Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers.

Intellectual property (IP) is a key component of the life sciences, which is becoming one of the most dynamic and innovative fields of technology today. At the same time, the relationship between IP and the life sciences is raising new public policy dilemmas. The Research Handbook on Intellectual Property and the Life Sciences comprises contributions by leading experts from academia and industry that confront current debates and controversies at the intersection of IP and the life sciences through in-depth analyses of key topics including pharmaceuticals, diagnostics and genes, plant innovations, stem cells, the role of competition law and access to medicines. The first section of this book highlights the importance of IP for medicines and pharmaceuticals, discussing topics including gene patents, and the second section deals with agricultural sector issues such as plant innovations. The third section of the book covers areas of research and development in the life sciences, such as stem cell research, and raises questions about incorporating ethical considerations into patent law. While the primary focus of the book is on Europe and the United States, the fourth section includes country-specific case studies on Australia, Brazil, China, India, Japan, Kenya, South Africa and Thailand to provide a truly international perspective. This Research Handbook is written in an accessible style that will appeal to intellectual property law scholars, practitioners and experts in the life sciences who are interested in the legal implications of IP for the life sciences. Contributors include: J. Allred, T. Avafia, C. Chiarolla, D. Degen, J.M. Golden, S. Gosh, M. Graf, J. Harrington, A. Heinemann, M.D. Janis, M. Kock, D. Matthews, C.R. McManis, A. Metzger, T. Minssen, C. Mund, P. Paranagua, A. Plomer, S. Ragavan, M. Rimmer, C. Seitz, T. Takenaka, G. Van Overwalle, D. Wachter, G. Wurtenberger, Z. Xinfeng, B. Yagi, B. Yao, H. Zech

Since its appearance in 1859, Darwin's long awaited treatise in genetic biology had received reviews both favorable and damning. Thomas Huxley and Samuel Wilberforce presented arguments for and against the theory in a dramatic and widely publicized face-off at the 1860 meeting of the British Association for the Advancement of Science in Oxford. Their encounter sparked a vigorous, complex debate that touched on a host of issues and set the stage for the Royal Society s consideration of whether or not they ought to award Darwin the Copley Medal, the society s most prestigious prize. While the action takes place in meetings of the Royal Society, Great Britain s most important scientific body, a parallel and influential public argument smoldered over the nature of science and its relationship to modern life in an industrial society. A significant component of the Darwin game is the tension between natural and teleological views of the world, manifested especially in reconsideration of the design argument, commonly known through William Paley s Natural Theology; or, Evidences of the Existence and Attributes of the Deity (1802) and updated by Wilberforce. But the scientific debate also percolated through a host of related issues: the meaning and purposes of inductive and hypothetical speculation in science; the professionalization of science; the implications of Darwinism for social reform, racial theories, and women s rights; and the evolving concept of causation in sciences and its implications for public policy. Because of the revolutionary potential of Darwin s ideas, the connections between science and nearly every other aspect of culture became increasingly evident. Scientific papers and laboratory demonstrations presented in Royal Society meetings during the game provide the backdrop for momentous conflict, conflict that continues to shape our perceptions of modern science.

Reacting to the Past is a series of historical role-playing games that explore important ideas by re-creating the contexts that shaped them. Students are assigned roles, informed by classic texts, set in particular moments of intellectual and social ferment.

An award-winning active-learning pedagogy, Reacting to the Past improves speaking, writing, and leadership skills, promotes engagement with classic texts and history, and builds learning communities. Reacting can be used across the curriculum, from the first-year general education class to capstone experiences. A Reacting game can also function as the discussion component of lecture classes, or it can be enlisted for intersession courses, honors programs, and other specialized curricular purposes."

The first comprehensive book focusing on synthesis and applications of macrocyclic polyamines and their derivatives Macrocyclic polyamines are a class of widely used important compounds. This is the first book that systematically summarizes the synthesis and applications of macrocyclic polyamines and their analogues, including the properties and synthetic methods of macrocyclic polyamines, chemical nucleases based on macrocyclic polyamines, the derivatives of macrocyclic polyamines as nano-vector materials, macrocyclic polyamines derivatives for bio-imaging, chemical sensors based on macrocyclic polyamines, and other applications of macrocyclic polyamines. Macrocyclic Polyamines: Synthesis and Applications includes most of the studies involving macrocyclic polyamines and their derivatives, and may be used as a reference for the researchers in related fields. It offers in-depth coverage of cyclization modes; special procedures for tetraza macrocyclic compounds; diacids-diamines condensation; oxidative DNA cleaving by macrocyclic polyamines; lipids with cationic MPA headgroups; the derivatives of DOTA, DO3A, and PCTA; receptors for anions; sensors for bioactive molecules; macrocyclic polyamines for solvent extraction and membrane transport of amino acids and their derivatives, electrophoretic separation, and open-tubular CEC; and much more. ?The first book that systematically summarizes the chemistry of macrocyclic polyamines and their derivatives in terms of synthetic methods for their preparation, functionalization, and application in the main fields of chemical sensors, chemical nucleases, drug-delivery, bio-imaging and vector materials ?Provides a comprehensive reference for the researchers working on macrocyclic polyamines ?Offers train of thought in related research fields such as organic chemistry, coordination chemistry, analytical chemistry, supramolecular chemistry, biomaterials, etc. Macrocyclic Polyamines: Synthesis and Applications will not only provide a reference for the researchers working on macrocyclic polyamines, but also offer opportunities for researchers in related research fields to understand the benefits of these key compounds.

Key features: Organised and centred around analysis techniques, not traditional Mechanics and E&M. Presents a unified approach, in a different order, meaning that the same laboratories, equipment, and demonstrations can be used when teaching the course. Demonstrates to students that the analysis and concepts they are learning are critical to the understanding of biological systems.

This book provides an introduction to the significant role of physics in evolution, based on the ideas of matter and energy resource flow, organism self-copying, and ecological change. The text employs these ideas to create quantitative models for important evolutionary processes. Many fields of science and engineering have come up against the problem of complex design-when details become so numerous that computer power alone cannot make progress. Nature solved the complex-design problem using evolution, yet how it did so has been a mystery. Both laboratory experiments and computer-simulation attempts eventually stopped evolving. Something more than Darwin's ideas of heredity, variation, and selection was needed. The solution is that there is a fourth element to evolution: ecological change. When a new variation is selected, this can change the ecology, and the new ecology can create new opportunities for even more new variations to be selected. Through this endless cycle, complexity can grow automatically. This book uses the physics of resource flow to describe this process in detail, developing quantitative models for many evolutionary processes, including selection, multicellularity, coevolution, sexual reproduction, and the Serengeti Rules. The text demonstrates that these models are in conceptual agreement with numerous examples of biological phenomena, and reveals, through physics, how complex design can arise naturally. This will serve as a key text on the part physics plays in evolution, and will be of great interest to students at the university level and above studying biophysics, physics, systems biology, and related fields.

* Investigates new findings on the predictive brain and what these insights mean for autism and current interventions. * The book has already sold over 2000 copies within 7 months of publishing in Dutch * Peter Vermeulen has established himself as an expert in autism writing, his last books selling thousands of copies and being translated into 10 languages and 5 languages each.

This pocket-sized, easy-to-use guide to the birds of Zambia features 425 birds likely to be seen in the region, plus a few ‘specials’ sought after by birders. It is an invaluable introduction and guide for visitors to Zambia with its 20 national parks and 42 Important Bird Areas.

Features include:

• An informative introduction to birding in the region, including habitat descriptions and a glossary
• Full-colour photographs illustrating diagnostic features and plumage differences
• Concise identification text, including key ID pointers, call description and favoured habitat of each species
• Up-to-date distribution maps.

Lightweight and handy for use in the field, this will be an excellent guide for anyone interested in the birds of Africa.

2020 Next Generation Indie Book Awards Winner - Science Category 2018 Forward Indies Finalist - Psychology Category Why are we obsessed with the things we want only to be bored when we get them? Why is addiction perfectly logical to an addict? Why does love change so quickly from passion to indifference? Why are some people die-hard liberals and others hardcore conservatives? Why are we always hopeful for solutions even in the darkest times-and so good at figuring them out? The answer is found in a single chemical in your brain: dopamine. Dopamine ensured the survival of early man. Thousands of years later, it is the source of our most basic behaviors and cultural ideas-and progress itself. Dopamine is the chemical of desire that always asks for more-more stuff, more stimulation, and more surprises. In pursuit of these things, it is undeterred by emotion, fear, or morality. Dopamine is the source of our every urge, that little bit of biology that makes an ambitious business professional sacrifice everything in pursuit of success, or that drives a satisfied spouse to risk it all for the thrill of someone new. Simply put, it is why we seek and succeed; it is why we discover and prosper. Yet, at the same time, it's why we gamble and squander. From dopamine's point of view, it's not the having that matters. It's getting something-anything-that's new. From this understanding-the difference between possessing something versus anticipating it-we can understand in a revolutionary new way why we behave as we do in love, business, addiction, politics, religion-and we can even predict those behaviors in ourselves and others. In The Molecule of More: How a Single Chemical in Your Brain Drives Love, Sex, and Creativity-and will Determine the Fate of the Human Race, George Washington University professor and psychiatrist Daniel Z. Lieberman, MD, and Georgetown University lecturer Michael E. Long present a potentially life-changing proposal: Much of human life has an unconsidered component that explains an array of behaviors previously thought to be unrelated, including why winners cheat, why geniuses often suffer with mental illness, why nearly all diets fail, and why the brains of liberals and conservatives really are different.

Sample Sizes for Clinical Trials, Second Edition is a practical book that assists researchers in their estimation of the sample size for clinical trials. Throughout the book there are detailed worked examples to illustrate both how to do the calculations and how to present them to colleagues or in protocols. The book also highlights some of the pitfalls in calculations as well as the key steps that lead to the final sample size calculation. Features: Comprehensive coverage of sample size calculations, including Normal, binary, ordinal, and survival outcome data Covers superiority, equivalence, non-inferiority, bioequivalence and precision objectives for both parallel group and crossover designs Highlights how trial objectives impact the study design with respect to both the derivation of sample formulae and the size of the study Motivated with examples of real-life clinical trials showing how the calculations can be applied New edition is extended with all chapters revised, some substantially, and four completely new chapters on multiplicity, cluster trials, pilot studies, and single arm trials The book is primarily aimed at researchers and practitioners of clinical trials and biostatistics, and could be used to teach a course on sample size calculations. The importance of a sample size calculation when designing a clinical trial is highlighted in the book. It enables readers to quickly find an appropriate sample size formula, with an associated worked example, complemented by tables to assist in the calculations.

Discover the fascinating stories behind 300 species of fungi and understand the world of mushrooms like never before! Did you know that fungi put the fizz in champagne and the flavour in chocolate? Fungi is everywhere we look: in a forest, under the sea, and in the kitchen. In this beautiful book, leading fungal biologists Lynne Boddy and Ali Ashby bring you closer to 300 species of mushrooms and lichens through fascinating facts, mushroom datasets, and detailed illustrations. Discover some of the fastest speeds in nature, specimens that glow in the dark, and fungi that clean up oil spills. Humans have had a close relationship with mushrooms for thousands of years - from using the shiitake for healing, to telling stories of enchanted fairy rings, and cooking gourmet dishes with rare specimens. Bringing together technology, medicine, food, culture, and nature, this fascinating book will open your eyes to the wonders of the hidden kingdom all around us.

In this compelling book, Rien Fertel tells the story of humanity's complicated and often brutal relationship with the brown pelican over the past century. This beloved bird with the mythically bottomless belly-to say nothing of its prodigious pouch-has been deemed a living fossil and the most dinosaur-like of creatures. The pelican adorns the Louisiana state flag, serves as a religious icon of sacrifice, and stars in the famous parting shot of Jurassic Park, but, most significantly, spotlights our tenuous connection with the environment in which it flies, feeds, and roosts-the coastal United States. In 1903, Theodore Roosevelt inaugurated the first national wildlife refuge at Pelican Island, Florida, in order to rescue the brown pelican, among other species, from the plume trade. Despite such protections, the ubiquity of synthetic "agents of death," most notably DDT, in the mid-twentieth century sent the brown pelican to the list of endangered species. By the mid-1960s, not one viable pelican nest remained in all of Louisiana. Authorities declared the state bird locally extinct. Conservation efforts-including an outlandish but well-planned birdnapping-saved the brown pelican, generating one of the great success stories in animal preservation. However, the brown pelican is once again under threat, particularly along Louisiana's coast, due to land loss and rising seas. For centuries, artists and writers have portrayed the pelican as a bird that pierces its breast to feed its young, symbolizing saintly piety. Today, the brown pelican gives itself in other ways, sacrificed both by and for the environment as a bellwether bird-an indicator species portending potential disasters that await. Brown Pelican combines history and first-person narrative to complicate, deconstruct, and reassemble our vision of the bird, the natural world, and ourselves.

With over 100 colour photographs and illustrations, Raising Resilient Bees is the comprehensive source for new and experienced beekeepers, offering a sustainable, natural and repeatable model of care for hive health and production. Global pests and diseases present an unprecedented challenge for the modern honey bee. Hobby and commercial beekeepers alike continue to experience troubling rates of mortality for their colonies, with potentially deleterious consequences for the stability of our wider ecosystems and overall food security. It is time for a global focus on restoring the health of the shared apiary by naturally rearing genetically diverse and resilient lines of bees. Raising Resilient Bees establishes these parameters and provides guidance for new and experienced beekeepers alike to translate these goals into real practice, thereby safeguarding the honey bee from the unknown threats of the future. Authors Eric and Joy McEwen take two decades worth of beekeeping experience, experiments and professional production to deliver groundbreaking methods in queen-rearing, varroa mite management and Natural Nest hive design. Inside, you’ll discover: Revived and adapted heritage Integrated Pest Management techniques How to naturally rear queens and select for resilient, mite-resistant genetic lines without relying on swarming or grafting Key tenets of apicentric beekeeping Advice for establishing a flourishing and sustainable business with beekeeping at the centre How to naturally rear bees with distinctive characteristics suitable to their locale As in large-scale agriculture, the trend toward genetic homogenization is having long-term implications for bees’ capacity to withstand diverse environmental stressors. With expert advice, enthusiasm and easy-to-follow instructions, Raising Resilient Bees delivers important and timely information for every beekeeper to create a healthier future.

Using a number of outstanding examples, this text introduces readers to the immense variety of marine natural compounds, the methodologies to characterize them and the approaches to explore their industrial potential. Care is also taken to discuss the function and ecological context of the compounds.
Carefully produced and easy to read, this book serves students and professionals wishing to familiarize themselves with the field, and is ideally suited as a course book for both industry to academia.

A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people.

It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan?

In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.”

This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger.

Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

- Presents the reasons behind the decisions taken by automated algorithms - Frames eXplainable AI as a bridge between computer scientists and physicians - Emphasizes transparency in data analysis within healthcare - Covers computer vision and deep learning in tandem - Creates space to discuss human-AI relationships in future healthcare

***A Waterstones Best Books of 2022 pick*** A New Scientist Book of the Year Shortlisted for the Wainwright Prize for Conservation Writing 'Fascinating... There is something wondrous in Milman's revelation of our fragile dependency on insect life as well as its beauty and strangeness.' Guardian 'Gripping and especially unnerving.' David Wallace-Wells When is the last time you were stung by a wasp? Or were followed by a cloud of midges? Or saw a butterfly? All these normal occurrences are becoming much rarer. A groundswell of research suggests insect numbers are in serious decline all over the world - in some places by over 90%. The Insect Crisis explores this hidden emergency, arguing that its consequences could even rival climate change. We rely on insect pollination for the bulk of our agriculture, they are a prime food source for birds and fish, and they are a key strut holding up life on Earth, especially our own. In a compelling and entertaining investigation spanning the globe, Milman speaks to the scientists and entomologists studying this catastrophe and asks why these extraordinary creatures are disappearing. Part warning, part celebration of the incredible variety of insects, this book highlights why we need to wake up to this impending environmental disaster.

This pocket-sized photographic guide to the birds of East Africa features 296 birds likely to be spotted in the region.

- Colourful photographs illustrate diagnostic features and plumage differences between male and female or breeding and non-breeding birds.

- Comparative photographs help differentiate between confusing species.

- Important distinguishing characteristics are highlighted in the text.

- Distribution maps and Swahili common names for all species are included.

- Introduction features a labelled bird diagram, habitat map, glossary and useful advice to birdwatchers.

An invaluable guide for visitors to national parks and the many areas in East Africa that are rich in birdlife.

Every city dweller is aware that we are seeing fewer stars at night due to the increasing amount of artificial lighting. But that is just the tip of the iceberg, as far as the loss of natural nocturnal darkness is concerned. Humans and animals worldwide are now suffering from the disrupted rhythm of day and night due to extreme lighting at night. In humans this can lead to illness and increased stress. Hitherto only known to experts, this book is the first to comprehensively treat the entire phenomenon of light pollution. Richly illustrated using unusual images taken from the TV documentation "The Dark Side of Light" by Anja Freyhoff and Thomas Uhlmann, this book is for anyone interested in a harmonious coexistence between humans and nature and a healthy work/life rhythm.

Features Surveys of the systems approach to analysing and understanding multifaceted, complex problems in astrobiology, written by two scientists who also have engineering backgrounds. Systems applications to areas important to astrobiology, such as chemical evolution, prebiotic chemistry, geochemical/geophysical settings conducive to emergence of life, robotic space exploration, and much more. Wide appeal for all readers interested in the origin and occurrence of life in our Solar System and beyond.

Features Introduces the physics of accelerators, lasers, and plasma in tandem with the industrial methodology of inventiveness. Outlines a path from idea to practical implementation of scientific and technological innovation. Contains more than 380 illustrations and numerous end-of-chapter exercises.

Developed from the author's course on advanced mechanics of composite materials, Finite Element Analysis of Composite Materials with Abaqus (R) shows how powerful finite element tools tackle practical problems in the structural analysis of composites. This Second Edition includes two new chapters on "Fatigue" and "Abaqus Programmable Features" as well as a major update of chapter 10 "Delaminations" and significant updates throughout the remaining chapters. Furthermore, it updates all examples, sample code, and problems to Abaqus 2020. Unlike other texts, this one takes theory to a hands-on level by actually solving problems. It explains the concepts involved in the detailed analysis of composites, the mechanics needed to translate those concepts into a mathematical representation of the physical reality, and the solution of the resulting boundary value problems using Abaqus. The reader can follow a process to recreate every example using Abaqus graphical user interface (CAE) by following step-by-step directions in the form of pseudo-code or watching the solutions on YouTube. The first seven chapters provide material ideal for a one-semester course. Along with offering an introduction to finite element analysis for readers without prior knowledge of the finite element method (FEM), these chapters cover the elasticity and strength of laminates, buckling analysis, free edge stresses, computational micromechanics, and viscoelastic models for composites. Emphasizing hereditary phenomena, the book goes on to discuss continuum and discrete damage mechanics as well as delaminations and fatigue. The text also shows readers how to extend the capabilities of Abaqus via "user subroutines" and Python scripting. Aimed at advanced students and professional engineers, this textbook features 62 fully developed examples interspersed with the theory, 82 end-of-chapter exercises, and 50+ separate pieces of Abaqus pseudo-code that illustrate the solution of example problems. The author's website offers the relevant Abaqus and MATLAB model files available for download, enabling readers to easily reproduce the examples and complete the exercises. Video recording of solutions to examples are available on YouTube with multilingual captions.

Recognise birds by their calls with this handy package of CD and accompanying book. These will help identify the sounds made by a range of the most common and widely distributed East African bird species.

- CD features 100 bird calls.

- Each species account features full-colour photographs, a distribution map and information on habitat, behaviour, feeding and nesting preferences, as well as a description of the call or song.

- Common bird names given in English and Swahili.

This is the perfect starting point for those who wish to develop their knowledge of bird calls.

In a brilliant follow-up to his blockbuster "The God Delusion," Dawkins lays out the evidence for evolution.

Originally published in 1995, The Early Writings of Harold W. Clark and Frank Lewis Marsh is the eighth volume in the Creationism in Twentieth Century America series, reissued in 2019. The book is a collection of original writings by the prominent creationist Harold W. Clark, and the biologist, educator and young Earth creationist Frank Lewis Marsh. Although both were significant figures in the anti-evolutionist movement of the early 20th century, unlike other members of the movement, both Marsh and Clarke were trained scientists studying under eminent evolutionists of the time. Both writers struggled to reconcile new scientific understandings of geology, botany and palaeontology, supported by Darwin’s theory of evolution, with their own creationist beliefs in genesis and flood theory. Both scientists as such began to develop their own theories of evolution that remained in line with creationist beliefs. This compact and unique collection includes the writings of Marsh and Clark from this period, featuring some of their well-known works on the subject including ‘Back to Creation’ and ‘Fundamental Biology’. This volume of original sources will be of interest to academics of religion, natural history and historians of the 19th century.