How many fingers do you have? How many toes? This engaging book teaches beginning readers how to count the parts of their bodies. Engage students in reading as they develop their early childhood literacy skills. With TIME For Kids content, this full-color book is aligned to state and national standards, and introduces students to simple informational text features.

Why does the world look to us as it does? Generally speaking, this question has received two types of answers in the cognitive sciences in the past fifty or so years. According to the first, the world looks to us the way it does because we construct it to look as it does. According to the second, the world looks as it does primarily because of how the world is. In The Innocent Eye, Nico Orlandi defends a position that aligns with this second, world-centered tradition, but that also respects some of the insights of constructivism. Orlandi develops an embedded understanding of visual processing according to which, while visual percepts are representational states, the states and structures that precede the production of percepts are not representations. If we study the environmental contingencies in which vision occurs, and we properly distinguish functional states and features of the visual apparatus from representational states and features, we obtain an empirically more plausible, world-centered account. Orlandi shows that this account accords well with models of vision in perceptual psychology - such as Natural Scene Statistics and Bayesian approaches to perception - and outlines some of the ways in which it differs from recent 'enactive' approaches to vision. The main difference is that, although the embedded account recognizes the importance of movement for perception, it does not appeal to action to uncover the richness of visual stimulation. The upshot is that constructive models of vision ascribe mental representations too liberally, ultimately misunderstanding the notion. Orlandi offers a proposal for what mental representations are that, following insights from Brentano, James and a number of contemporary cognitive scientists, appeals to the notions of de-coupleability and absence to distinguish representations from mere tracking states.

Discover the astonishing truth about our aquatic cousins: how they think and what they know, their experiences and unique behaviours, and the many things we have in common. There are 33,000 species of fish on our planet, and that number is constantly increasing. In context, that is more than all the species of mammals, birds, amphibians and reptiles added together, making fish the most numerous vertebrates on our planet. Waters worldwide are teeming with these elusive creatures, but how much do we really know about them? Grouped into thematic chapters - including the Dangerous and Deadly,Unusual Giants and Mini Marvels - in this comprehensive book biologist Doug Mackay-Hope profiles the secret lives of 50 of our most interesting underwater cousins in an insightful and myth-busting study, complete with charming watercolour diagrams and expert insights. Learn about the White-Spotted Pufferfish, whose spines hide a deadly toxin, or the Ocellate River Stingray, who lurks in the rivers of South America and who can kill with just one touch of it's barbed stinger. Meet Bargibant's Pygmy Seahorse, who measures just 2cm in length, as well as the enourmous Whale Shark, which grows to around 13m in length. Be fascinated by the wierd creatures of the deep ocean, such as the Peter's Elephantnosed Fish or the kaleidescopic Picasso's Triggerfish. With a foreword by Jeremy Wade, presenter of River Monsters and Mighty Rivers, and official fish aficionado, this book is a complete compendium of fascinating fish facts, with maps showing where in the globe they can be found, plus facts on how they live, hunt and escape predators. Beautiful illustrations and photographs accompany each entry, as well as interesting facts on how they evolved to adapt tochanging environments, making this book the perfect guide to all things aquatic.

Darwin identified the existence of separate male and female gametes as one of the central mysteries of evolutionary biology. 150 years later, the question of why male gametes exist remains an intriguing puzzle. In this, the first book solely devoted to the evolution of anisogamy, top theorists in the field explore why gamete dimorphism characterizes nearly all plants and animals. Did separate male and female gametes evolve as a result of competition, or does anisogamy instead represent selection for cooperation? If disruptive selection drove the evolution of anisogamy, with male gametes focused on search and fusion, and female gametes provisioning the new zygote, why do some algal species continue to produce gametes of a single size? Does sperm limitation, or escape from infection, better explain the need for extremely small, highly mobile sperm? Written by leaders in the field, this volume offers an authoritative and cutting-edge overview of evolutionary theory.

The Sounds of Science provides a comprehensive account of a large-scale scientific experiment with globally operating seafood corporations headquartered in North America, Europe, and Asia. It describes how scientists worked to identify these, world’s largest seafood companies, and how their disproportionate powers were mobilized in a coalition of companies called SeaBOS (Seafood Business for Ocean Stewardship), aiming to provide global and science-based industry leadership on ocean stewardship. As invoked by the cover art (Flow, 2020) by world-renowned creative director, Kashiwa Sato, the experiment is creating a small wave of change that sits within a larger wave, supporting and generating larger movements towards improved stewardship of the planet. A new direction for the private sector is emerging, and new priorities are flourishing. The book explores how corporations, guided by science, can be part of the solution to the biosphere challenges. Written in collaboration with international experts on sustainability, ocean ecosystems, fisheries policy, and corporations, this book explores the mechanisms leading to the evolution of cooperation, and the barriers to address in order to engage in collaborative learning, corporate change and novel science. It offers tangible advice to scientists on how to work with the private sector for a better, more sustainable world. The Sounds of Science is an important resource for scientists interested in engaging with the private sector. Corporate leaders and policy makers will find this book useful for understanding, collaborating, and working with the planet to reach global sustainability goals.

Climate Change in the Himalayas: Vulnerability and Resilience of Biodiversity and Forest Ecosystems explores and assesses issues affecting species survival in the rich forests of the Himalayan region. This book characterizes current biodiversity statuses, related ecosystem services, and provides new evidence and solutions for climate change effects on Himalayan animals and plants. Written by regional and international experts on climate change, ecosystems and the Himalayas, this book analyzes current species threats, loss of habitats, and carbon effects. It identifies critical areas requiring special attention and provides workable solutions for protection and ecosystem services. As many plant and animal species continue to be classified as extinct due to climate change, urbanization, and failing ecosystems, analyses and techniques in this book offer resolutions for sustaining current risks and curbing future risks. These can also be applied to other biodiverse, at-risk regions of the world.

Computational Intelligence in Protein-Ligand Interaction Analysis presents computational techniques for predicting protein-ligand interactions, recognizing protein interaction sites, and identifying protein drug targets. The book emphasizes novel approaches to protein-ligand interactions, including machine learning and deep learning, presenting a state-of-the-art suite of skills for researchers. The volume represents a resource for scientists, detailing the fundamentals of computational methods, showing how to use computational algorithms to study protein interaction data, and giving scientific explanations for biological data through computational intelligence. Fourteen chapters offer a comprehensive guide to protein interaction data and computational intelligence methods for protein-ligand interactions.

Navigating Non-coding RNA: From Biogenesis to Therapeutic Application provides a concise overview of the field of non-coding RNA (ncRNA). Chapters cover the history of discoveries that have occurred in the area of ncRNA, specific types of ncRNA, housekeeping ncRNAs such as ribosomal RNA, transfer RNA, small nuclear RNA and telomerase RNA, regulatory ncRNAs such as microRNA, small interfering RNA, long non-coding RNA and Y RNA. Biogenesis, structure, function, and regulation of each of these are also explored, in addition to traditional and cutting-edge methods for the identification, functional characterization and structural characterization of ncRNA. The book also focuses on the different types of epitranscriptomic modifications and their involvement in regulating ncRNA structure, stability and intermolecular interactions in addition to the role of ncRNAs in a range of diseases and potential therapeutic applications.

Modern Intervention Tools for Rehabilitation addresses current advancements in rehabilitation to better equip clinicians and researchers in the field. This resource will equip professionals for better patient outcomes and improve future rehabilitation research quality. An interdisciplinary understanding of the rehabilitation field is crucial for improved patient care and outcomes, with relevance to patient care in other disciplines as well. With chapters dedicated to diagnostics, choosing appropriate techniques, managing medical treatment, and proper equipment care, readers will be well-equipped to decide on protocols, increase patient outcomes, and improve quality of life.

Photosynthesis: From Plants to Nanomaterials in the Nanomaterial-Plant Interactions series, summarizes both the foundational mechanisms and latest advances in photosynthesis. With a strong emphasis on artificial photosynthesis, the book also analyzes the role of nanomaterials in energy production. Starting with an introduction to plant photosynthetic systems, chapters discuss the structure of light harvesting systems, energy transfer and membrane protein complexes. The book later describes the role of nanoparticles in photosynthesis, including agricultural applications, advances in nanobionics, and the impact of engineered nanomaterials. This book is an essential read for researchers and students interested in photosynthesis, bionanotechnology and nanomaterials.

The latest edition of this classic guide details how to understand and resolve a broad array of human-wildlife conflicts. This new edition of Human-Wildlife Conflict Management updates our understanding of the human dimensions, as well as biological and ecological concepts, underlying human-wildlife conflicts. While it provides wildlife professionals and students with the knowledge and adaptive management strategies to resolve such conflicts, it uniquely explores negative interactions with a wide range of wildlife taxa beyond those typically covered in traditional wildlife damage management, including invasive plants, invertebrates, and fish. Designed to help students and natural resource practitioners gain a deeper understanding of how to successfully avoid and resolve conflict between humans and wildlife, it is informed by author Russell F. Reidinger's decades of teaching students and professionals how to anticipate and manage human-wildlife conflicts, as well as his experience leading a national research program devoted to this work. The book covers important human-wildlife topics such as: * individual-, population-, and ecosystem-level effects * survey techniques * management methods * human dimensions * economic issues * legal and political aspects * damage management strategies Featuring explanations of important terminology and pertinent biological and ecological concepts, Reidinger also shares the latest research, provides a plethora of real-world examples, and includes suggestions for additional resources.

Fibroblast Growth Factors, Second Edition systematically introduces readers to FGF in the fields of injury repair and regeneration, endocrinology and metabolism, structure and modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor, engineering and new drug development. Fibroblast growth factors (FGFs) are secreted protein ligands that act in a paracrine or endocrine fashion to carry out their pleiotropic functions in development, tissue homeostasis and metabolism. This book covers the work from Li’s team from 2013 to 2018 and will be a primer for scientists, particularly young students entering the FGFs field with an eye on basic research and application.

Ticks: Biology, Ecology and Diseases provides a detailed overview of the fascinating world of tick biology and ecology. This book discusses disease transmission to humans and livestock, assesses the impact of human behavior and climate change on tick biology, and details how this will affect future disease transmission. Written by an expert on ticks and their transmitted diseases, this book explores the unique biology of ticks and how it influences the transmission of some of the most devastating diseases. In a series of detailed chapters, the book provides up-to-date information on the interrelationship between ticks and the vertebrates they feed on. In addition, the book covers information on recent scientific discoveries surrounding ticks, along with reviews on control methods and disease transmission. Other sections cover the recent emergence of tick-borne pathogens, making this book an ideal source for interested scientists, clinicians, veterinarians and experts in the field of tick biology.

Neurostimulation for Epilepsy: Advances, Applications and Opportunities comprehensively reviews the diverse array of neurostimulation technologies currently in use and development for the treatment of epilepsy. The book covers basic research on mechanisms of neurostimulation, technical features of various FDA-approved and investigational devices for neurostimulation, clinical applications and programming considerations of these devices, and emerging insights and research based on data derived from these devices. It provides a contemporary assessment of neurostimulation in epilepsy, one that reveals recent progress in clinical applications and outcomes, fundamental questions that remain unanswered in the field, and future directions and considerations in developing next-generation devices.

Laboratory Methods in Microbiology and Molecular Biology: Methods in Molecular Microbiology is a unique, informative and multidisciplinary work that is not only confined to one discipline. It provides various procedures in diverse disciplines from microbiology to genetics, molecular biology and biochemistry. Here, the principles and facts underlying practical applications of bacteria and fungi which have prospects in various technologies are listed. It is composed of 15 chapters broadly covering basic concepts in microbiology, including soil microbiology, food microbiology, microbial genetics, serology and the use of basic bioinformatics tools. Each chapter contains a set of experiments with an introduction, principle, reagents and buffers used, brief methodology, conclusions and inferences, and a list of 20-40 references. A brief summary/abstract is also included. The book will facilitate students, teachers and researchers to monitor the precision and accuracy of their qualitative and quantitative methods practically.

Genetic Engineering and Genome Editing for Zinc Biofortification of Rice provides the first single-volume, comprehensive resource on genetic engineering approaches, including novel genome editing techniques, that are carried out in rice, a staple crop for much of the world's population. Dietary zinc deficiency can lead to negative health outcomes, including increased risk of stunting, respiratory diseases, diarrhea, mortality during childhood, and preterm births in pregnancy. By providing a complete view of the need for zinc biofortification in rice, sections in this book discuss state-of-the-art scientific advances, and then go further, placing them in their proper scientific, regulatory and socioeconomic contexts. While zinc biofortification can be achieved through conventional breeding, genetic engineering and agronomic practices, this is the first reference to bring all the latest insights and understanding to a comprehensive resource that is based on real-world experience and targeted applications.

The Role of Growth Regulators and Phytohormones in Overcoming Environmental Stress is a comprehensive resource on all major PGRs. These include auxins, cytokinins, jasmonates, polyammines, plant growth promoting rhizobacteria (PGPR), and more. In the last two decades, researchers have explored a lot about the roles of plant growth regulators (PGRs) in boosting the resistance of plants under stress conditions. These PGRs acts as stimulators for various physiological processes by regulating key cell signaling pathways. This title is an essential read for any scientist wanting to understand the latest advances in combatting abiotic stresses using plant growth regulators. In the present era, plants are facing a lot of challenges during their lifecycle, including growth declines due to abiotic stress. The main abiotic stresses threatening plants are water scarcity, salinity, extreme temperatures, heavy metals and pesticides. These stresses directly or indirectly cause toxicity to plants, causing hindrance to their growth and development, and ultimately reduce plant productivity.

Current Trends and Future Developments on (Bio-) Membranes: Recent Achievements for Ion-Exchange Membranes focuses on introducing and analyzing ion-exchange membranes performance and overviewing recent achievements in the structural development of ion-exchange membranes in various applications. Hence, this book is a key reference text for R&D managers in who are interested in the development of ion-exchange membrane technologies as well as academic researchers and postgraduate students working in the wider area of strategic treatments, separation and purification processes.

Two distinguished scientists encouraged Warwick Collins in writing his revolutionary theory of evolution. Professor Freeman Dyson, one of the world's leading theoretical physicists, wrote, "I like your theory, and think it has a good chance of being right."He added, "Darwin would have liked your theory." Professor Donald Braben, a nuclear physicist who directed a series of wide-ranging research programs at BP, responded, "Hierarchically speaking, variation is of greater significance than selection. I agree, therefore, that if silent gene theory were proved correct, it would be the more complete theory, as Einstein's is compared with Newton's."Charles Darwin wrote in The Origin of Species that ..". unless profitable variations do occur, natural selection can do nothing." As Darwin recognized, natural selection, far from increasing variation within species, reduces variation constantly in favor of an optimum type. What then is the true source of variation in evolutionary systems? It is a question which has obsessed Warwick Collins, a novelist who had studied biology at university, for much of his adult life.He proposed in March 2000 that the required degree of variation could be achieved if large numbers of inert or silent genes existed within the genome. Such genes, because they do not code for physical characteristics, could freely mutate over time without deleteriously affecting the host organism. At a later stage they could be switched on, by largely random processes, and generate exotic new variants. Remarkably, his description of silent genes was found to correspond precisely with the so-called junk genes. These are found in all species, forming the great majority of genes in multicellular species and rising to 98.5% of the genome in humans. Until then their function had proved mysterious. In addition, Collins's theory predicted a number of features of the silent or junk genes which have since been increasingly verified by recent research: for example, that they could become active and begin to code, and that they influenced other genes.It is now widely accepted that, just as Collins predicted, the vast majority of significant mutation in the genomes of complex species arises from the silent genes. But Collins's powerful and ambitious theory moves well beyond the molecular realm. He argues that while natural selection is a major force in evolution, it is primarily negative and entropic. Instead, the great driver of complex evolution is the range of variation created by the silent genes. As Professor Donald Braben writes in his illuminating foreword, "Collins is proposing a general evolutionary theory which, if it continues to be supported by the data, may in due course come to rival Darwin's theory that evolution is driven by natural selection."

Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies. In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering. Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence.

The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation has played in adaptive evolution, as well as in developmental biology and susceptibility to disease. Here, Moyra Smith, a celebrated researcher in the field, sheds light on common themes in gene regulation across evolutionary timelines, illuminating new areas of focus and pathways for future research. Early chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time and in response to environmental and local conditions, and the role of epigenetics in adaptive evolution, with later chapters considering the role of adaptive gene regulation in healthy processes and developmental biology, as well as in disease biology. Throughout the book, a comparative approach is adopted across organisms, to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.

The Impact of Nanoparticles on Agriculture and Soil, part of the Nanomaterials-Plant Interaction series, contributes the most recent insights into understanding the cellular interactions of nanoparticles in an agricultural setting, focusing on current applications and means of evaluating future prospects. In order to ensure and improve the biosafety of nanoparticles, it is a primary concern to understand cellular bioprocess like nanomaterial's cellular uptake and their influence on cellular structural, functional and genetic components. This book addresses these and other important aspects in detail along with showcasing their applications in the area of agriculture. With an international team of authors, and experienced editors, this book will be valuable to those working to understand and advance nanoscience to benefit agricultural production and human and environmental welfare. In-depth knowledge of these bioprocess will enable researchers to engineer nanomaterials for enhanced biosafety.

This authoritative volume provides a comprehensive guide to the 282 species of woody plants found in Kentucky, Illinois, Indiana, Ohio, Pennsylvania, West Virginia, Virginia, Tennessee, and Eastern Missouri. Illustrated with more than 1,150 photographs, this book shows not only leaves and bark, but also buds, flowers, and fruits to enable you to recognize trees at any season. Complete with an identification guide that really works, this beautiful book will be valuable to both specialist and amateur.

Bioengineered Nanomaterials for Wound Healing and Infection Control is a key reference for those working in the fields of materials science, pharmacy, nanotechnology, biomedical engineering and microbiology. Bioengineered nanomaterials have unique physicochemical properties which promote accelerated wound healing and treatment of infections. The biosynthesis of these nanomaterials also offers a clean, safe and renewable alternative to traditional nanomaterials, helping reduce environmental impact alongside antibacterial resistance.

Phytohormones and Stress Responsive Secondary Metabolites provides a deep dive into the signaling pathways associated with phytohormones and phytometabolites. With a strong focus on plant stress responses and DNA technology, the book highlights plant biotechnology and metabolic engineering principles. Biotechnology, by using DNA editing technologies, allows the expression of plant genes into other plant species with desirable modulation on plant behavior. Beginning with an overview of phytohormone signaling, growth and abiotic and biotic stresses, subsequent chapters explore DNA modification strategies, epigenetic and epigenomic regulation, and miRNA regulation. This book will be an essential resource for students, researchers and agriculturalists interested in plant physiology, plant genetics and plant biotechnology.