Advances in Agronomy, Volume 149, the latest release in the series, continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied and exemplary of the abundant subject matter addressed by this long-running serial.

Advances in Clinical Chemistry, Volume 83, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest, most up-to-date technologies related to the field of clinical chemistry, with this release presenting comprehensive updates on Urinary Nucleosides and Deoxynucleosides, Locked Nucleic Acid Technology for Highly Sensitive Detection of Somatic Mutations in Cancer, Liquid Biopsy: From Basic Research to Clinical Practice, Circulating Tumor Cells and Implications of the Epithelial-to-Mesenchymal Transition, and more.

The identification and quantification of the widespread occurrence of trace organic chemicals at minute concentrations in the aqueous environment impacted by human activities is a result of rapid advances in environmental analytical chemistry. The body of knowledge regarding the characterization, fate and transport of these chemicals of emerging concern (CECs) in the natural water environment and engineered water treatment processes, as well as their toxicity, has grown substantially over the last two decades. Recently, the focus in the environmental chemistry community has shifted from these CEC parent compounds to the fate, transport, and toxicity of transformation products, which are generated through abiotic and biotic mechanisms in natural systems and during engineered advanced water treatment processes. This two-part book focuses on the studies and recent advancements towards the development of more harmonized strategies and workflows using non-target and suspects screening methods, including suitable bioassay approaches to assess the overall relevance of transformation products. Volume I covers the relevance of transformation products and international strategies to manage CECs, new methods for a comprehensive assessment of transformation products, and the fate and transport of transformation products in natural systems. This book is ideal for environmental scientists and engineers, particularly chemists, environmental engineers, public health officials, regulators, other chemistry-related professionals, and students.

WNT Signaling, Volume 153, the latest release in the Progress in Molecular Biology and Translational Science series, seeks to provide the most topical, informative, and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series provides readers with in-depth knowledge of important molecular biological aspects of organismal physiology and function, along with insights into how this knowledge may be applied to understand and ameliorate human disease. Each volume is edited by an internationally recognized expert who selects contributors at the forefront of a field.

Insect Epigenetics, Volume 53 provides readers with the latest interdisciplinary reviews on the topic. Updated chapters in this new release include Epigenetics in insects: Mechanisms, ecological outcomes, and evolutionary consequences, Nutrition and epigenetic change in insects, microRNAs in Drosophila insulin regulation, Epigenetic regulation of longevity in insects, Epigenetic influences on diapause, the Impact of parasites on epigenetics of their insect hosts, The molecular physiology of locust swarming behavior, The future of environmental epigenetics: insights using the clonal water-flea model, and. Epigenetics - A hidden target of insecticides. Led by volume editor Heleen Verlinden, this is an essential reference source for entomologists, zoologists, geneticists and insect chemists.

Advances in Agronomy, Volume 143 continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. This latest release brings new and updated information on Soil: The Forgotten Piece of the Water, Food, Energy Nexus, Humin: Its Composition and Importance in Soil Organic Matter, the Effects of Drought Stress on Morpho-Physiological Traits, Biochemical Characteristics, Yield and Yield Components in Different Ploidy Wheat: A Meta-Analysis, and a section on the Delineation of Soil Management Zones for Variable Rate Fertilization - A Review. Each volume in this series contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied, and exemplary of the abundant subject matter addressed by this long-running serial.

International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. This most current release in this highly cited series focuses on such timely topics as novel treatments in immunotherapy in breast cancer, chemokine receptor signaling and the hallmarks of cancer, tumor-targeting antibodies, and a section on mitochondrion and whether they are a common organelle for cell death. As always, readers will find the articles in this series to be of great value, with a high impact and average cited half-life of nine years. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. This great resource ranks high amongst scientific journals dealing with cell biology.

Hematopoietic Stem Cell Niche focuses on an individual organ, looking at the stem cells in the organ itself (if they exist), their niches, and how to use them alongside relevant methods and protocols. This series addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments, such as new data on disease and clinical applications. Specific chapters delve into the evolution of hematopoietic stem cell niches, the role of CNS in the regulation of HSCs, and targeting the bone marrow niche in hematological malignancies. In addition, video content illustrates protocols, transplantation techniques, and work with mice.

Advances in the Study of Behavior, Volume 49 provides users with the latest insights in this ever-evolving field. Users will find new information on a variety of species, including social behaviors in reptiles, the behavioral evidence of felt emotions, a section on developmental plasticity, a chapter on covetable corpses and plastic beetles and the socioecological behavior of burying beetles, and a section on the mechanisms of communication and cognition in chickadees. This volume makes another important contribution to the development of the field by presenting theoretical ideas and research findings to professionals studying animal behavior and related fields. Researchers in a variety of behavioral fields will find this longstanding series, initiated over 40 years ago, to be a go-to resource for the study of animal behavior.

Enzymes as Sensors, Volume 589, the latest release in the Methods in Enzymology series, covers a variety of topics, including advances in genetically coded fluorescent sensors, enzymes as sensors, and bioapplications of electrochemical sensors and biosensors. Users will find a comprehensive discussion of timely topics that presents a micro-level delivery of specific content related to the study of enzymes in sensors. New to this edition are highly specialized chapters on integrated strategies for gaining a systems level view of dynamic signaling networks, sensitive protein detection and quantification in paper-based microfluidics for point-of-care, and microneedle enzyme sensor arrays for continuous in vivo monitoring. This state-of-the-art series is ideal for those interested in the latest information on enzymology, with this edition focusing on sensors and their role in enzymes.

How Plants Communicate with Their Biotic Environment addresses how plants perceive the presence of organisms (other plants, microbes, insects and nematodes) living in their proximity, how they manage to be attractive when these organisms are friendly, and how they defend themselves from foes. Specific chapters delve into ecology and defense mechanisms, allelopathy and the role of allelochemicals in plant defense, plant signaling, and plant communication with microbes and animals, including herbivores. In addition, the book presents discussions on communication and its role in plant pollination. This comprehensive resource presents tactics that can be taken from the lab, to the bench, to the forest.

Chromatin Proteins and Transcription Factors as Therapeutic Targets, the latest volume in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

Neurotrophins, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions, and the biological actions of neurotrophins related to clinical conditions and disease. Each volume is thoroughly reviewed and focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances such as transmitters, cytokines, growth factors, and others.

Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology, containing comprehensive reviews of the most current research in applied microbiology. Users will find invaluable references and information on a variety of areas, including protozoan grazing of freshwater biofilms, metals in yeast fermentation processes, the interpretation of host-pathogen dialogue through microarrays, and the role of polyamines in bacterial growth and biofilm formation. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome.

J.B.S. Haldane (1892-1964) is widely appreciated as one of the greatest and most influential British scientists of the 20th century, making significant contributions to genetics, physiology, biochemistry, biometry, cosmology, and other sciences. More remarkable, then, is the fact that Haldane had no formal qualification in science. He made frequent appearances in the media, making pronouncements on a variety of poignant topics including mining disasters, meteorites, politics, and the economy, and was a popular scientific essay writer. Haldane also was famed for conducting painful experiments on himself, including several instances in which he permanently himself. A staunch Marxist and convert to Hinduism, Haldane lived a diverse, lively and interesting life that is still revered by today's science community. A biography of Haldane has not been attempted since 1968, and that book provided an incomplete account of the man's scientific achievement. "The Life and Works of J.B.S. Haldane" serves to fix this glaring omission, providing a complete biographical sketch written by Krishna Dronamraju, one of the last living men to have worked personally with Haldane. A new genre of biographies of 20th-century scientists has come into being, and thus far works have been written about men like Einstein, Oppenheimer, Bernal, Galton, and many more; the inclusion of Haldane within this genre is an absolute necessity. Dronamraju evaluates Haldane's social and political background, as well as his scientific creativity and accomplishments. Haldane embodies a generation of intellectuals who believed and promoted knowledge for its own sake, and that spirit of scientific curiosity and passion is captured in this biography.

Fly Models of Human Diseases provides users with a comprehensive survey on fly models of human diseases in the field of developmental biology. It is ideal for researchers in animal and plant development, and for students and professionals working in a variety of fields related to the topic.

Ticks of Trinidad and Tobago: An Overview explores tick species prevalent in Trinidad and Tobago (T&T), their distribution, associated pathogens, their effects on the host, and control methods. The book also reviews the basic biology of ticks. Ticks are known to parasitize a wide range of hosts including mammals, reptiles and birds. These parasites are of veterinary and public health significance since they are responsible for the spread of a number of pathogens to humans and animals. Worldwide, ticks are responsible for billions of dollars in losses in the livestock industry annually due to the effects of these pathogens. Based on review of the literature from more than five decades, twenty-three species of both hard and soft tick have been discovered on the twin-island republic with a greater number of species in Trinidad. Tick genera observed and recorded included Argas, Ornithodoros, Amblyomma, Dermacentor, Haemaphysalis, Ixodes, and Rhipicephalus species. The tick species found in Trinidad and Tobago parasitize both wild and domestic species. Hosts include bats, fowl, equids, wild and domestic ruminants, birds, rodents, marsupials, and a variety of reptiles such as toads, tortoises, and snakes. Based on geographical location, most tick species discovered in T&T have also been recorded in other Caribbean islands in the archipelago, North, Central and South America. Both soft and hard tick species found in T&T have also been implicated in a number of blood-borne pathogens including Borrelia, Ehrlichia, Babesia, Hepatozoon, Rickettsia, and Anaplasma.

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. This series covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

In the past few years, the subject of climate change has frequently garnered headlines due to the usual political controversy surrounding it. However, setting aside the argument as to whether climate change is a man-made effect or not, we cannot deny the fact that humanity has been discharging carbon increasingly into the atmosphere for centuries. Likewise, similar reports on the growing Great Pacific Garbage Patch-and the general accumulation of plastics everywhere-are alarming. Moreover, it has also been recently demonstrated that microplastics are finally entering the food webs which include the human consumer. Air, soil, and water pollution are increasing; in some ways forcing certain countries and governments to modify their politics, while also creating new opportunities and opening new niches for the marketing of products, such as air and water filters. With current techniques, it is not possible to completely eliminate all toxic and hazardous waste, which means that security deposits are necessary. Security deposits are storage areas prepared for certain toxic and dangerous industrial waste, so that its harmful properties cannot affect the natural environment and human health-at least, in any case, for a very long time. Due to their geomorphological composition, topography, and hydrographic conditions, there are sites that can be used as waste deposits, given their natural isolation and projected stability for hundreds of years. Thus, they become security deposits. In addition, every day new materials and construction techniques are developed that allow for a total isolation of the waste. A relatively new view in the material life cycle is the reuse of the generated waste as new resources. This helps to mitigate the cost increases in raw materials, energy, and regulations regarding waste disposal, which have caused the industry to rethink its production methods, leading to a better use of raw materials and energy. Clean technologies are those used by the industry to reduce the need for treatment or disposal of waste and to reduce the demand for raw materials, energy, and water. For the proper implementation of clean technologies, industries and municipalities must develop a deep understanding of their own processes and activities, and must analyze the characteristics of their equipment and make any possible modifications. An environmental evaluation of the situation provides suitable information on the efficiency of each component and its integration in the whole process, on the proportion of waste, on energy consumption, and on how to reorganize or modify to improve cost-efficiency in economic and environmental terms, which in a middle term view results in synergistic goals. With this concise introduction to the world of waste and pollutant treatment technologies, the editors believe it is clear that the solutions are to be developed on a case-by-case basis; because the larger the number of mixed pollutants, the more complex and intimated the process will be. This book presents a series of selected approaches that can be used to approach different cases, also depending upon budget and viability of a sustainable approach. This book serves as a source of information, triggers ideas, and fosters interaction between all the players taking action in sustainable development initiatives.

TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings.

Essential Clinical Anatomy of the Nervous System is designed to combine the salient points of anatomy with typical pathologies affecting each of the major pathways that are directly applicable in the clinical environment. In addition, this book highlights the relevant clinical examinations to perform when examining a patient's neurological system, to demonstrate pathology of a certain pathway or tract. Essential Clinical Anatomy of the Nervous System enables the reader to easily access the key features of the anatomy of the brain and main pathways which are relevant at the bedside or clinic. It also highlights the typical pathologies and reasoning behind clinical findings to enable the reader to aid deduction of not only what is wrong with the patient, but where in the nervous system that the pathology is.

ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike.

Laboratory Techniques in Rabies Diagnosis, Research and Prevention provides a basic understanding of the current trends in rabies. It establishes a new facility for rabies surveillance, vaccine and antibody manufacturing. It offers clarity about the choice of laboratory methods for diagnosis and virus typing, of systems for producing monoclonal and polyclonal antibodies and of methods for testing potency of vaccines and antibodies. The book covers advancements in the classical methods described as well as recent methods and approaches pertaining to rabies diagnosis and research.

The Two Selves takes the position that the self is not a "thing" easily reduced to an object of scientific analysis. Rather, the self consists in a multiplicity of aspects, some of which have a neuro-cognitive basis (and thus are amenable to scientific inquiry) while other aspects are best construed as first-person subjectivity, lacking material instantiation. As a consequence of its potential immateriality, the subjective aspect of self cannot be taken as an object and therefore is not easily amenable to treatment by current scientific methods. Klein argues that to fully appreciate the self, its two aspects must be acknowledged, since it is only in virtue of their interaction that the self of everyday experience becomes a phenomenological reality. However, given their different metaphysical commitments (i.e., material and immaterial aspects of reality), a number of issues must be addressed. These include, but are not limited to, the possibility of interaction between metaphysically distinct aspects of reality, questions of causal closure under the physical, the principle of energy conservation, and more. After addressing these concerns, Klein presents evidence based on self-reports from case studies of individuals who suffer from a chronic or temporary loss of their sense of personal ownership of their mental states. Drawing on this evidence, he argues that personal ownership may be the factor that closes the metaphysical gap between the material and immaterial selves, linking these two disparate aspects of reality, thereby enabling us to experience a unified sense of self despite its underlying multiplicity.

Even the most cursory survey of the chemical literature reveals that modern NMR spectroscopy has indeed fulfilled its potential as a powerful and indispensable tool for probing molecular structure, providing detail that is comparable to, and sometimes surpasses that, of X-ray crystallography. As NMR spectroscopy's 70th anniversary approaches, the diversity of chemical problems to which this technique can be applied continues to grow across many scientific fields. Beyond the laboratory setting, the technology underlying NMR is now a widely used and critical medical diagnostic technique, Magnetic Resonance Imaging (MRI). Unfortunately, the number of applications of NMR spectroscopy across so many STEM-related fields presents significant challenges in how best to introduce this powerful technique in meaningful ways at the undergraduate level. Inspired by the development of the field, and building upon the work of previous symposia and an ACS symposium series book on this topic (3), a symposium was developed, entitled "NMR Spectroscopy in the Undergraduate Curriculum," for the 239th American Chemical Society National Meeting in San Francisco. This book brings together all of the presenters who have been successful in developing and successfully integrating NMR spectroscopy pedagogy across their undergraduate curriculums. Their knowledge and experiences will aid readers who are interested in expanding and invigorating their own curriculum.