Advances in Applied Microbiology, Volume 114 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas relating to the topic of microbiology, with this release focusing on recent advances in the biosynthesis of isoprenoids in the engineered Saccharomyces cerevisiae.

What does Medial Frontal Cortex Signal During Behavior? Insights from Behavioral Neurophysiology, Volume 158 addresses and highlights a question that has remained central to cognitive and systems neuroscience since its inception, namely, what does the medial frontal cortex do? With insights from 17 of the fields leading teams of scientists, this volume attempts to address this question covering several topics with chapters including What do single unit responses in dorsal anterior cingulate cortex mean?, Social Processing by the Primate Medial Frontal Cortex, Medial frontal cortex and the temporal control of action, The midcingulate cortex and temporal integration, and more. Additional chapters cover The anterior cingulate cortex and event-based modulation of autonomic states, Integration of value and action in medial prefrontal neural systems, Secondary motor cortex: broadcasting and biasing animal's decisions through long-range circuits, The prefrontal cortex in social cognition, Representing task strategies in the medial prefrontal cortex, Prefrontal contributions to action control in rodents, From affective to cognitive processings: functional organization of the medial frontal cortex, and much more.

Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more.

As Crocodile strolls along wistfully, admiring beautiful creatures, she has one question: "Why, oh why, am I a crocodile?" Just as she's at her lowest, she encounters a blind monkey who introduces her to some newfound friends. Will Monkey be able to change Crocodile's view on the world and will she learn to love herself? A fun, rhyming children's book exploring emotional issues, such as low self-esteem and negative self-image. This lovely bedtime story, for toddlers, young children (and grown-ups!), is the perfect tool for discussing these all-important, ever-increasing feelings in a child-friendly way. The vibrant illustrations, with quirky extra details, will keep kids totally engaged and they will love joining in with the repetitive element of the book. Why, oh why, am I a crocodile? is the perfect addition to any child's bookshelf.

Advances in Genetics, Volume 107, provides the latest information on the rapidly evolving field of genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, with this new release including chapters on Advances in Asthma Genetics: Filling persistent gaps, Nutritional control of postembryonic development progression and arrest in Caenorhabditis elegans, Genetic determinants of climate-resilience traits in millets, Founder variants and population genomes - towards precision medicine, and much more.

Immunopathology of Celiac Disease, Volume 359 presents the latest release in this ongoing series on novel and widely studied aspects of celiac disease pathogenesis. Topics covered in this new volume include Omics of Celiac Disease, Implication of HLA genes in Celiac Disease, Macrophages & Dendritic Cells in Celiac Disease, Tight junction disruption in the development of celiac disease, Implication of epithelial cell dysfunction in CeD, Involvement of p31-p43 gluten peptide in the celiac disease related immune/inflammatory response, The biology of refractory celiac disease, Involvement of lncRNAs in Celiac disease pathogenesis, and more.

Evolutionary Developmental Biology, Volume 141 focuses on recent research in evolutionary developmental biology, the science studying how changes in development cause the variations that natural selection operate on. Several new hypotheses and models are presented in this volume, and these concern how homology may be properly delineated, how neural crest and placode cells emerged and how they formed the skull and jaw, and how plasticity and developmental symbiosis enable normal development to be regulated by environmental factors.

Enzymatic Plastic Degradation, Volume 648 in the Methods in Enzymology series, continues the legacy of this premier serial with chapters authored by leaders in the field. Chapters in this latest release include Evaluating plastic pollution and environmental degradation, Assessment methods for microplastic pollution in the oceans and fresh water, Exploring microbial consortia from various environments for plastic degradation, Characterization of filamentous fungi for attack on synthetic polymers via biological Fenton chemistry, Synthesis of radioactive-labeled nanoplastics for assaying the environmental (microbial) PS degradation, Exploring metagenome for plastic degrading enzymes, Cutinases from thermophilic bacteria (actinomycetes): from identification to functional and structural characterization, and much more.

Mechanisms and Therapy of Liver Cancer, Volume 149, presents the latest information on the incidence and mortality of liver cancer research and how it has gained significant momentum because of its direct causative association with obesity-induced fatty liver disease. The literature on liver cancer is moving fast with exciting, novel findings, providing new insights reflected in the following updated chapters: Introduction and molecular classification of HCC, Signaling Pathways in Liver Cancer, HCV and HCC, NASH and HCC, Microbiome and Metabolic Abnormalities in HCC, Systemic Therapy of Liver Cancer, Immunotherapy of Liver Cancer, and Desmoplastic Tumor Microenvironment and Intrahepatic Cholangiocarcinoma Progression: Mechanisms and Therapeutic Implications.

Advances in Agronomy, Volume 166, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Linkers in Biomacromolecules, Volume 647 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this updated release include chapters devoted to ser-gly linkers + models, sergGly- EAAAK linkers, Effect of crowding on linker behavior, Protathether. Experimental approach to quickly test different linkers in fusion proteins, Linkers in enzyme fusions/cascade catalysis, Linker dependence of avidity in multivalent interactions between disordered proteins, ER/K a-helix linker, The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design, Linker design in protein-based nanostructures, and much more. Linkers in Biomacromolecules, Volume 647 in the Methods in Enzymology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this updated release include chapters devoted to ser-gly linkers + models, sergGly- EAAAK linkers, Effect of crowding on linker behavior, Protathether. Experimental approach to quickly test different linkers in fusion proteins, Linkers in enzyme fusions/cascade catalysis, Linker dependence of avidity in multivalent interactions between disordered proteins, ER/K a-helix linker, The effect of chirality and steric hindrance on intrinsic backbone conformational propensities: tools for protein design, Linker design in protein-based nanostructures, and much more.

Epigenetics, Volume 151, the latest release in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of comprehensive topics, including Histone modifications in Alcohol use disorder, Non-coding RNAs: Regulators of alcohol actions, Epigenetics and Neuroinflammation in Psychiatric disorders, DNA methylation and Neurodevelopmental disease, Epigenetic inheritance in substance use disorders, THC, Epigenetics and schizophrenia, and more.

Methods in Enzymology, Volume 646, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this new release include Methods for Studying RNA condensation/granules in vitro, RNA Dynamics in Intracellular Condensates, Methods for Viscoelastic Characterization of Liquid and Gel Condensates, Incorporating Proteins into Complex Coacervates, Methods for Study of Liquid-Liquid Phase Coexistence in Proximity to Lipid Membranes, Preparation of and Solute Partitioning in Multiphase Coacervates, Reversible photocontrol of DNA coacervation, Enzymatic Control over Coacervation, and much more.

Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Part B, Volume 177 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, and more.

Advances in Agronomy, Volume 165, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors, with this release including chapters on Urban Anthropogenic Soils - A Review, Epichloe spp. And Serendipita indica Endophytic Fungi: Functions in Plant-Soil Relations, Heating Up a Cold Case: Applications of Analytical Pyrolysis GC/MS to Assess Molecular Biomarkers in Peat, The problem with "Apparent Electrical Conductivity" in Soil Electromagnetic Induction Studies, and more.

Professor H James Birx shows how the never-ending controversy of human evolution came to be. He details the events that caused thinkers like Charles Darwin to develop his theory of evolution, and what ideas caused some people to reconcile a somewhat mystical theology with a concrete model of the universe. He tells you how Darwin's work infuriated everybody from "God-fearing" Christians to the church hierarchies. Birx explains how scientific advances and philosophical arguments have made beliefs about divine intervention as the origin of man a moot point. He shows how creationism ignores proven scientific facts, and how human evolution remains a much sounder truth. You will read how some western religions are starting to accept evolution as the process which creates life on earth. You will also learn why scientific evolution and creationism have not been accepted together and how bold attempts to merge the two ideas have failed miserably.

A Best Book of 2020: The Washington Post * NPR * Chicago Tribune * Smithsonian A "remarkable" (Los Angeles Times), "seductive" (The Wall Street Journal) debut from the new cohost of Radiolab, Why Fish Don't Exist is a dark and astonishing tale of love, chaos, scientific obsession, and--possibly--even murder. "At one point, Miller dives into the ocean into a school of fish...comes up for air, and realizes she's in love. That's how I felt: Her book took me to strange depths I never imagined, and I was smitten." --The New York Times Book Review David Starr Jordan was a taxonomist, a man possessed with bringing order to the natural world. In time, he would be credited with discovering nearly a fifth of the fish known to humans in his day. But the more of the hidden blueprint of life he uncovered, the harder the universe seemed to try to thwart him. His specimen collections were demolished by lightning, by fire, and eventually by the 1906 San Francisco earthquake--which sent more than a thousand discoveries, housed in fragile glass jars, plummeting to the floor. In an instant, his life's work was shattered. Many might have given up, given in to despair. But Jordan? He surveyed the wreckage at his feet, found the first fish that he recognized, and confidently began to rebuild his collection. And this time, he introduced one clever innovation that he believed would at last protect his work against the chaos of the world. When NPR reporter Lulu Miller first heard this anecdote in passing, she took Jordan for a fool--a cautionary tale in hubris, or denial. But as her own life slowly unraveled, she began to wonder about him. Perhaps instead he was a model for how to go on when all seemed lost. What she would unearth about his life would transform her understanding of history, morality, and the world beneath her feet. Part biography, part memoir, part scientific adventure, Why Fish Don't Exist is a wondrous fable about how to persevere in a world where chaos will always prevail.

Developed for the new International A Level specification, these new resources are specifically designed for international students, with a strong focus on progression, recognition and transferable skills, allowing learning in a local context to a global standard. Recognised by universities worldwide and fully comparable to UK reformed GCE A levels. Supports a modular approach, in line with the specification. Appropriate international content puts learning in a real-world context, to a global standard, making it engaging and relevant for all learners. Reviewed by a language specialist to ensure materials are written in a clear and accessible style. The embedded transferable skills, needed for progression to higher education and employment, are signposted so students understand what skills they are developing and therefore go on to use these skills more effectively in the future. Exam practice provides opportunities to assess understanding and progress, so students can make the best progress they can.

Flora of North America, Volume 22, is the first of five volumes covering monocots in North America, north of Mexico. The volume comprises of many groups of aquatic plants and the North American relatives of groups that have their greatest number of species located in the New World tropics. These include: the rush family (Juncaceae); cat-tails (Typhaceae); spiderworts (Commelinaceae); aroids (Araceae), and pondweeds (Potamogetonaceae). This volume includes thirty families, representing a diverse range of plant forms from marine Zosteraceae (eel-grasses) to stately Arecaceae (palms), and the naturalised exotic Zingiberaceae (gingers), Heliconiaceae (heliconias), and Musaceae (bananas).

The study of attention is central to psychology. In this work, Michael Posner, a pioneer in attention research, presents the science of attention in a larger social context, which includes our ability to voluntarily choose and act upon an object of thought. The volume is based on fifty years of research involving behavioral, imaging, developmental, and genetic methods. It describes three brain networks of attention that carry out the functions of obtaining and maintaining the alert state, orienting to sensory events, and regulating responses. The book ties these brain networks to anatomy, connectivity, development, and socialization and includes material on pathologies that involve attentional networks, as well as their role in education and social interaction.

This book addresses the ethical and political questions flowing from the vastly increased possibilities to manipulate the genetic properties of organisms, including human beings. Due to the great complexity of the scientific fields involved, these questions are framed and answered mostly by scientific experts. But the new technological possibilities and social practices connected with genetic manipulation intrude into domains that for a long time have been the provenance of religious and secular worldviews and touch upon deep-seated convictions and emotions. Moreover they are strongly influenced by economic and political interests. As a consequence, questions of scientific truth and technical control are getting more and more "mixed up" with questions regarding values and interests. Against this background, this book starts from the premise that neither clinging to the idea of value-neutral, disinterested science, nor the complete abandonment of this idea in favour of postmodern relativism will be of much help here. Instead the different contributions to this book explore the idea of a 'lingua democratica' for the life sciences and sketch the contours of this notion by focusing on a broad range of conceptual and practical issues in the field of genomics.

It is well known that the class of steroid hormones known as estrogens have powerful effects on organs related to reproduction such as the uterus and the breast. What is less well known is that estrogens also profoundly modulate brain function and behavior. Estrogens, such as estradiol, can occur in brain as the result of ovarian secretion of the hormone into the blood that then finds its way to the brain. In male vertebrates, the testes secrete androgens, such as testosterone, into the blood and this class of steroid hormones can be converted into estrogens in the brain via the action of the enzyme aromatase which is expressed in the male brain in many species. Finally estradiol can be synthesized de novo from cholesterol as it has been shown in a variety of species that all the enzymes required to synthesize estrogens are expressed in the brain. This book collects chapters by experts in the field that considers, how estradiol is synthesized in the brain and what its effects are on a variety of behaviors. Special attention is paid to the enzyme aromatase that is distributed in discrete regions of the brain and is highly regulated in a sex specific and seasonal specific manner. Recently it has become clear that estrogens can act in the brain at two very different time scales, one is rather long lasting (days to weeks) and involves the modulation of gene transcription by the hormone-receptor complex. A second mode of action is much quicker and involves the action of estrogens on cell membranes that can result in effects on second messenger systems and ultimately behavior within minutes. Thus this book highlights novel views of estrogen action that are still under-appreciated namely that estrogens have significant effects on the male brain and that they can act on two very different times scales. This volume will be of interest to both basic researchers and clinicians interested in the action of estrogens.