Modern Approaches in Drug Discovery, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Target Identification and Validation, Cell Painting/High Content Imaging, Target ID using chemical probes, Mining the microbiome for targets, Data driven approaches for diversity and drug-likeness, Affinity-based screening, Fragment screening (X-ray), Array-based approaches, Hit-to-lead: assessment and improvement of drug-like properties, Hit assessment and prioritization, Lead Optimization: fine tuning and risk mitigation, and more.

Plant Transporters, Volume 87, the latest release in the Advances in Botanical Research series, brings together the experiences and critical information teachers, researchers and managers must consider from scientific and legal points-of-view as they relate to biotechnology. New chapters in this updated volume include sections on P-type ATPases, ABC transporters, Nitrate transport, Metal transporters, Hormone transporters, Plant aquaporins, Ion channel regulation in guard cells, Ion transport in pollen tube growth, Xylem loading under stress, and Transporters during arbuscular mycorrhizal symbiosis.

Advances in Applied Microbiology, Volume 105 continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas, with this updated volume including chapters covering The Genus Macrococcus: an insight into its evolution, biology and relationship with Staphylococcus, The use of electrobiochemical reactors for in vitro and in vivo metabolic engineering, Advances in the Microbial Ecology of Biohydrometallurgy, Optimizing yeast alcoholic fermentations, Methods to reduce spoilage and microbial contamination of plant produce, Microbial Diversity and Functional Analysis, and more.

Membranes in Pulmonary Vascular Disease, Volume 82, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters from recognized experts on topics such as Sphingolipids in Vascular Lung Disease, Endothelial Glycocalyx, Cholesterol Regulation of Endothelial Cell Calcium Homeostasis in Pulmonary Hypertension, Mechanosensitive Channels and Gap Junction Channels in EC, Endothelial Protrusions in Junctional Integrity and Barrier Function, Cortical Actin Dynamics in Endothelial Permeability, Endothelial Microparticles and Exosomes, Store Operated TRP Channels and Endothelial Responses, and Caveolin and Endothelial NO signaling.

New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Genes Biochemistry and Applications consolidates the most widely used genetic methods available, bringing together the fields of biochemistry, biotechnology, and microbiology. The chapters outlined give clear and concise direction on both standard and applied microbial genetic improvements, presenting undergraduates, postgraduates, and researchers with the latest developments in microbial gene technology. In addition, the book describes the background and usefulness of each experiment in question. All chapters covered in the book are derived from current peer-reviewed literature as accepted by the international scientific community.

The Opioid System as the Brain's Interface between Cognition and Motivation, Volume 239, focuses on the opioid system as the interface between the brain's cognitive and motivational systems. As the opioid system is widely distributed through the brain, particularly in areas implicated in cognition (hippocampus, prefrontal cortex, claustrum, thalamus) and motivation (hypothalamus, amygdala, pontine nuclei, periaqueductal gray and medulla), this book provides chapters that address ongoing research on topics such as the Brain's cognitive system, the Brain's motivational system, Antidepressant prescription patterns, Antidepressant-like effects of opioid receptor modulators, the Behavioral effects of antidepressant and anxiolytic drugs, and more.

The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics.

Advances in Agronomy continues to be recognized as a leading reference and first-rate source for the latest research in agronomy. Each volume contains an eclectic group of reviews by leading scientists throughout the world. As always, the subjects covered are rich, varied, and exemplary of the abundant subject matter addressed by this long-running serial.

Nitric Oxide and Other Small Signalling Molecules, Volume 73, the latest release in the Advances in Microbial Physiology series, continues the long tradition of topical, important, cutting-edge reviews in microbiology. The book contains updates in the field, with comprehensive chapters covering Nitric Oxide and Urinary Pathogens, Antibiotic Lethality and pH Homeostasis, Antimicrobial Strategies for Avian Pathogens and Bioactive Peptides from Marine Sources for Biotechnological Applications, and more.

Advances in Virus Research, Volume 102, the latest release in this esteemed series, contains new, informative updates on the topic. First published in 1953, this series covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology. Updates to this release includes sections on the Development of model systems for plant rhabdovirus research, Dichorhaviruses and their mite vectors, Molecular modelling for better understanding Cucumovirus pathology, Modification of host-insect reactions by viruses, Gene Gangs of the Chloroviruses: Conserved Co-linear Monocistronic Gene Sets, Virus disease control by transgenic approach and attenuated virus, Virus effectors, Tobamovirus evolution, and more.

Enzymes Conjugated to Graphene, Volume 609 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on Enzyme immobilization, Detection of Urea, Enzyme immobilization Enzyme immobilization, PAMAM dendrimer modified reduced graphene oxide post functionalized by horseradish peroxidase for biosensing H2O2, HRP immobilized for LEV detection, Enzyme immobilization, Graphene biocatalysts, Enzyme immobilization, Interactions, Enzyme immobilization, GQD, Enzyme Immobilization, and Enzyme immobilization on functionalized graphene oxide nanosheets.

Biology of T Cells: Part A, Volume 341, the latest release in the International Review of Cell and Molecular Biology, reviews and details current advances in cell and molecular biology. The IRCMB series maintains the highest standard by publishing timely topics authored by prominent cell and molecular biologists. Specialized topics in this release include TCR signaling: Molecules and mechanisms, TCR diversity: Purpose and generation, Transcriptional programs underlying T-cell differentiation and function, Surface phenotypes of CD8+ and CD4+ T cells, Co-stimulation and co-inhibition in CD8+ and CD4+ T cells, Regulated cell death and T cells, Molecular mechanisms behind T-cell priming by DCs, and more.

Cell Volume Regulation and Fluid Secretion, Volume 81, the latest release in the Current Topics in Membranes series highlights new advances in the field, with this new volume presenting interesting chapters on General principles of cell volume regulation, Cell volume maintenance: water and salt homeostasis, The search for ubiquitous cell volume sensor: the role of plasma membrane and cytoplasmic hydrogel, More than membranes, Cellular and membrane biomechanics of CVR response, Molecular identities of volume-regulatory anion channels, Molecular biology and physiology of volume-regulated anion channel (VRAC), the Role of WNKs in the modulation of intracellular chloride, amongst other topics.

Integrated Population Biology and Modeling: Part A offers very complex and precise realities of quantifying modern and traditional methods of understanding populations and population dynamics. Chapters cover emerging topics of note, including Longevity dynamics, Modeling human-environment interactions, Survival Probabilities from 5-Year Cumulative Life Table Survival Ratios (Tx+5/Tx): Some Innovative Methodological Investigations, Cell migration Models, Evolutionary Dynamics of Cancer Cells, an Integrated approach for modeling of coastal lagoons: A case for Chilka Lake, India, Population and metapopulation dynamics, Mortality analysis: measures and models, Stationary Population Models, Are there biological and social limits to human longevity?, Probability models in biology, Stochastic Models in Population Biology, and more.

Epigenetic Principles of Evolution, Second Edition, fully examines the causal basis of evolution from an epigenetic point-of-view. By revealing the epigenetic uses of the genetic toolkit, this work demonstrates the primacy of epigenetic mechanisms and epigenetic information in generating evolutionary novelties. The author convincingly supports his theoretical perspective with examples from varied fields of biology, emphasizing changes in developmental pathways as the basic source of evolutionary change in metazoans. Users will find a broader view of the epigenetic mechanisms of evolution, moving beyond conventional changes in epigenetic structures, such as DNA methylation, histone modifications, and patterns of miRNA, sRNA, and mRNA expression. This second edition is thoroughly updated to reflect new evidence and developing theories in the field of evolutionary epigenetics. New and revised chapters speak to the epigenetic basis of heredity, epigenetic regulation of animal structure and homeostasis, neural manipulation of gene expression, central control of gametogenesis, epigenetic control of early development, the origin of epigenetic information, evolutionary changes in response to environmental stressors, epigenetics of sympatric evolution, and the epigenetics of the Cambrian explosion, among other topics.

Darwin's Pangenesis and its Rediscovery Part B explores Darwin's Pangenesis, an expanded cell theory and unified theory of heredity and variation from over 150 years ago that strengthened his theory of evolution and explained many phenomena of life. Now, new discoveries on circulating DNA, mobile RNAs, prions and extracellular vesicles are providing striking evidence for the chemical existence of Darwin's imaginary gemmules. In addition, new evidence for the inheritance of acquired characters, graft hybridization, and many other phenomena that Pangenesis supposedly explains are progressing, and are hence explored in this comprehensive volume. Specific chapters in this new volume include Darwin and Mendel: The Historical Connection, Darwin's Pangenesis and Graft Hybridization, Darwin's Pangenesis and Medical Genetics, Darwin's Pangenesis and Certain Anomalous Phenomena, and Natural Selection and Pangenesis: The Darwinian Synthesis.

Radical SAM Enzymes, Volume 606, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on the Characterization of the glycyl radical enzyme choline trimethylamine-lyase and its radical S-adenosylmethionine activating enzyme, Diphathimide biosynthesis, Radical SAM glycyl radical activating enzymes, Radical SAM enzyme BioB in the biosynthesis of biotin, Biogenesis of the PQQ cofactor, Role of MoaAC in the biogenesis of the molybdenum cofactor, Biosynthesis of the nitrogenase cofactor, Bioinformatics of the radical SAM superfamily, The involvement of SAM radical enzymes in the biosynthesis of methanogenic coenzymes, methanopterin and coenzyme F420, and more.

Cerebral Lateralization and Cognition: Evolutionary and Developmental Investigations of Motor Biases, Volume 238, the latest release in the Progress in Brain Research series, discusses interdisciplinary research on the influence of cerebral lateralization on cognition within an evolutionary framework. Chapters of note in this release include Evolutionary Perspectives: Visual/Motor Biases and Cognition, Manual laterality and cognition through evolution: An archeological perspective, Laterality in insects, Motor asymmetries in fish, amphibians and reptiles, Visual biases and social cognition in animals, Mother and offspring lateralized social interaction across animal species, Manual bias, personality and cognition in common marmosets and other primates, and more.

Neuroepigenetics and Mental Illness, Volume 158, the latest release in the Progress in Molecular Biology and Translational Science series, seeks to provide the most topical, informative, and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series seeks to provide readers with in-depth knowledge of important molecular biological aspects of organismal physiology and function, with this release focusing on Neuroepigenetics in mental illness, Neuroepigenetics of development and neurodevelopmental disorder, Neuroepigenetics of aging and age-related neurodegenerative disorders, Neuroepigenetics of prenatal psychological stress, Neuroepigenetics of the HPA axis, Neuroepigenetics of the serotonergic system, and more.

Microfluidics in Cell Biology Part A: Volume 146, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections on Cell monolayers/spheroids, Collective migration in microtubes, Leukocyte adhesion dynamics on endothelial monolayers under flow, Constrained spheroid for perfusion culture, Cells in droplet arrays, Heart on chips, Kidney on chips, Liver on chips and hepatic immune responses, Gut on chips, 3D microvascular model-based lymphoma model, Blood brain barrier on chips, Multi-organ-on-a-chip for pharmacokinetic analysis, Cancer immunotherapy on chips, and more.

Darwin's Pangenesis and Its Rediscovery Part A highlights the findings of Darwin's Pangenesis, an expanded cell theory and unified theory of heredity and variation that strengthened his theory of evolution and explained many phenomena of life. Now, new advances and the discovery of circulating cell-free DNA, mobile RNAs, prions and extracellular vesicles are providing new breakthroughs, thus increasing evidence on the inheritance of acquired characters, graft hybridization, and many other phenomena that Pangenesis suggests. Sections of note in this volume include the rationale, criticisms, influence and recent molecular evidence of Darwin's Pangenesis, as well as its relation to the inheritance of acquired characters, which is often included under the blanket term "transgenerational epigenetic inheritance."

Dehydroepiandrosterone, Volume 108, the latest release in the Vitamins and Hormones series first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics such as Dehydroepiandrosterone Research: Past, Current and Future, Astrocyte Neuroprotection and Dehydroepiandrosterone, Mutation of HSD3B2 Gene and Fate of Dehydroepiandrosterone, Autophagy and Autophagic Cell Death: Uncovering New Mechanisms Whereby Dehydroepiandrosterone Promotes Beneficial Effects on Human Health, Dehydroepiandrosterone and Cardiovascular Disease, Dehydroepiandrosterone and Experimental Osteoarthritis, The Role of Dehydroepiandrosterone (DHEA) in Skeletal Muscle, Mechanism of Action of Dehydroepiandrosterone, and more.

Advances in Marine Biology, Volume 79, the latest release in a series that has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963, updates on many topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology and biological oceanography. This latest release includes a review of patterns of multiple paternity across sea turtle rookeries, parasites and pathogens in seabirds, progress in marine genomics and bioinformatics, the rise of sea turtle research and conservation, and the potential impacts of offshore oil and gas activities on deep-sea sponges and the habitats they form.

G Protein-Coupled Receptors: Emerging Paradigms in Activation, Signaling and Regulation, Part A, Volume 337 in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. This new release includes comprehensive sections on the classical paradigms of GCPR signaling and regulation, the family of small GTPases: Beyond heterotrimeric G proteins, GPCR endocytosis: Arrestins, arrestin-like proteins, signaling from internalized G Protein-Coupled Receptors, GPCR kinases, and more.

Therapeutic Proteins and Peptides, Volume 112 in an ongoing series promotes further research in the discovery of new therapeutic targets that can be affected by therapeutic proteins and peptides to cure or manage symptoms of human diseases, with this release focusing on the Rational Design of Stable Liquid Formulations of Biopharmaceuticals, Formulation strategies for peptides, proteins and antibodies using nanotechnology, the Solution structural dynamics of therapeutic peptides and their adsorption on plasmonic nanoparticles, Enzymatic approaches of protein-polymer conjugation, Chimeric small antibody fragments as a strategy to deliver therapeutic payloads, Smart cell-penetrating peptide-based techniques for cytoplasmic delivery of therapeutic macromolecules, and more.