the evolution of life history traits is of increasing interest to both ecologists and evolutionary biologists. Immunology, which was once studied almost exclusively by immunologists, has become an important area of proximate investigation to animal physiologists as a means for understanding changes in disease susceptibility and the neural and neuroendocrine mechanisms that mediate these changes. The coalescence of these different perspectives has given rise to the field of ecological immunology, an interdisciplinary research field that examines interactions among host physiology and disease ecology in a wide range of environmentally relevant contexts. The goal of ecological immunology is to understand immune function in the context of life-history traits across a wide range of organisms. Research within the field combines diverse approaches from a wide range of scientific disciplines including evolution, ecology, and life history theory to endocrinology, neuroscience, molecular biology, and behavior. This book critically reviews recent advances in the discipline of ecoimmunology. Chapters are written by experts in their respective fields and cover diverse topics including how environmental factors can affect host immune function, the complex dynamics among host immunity, pathogen prevalence and disease susceptibility, and the physiological mechanisms that lead to adaptive changes in immune responses. By integrating analyses of immune system function within animal biology, investigators will gain will gain a more comprehensive and satisfying understanding of organism-environment interactions at both ultimate and proximate levels of analysis.

The science of autism has seen tremendous breakthroughs in the past few decades. A multitude of relatively rare mutations have been identified to explain around 15 % of autism cases with many of these genetic causes systematically examined in animal models. This marriage of human genetics and basic neurobiology has led to major advances in our understanding of how these genetic mutations alter brain function and help to better understand the human disease. These scientific approaches are leading to the identification of potential therapeutic targets for autism that can be tested in the very same genetic models and hopefully translated into novel, rational therapies. The Autisms: Molecules to Model Systems provides a roadmap to many of these genetic causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, the book explains, is the key to understanding the pathophysiology of autism and ultimately to identifying novel treatments.

Flora of North America, Volume 3, provides information on many of the most familiar wildflowers and trees in North America. Included are treatments of the buttercup family (Ranunculacaeae), with such plants as delphiniums and columbines, and the poppy family (Papveraceae). Most of the important broadleaf tree species are covered, including the oaks (Fagaceae), elms (Ulmaceae), birches (Betulaceae), walnuts (Juglandaceae), plane trees (Plantanaceae), and magnolias (Magnoliaceae). Many striking families are covered, such as the dutchman's pipe family (Aristochiaceae), and the aquatic families Nymphaeceae (water lilies), and Melumbonaceae (lotus).

Identification keys, summaries of habitats and geographic ranges, distribution maps, pertinent synonymies, descriptions, chromosome numbers, phenological information, and other significant biological observations are given for each species. The treatments, written and reviewed by experts throughout the systematic botanical community, are based on original observations of herbarium specimens, and wherever possible, on living plants. These observations are supplemented by critical reviews of the literature.

Genomics, the mapping of the entire genetic complement of an organism, is the new frontier in biology. This handbook on the statistical issues of genomics covers current methods and the tried-and-true classical approaches.

Studies of insect nervous systems have made an immense contribution to our understanding of how a brain works and the way that the connections between constituent neurons are formed during development, For the first time these studies are brought together in The neurobiology of an insect brain, a personal account by a leading experimental neurobiologist and zoologist. By concentrating largely on one insect, the locust, this book unravels the mechanisms by which a brain integrates the vast array of sensory information to generate appropriate movements and behaviour. It first describes the basic structure of an insect brain and how this complex structure is formed during embryonic development. The cellular properties of the different types of neurons, and the way they are altered by neurosecretions are then analysed with respect to the integrative actions of these neurons during behaviour. Finally, the various movements that an insect performs are investigated at the cellular level to illustrate particular features of the integrative processing. Throughout, the book emphasises how knowledge of these simpler nervous systems contributes to our understanding of more complex brains, and at the same time provides the functional synthesis into which future molecular and computational studies can be woven. The neurobiology of an insect brain is an important milestone in our search for unifying principles of brain organisation and will be essential reading for students and research workers in neurobiology, behaviour, and entomology. our understanding

Beyond Interdisciplinarity examines the broadening meaning of core concept across academic disciplines and other forms of knowledge. In this book, Associate Editor of The Oxford Handbook of Interdisciplinarity and internationally recognized scholar Julie Thompson Klein depicts the heterogeneity and boundary work of inter- and trans-disciplinarity in a conceptual framework based on an ecology of spatializing practices in transaction spaces, including trading zones and communities of practice. The book includes both "crossdisciplinary" work (encompassing multi-, inter-, and trans-disciplinary forms) as well as "cross-sector" work (spanning disciplines, fields, professions, government and industry, and communities). The first section of the book defines and explains boundary work, discourses of interdisciplinarity, and the nature of interdisciplinary fields. In the second section, Klein examines dynamics of working across disciplines, including communication, collaboration, and learning with concrete examples and lessons from research projects and programs that transcend traditional fields. The closing chapter examines reasons for failure and success then presents gateways to literature and other resources. Throughout the book, Klein emphasizes the roles of contextualization and historical change while factoring in the shifting relationship of disciplinarity and interdisciplinarity, ascendancy of transdisciplinarity, and intersections with other constructs including Mode 2 knowledge production, convergence, team science, and postdisciplinarity. The conceptual framework she provides also includes the role of boundary objects, agents, and organizations in brokering differences and creating for platforms for change. Klein further explains why translation, interlanguage, and a communication boundary space are vital to achieving intersubjectivity and collective identity. They foster not only pragmatics of negotiation and integration but also reflexivity, transactivity, and co-production of knowledge with stakeholders beyond the academy. Rhetorics of holism and synthesis compete with instrumentalities of problem solving and transgressive critiques. However, typical warrants today include complexity, contextualization, collaboration, and socially-robust knowledge. Crossing boundaries remains complex, but this book guides readers through the density of pertinent literature while expanding understandings of crossdisciplinary and cross-sector work.