Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikov's Rule are addressed. The book introduces Walden's original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion. With its unique perspective, focus, and comprehensive coverage, this book belongs on the shelf of every organic chemist.

Wastewaters generated from food production and agricultural activities are a source of environmental pollution due to their huge amount of nutrients, organic carbon, nitrogenous organics, inorganics, suspended and dissolved solids, and high biochemical and chemical oxygen demands. Advanced Technologies in Wastewater Treatment: Food Processing Industry provides an update on emerging technologies including oxidative and anaerobic processes (flotation, coagulation, sedimentation, filtration, adsorption, primary settling, secondary activated sludge, anaerobic digestion), ion exchange, membrane-based operations, adsorption/bio-sorption and advanced biological treatment to provide safe and clean water as well as to recover primary resources from food processing wastewaters. In addition, the integration of these technologies will be also considered in the logic of the process intensification strategy. Innovative and affordable solutions are proposed in the field of fruit and vegetable processing industry, fishing industry, meat and poultry industry, dairy production, oil and fat processing.

Evolutionary theory is all the rage, but how accurate is the information we are being fed? Jim Alexander casts a critical eye over the new popular concensus, addressing important issues in one of the key debates in modern society.

Role of TRPV4 Channels in Different Organ Systems, Volume 89, the latest release in the Current Topics in Membranes series, provides an in-depth description of the role of TRPV4 ion channels in different organ systems under healthy and disease conditions. Research over the last two decades shows crucial physiological and pathological roles for TRPV4 channels. In this volume, we present chapters focusing on TRPV4 channels in the vasculature, lungs, heart, kidney, bladder, skin, musculoskeletal system, eye, and immune cells. Understanding the behavior of TRPV4 channels in various organ systems will provide a big picture on their physiological roles and therapeutic targeting.

Fifty Years of Peeling Away the Lead Paint Problem: Saving Our Children's Future with Healthy Housing documents the history of childhood lead poisoning from paint between 1970 and 2022. Tracing the failure of the medical model (treatment after exposure) that marked the 1970s and 1980s and its replacement with a prevention housing-focused effort, the book documents the changes in health, housing and environmental science and policy. It is the first book to examine how the lead poisoning law in the U.S. was passed in 1992 and later implemented, with implications for the future, in particular, the emergence of a healthy housing movement. The book describes the roles played by Congress, various administrations, agencies, local governments, the private sector, researchers, and a popular citizen's movement, especially parents. The role of the courts is discussed, including a controversial lead paint case on research ethics in Baltimore through an environmental justice lens. This book is the first to examine another recent case in California, where ten local jurisdictions established a precedent by successfully suing the lead paint industry to help pay for abatement.

Advances in Genetics, Volume 109 in this ongoing series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Epigenetic regulation of angiogenesis in tumor progression, RecBCD and Chi hotspots as determinants of self vs. non-self: A re-evaluation, Horizontal gene transfer to plants from Agrobacterium and related bacterial species, and more.

Collective Memory, Volume 274 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of interesting topics, including Deriving testable hypotheses through an analogy between individual and collective memory and updated information on Collective future thinking: Current research and future directions.

Advances in Microbial Physiology, Volume 81 highlights new advances in the field with this new release presenting interesting chapters written by an international board of authors. Updates in this release include sections on Antibiotic tolerance, Lanthanides in bacterial proteins, Bacterial toxins and host-microbe interactions, and Nitric oxide.

MRNA-Based Therapeutics, Volume 372 in the International Review of Cell and Molecular Biology series, covers topics surrounding the effect of different metabolic situations, their contribution to metabolic modulation, and their impact on tumor growth. Specific chapters in this release include New era of nucleic acid therapies: Clinical applications and perspectives, Messenger RNA as personalized therapy: time of truth for rare metabolic disease, Applications of Self-Replicating RNA, mRNA therapy in PKU, Advances in gene-editing technologies, mRNA delivery technologies: towards clinical translation, Advances in mRNA vaccines, and more.

Industrial wastewater contains a large variety of compounds, such as hazardous organic pollutants, heavy metals, salts and nutrients, which makes its treatment challenging. On the other hand, the sewage treatment with existing technologies is not cost-effective due to high energy demand and contributes to greenhouse gas emission. Thus, the use of conventional water treatment methods is neither sustainable nor always effective. In this sense, BESs has emerged as a promising technology to treat complex industrial wastewater with a sustainable manner. Development in Wastewater Treatment Research and Processes: Bioelectrochemical Systems for Wastewater Management analyses and discusses the potential of microbial and electrochemical based hybrid processes for the treatment of complex industrial wastewater along with the recovery of valuable compounds and water reutilization. The most significant advantages of BES are high effectiveness, low toxicity, gentle operation conditions, environmentally friendly treatment without sludge accumulation and energy conservation. Bioelectrochemical systems (BES) are emerging as an exciting platform to convert chemical energy of organic wastes into electricity or hydrogen or value-added chemical commodities. In addition, recent and future trends in BES are highlighted.

The Immunological Synapse, Part A, Volume 173 in the Methods in Cell Biology series provides state-of-the-art methods for the study of the immunological synapse. Sections cover Imaging polarized granule release at the cytotoxic T cell immunological synapse using TIRF microscopy: control by polarity regulators, Analysis of centrosomal area actin reorganization and centrosome polarization upon lymphocyte activation at the immunological synapse, P815-based redirected degranulation assay to study human NK cell effector functions, Cytotoxic and Chemotactic Dynamics of Natural Killer Cells Quantified by Live-cell Imaging, Quantification of interaction frequency between antigen-presenting cells and T cells by conjugation assay, and more. Other chapters focus on the Study of the Effects of NK-Tumor Cell Interaction by Proteomic Analysis and Imaging, Quantification of lymphocytic choriomeningitis virus specific T cells and LCMV viral titers, Quantification of lymphocytic choriomeningitis virus specific T cells and LCMV viral titers, An in vitro model to monitor natural killer cell effector functions against primary breast cancer, and Standardized Protocol for the Evaluation of Chimeric Antigen Receptor (CAR)-modified Cell Immunological Synapse Quality using the Glass-supported Planar L.

DNA Damage and Double Strand Breaks, Volume 51 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters that provide an update on female and male genital schistosomiasis and a call to integrate efforts to escalate diagnosis, treatment and awareness in endemic and non-endemic settings, vertebrates as uninfected disseminators of helminth eggs and larvae, and combatting anthelmintic resistance in ruminants.

Athlete Mental Health and Performance Optimization: The Optimum Performance Program for Sports (TOPPS)introduces TOPPS, which provides structured protocols to assist with recruitment, engagement, screening, assessment and performance optimization. The book presents step-by-step instructional guidelines, real-world case examples, screening and assessment questionnaires, scoring instructions, intervention handouts and worksheets that complement intervention. TOPPS has demonstrated significantly improved relationships with teammates and coaches, decreased substance use and psychiatric symptoms, and decreased factors interfering with sport performance. These results have been sustained in follow-up and has been shown to have improved outcomes regardless of mental health diagnostic severity. The Book's first three chapters introduce performance optimization orientation, theories and evidence supporting TOPPS, general assessment and intervention approaches, psychometrically-validated measures and strategies used to address culture, methods of establishing a culture of optimization and requisite infrastructure within the respective system, and therapeutic style, techniques and implementation strategies. Remaining chapters show how to implement TOPPS.

William LaFleur (1936-2010), an eminent scholar of Japanese studies, left behind a substantial number of influential publications, as well as several unpublished works. The most significant of these examines debates concerning the practice of organ transplantation in Japan and the United States, and is published here for the first time. This provocative book challenges the North American medical and bioethical consensus that considers the transplantation of organs from brain dead donors as an unalloyed good. It joins a growing chorus of voices that question the assumption that brain death can be equated facilely with death. It provides a deep investigation of debates in Japan, introducing numerous Japanese bioethicists whose work has never been treated in English. It also provides a history of similar debates in the United States, problematizing the commonly held view that the American public was quick and eager to accept the redefinition of death. A work of intellectual and social history, this book also directly engages with questions that grow ever more relevant as the technologies we develop to extend life continue to advance. While the benefits of these technologies are obvious, their costs are often more difficult to articulate. Calling attention to the risks associated with our current biotech trajectory, LaFleur stakes out a highly original position that does not fall neatly onto either side of contemporary US ideological divides.

Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.

Development in Wastewater Treatment Research and Processes: Microbial Ecology, Diversity and Functions of Ammonia Oxidizing Bacteria covers up-to-date research on ammonia oxidizing bacteria and their application for the removal of ammonia nitrogen from wastewater treatment plants (WWTPs), discussing remaining gaps in their biology and functions. In this sense, this book features the application of the newly developed omics tools in order to develop less energy intensive and cost-effective biological processes for nitrogen removal from WWTPs. This makes this book an essential and unique book for advanced students, research scientists, environmental agencies and industries involved in wastewater treatment.

Advances in Genetics serial, Volume 110 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, all written by an international board of authors.

Treatment and Reuse of Sewage Sludge: An Innovative Approach for Wastewater Treatment: Developments in Waste Water Treatment Research and Processes series, focuses on the exploitation of various treatment technologies and their use to treat sewage sludge to detoxify/stabilize toxic and hazardous contaminants and restore contaminated sites, which lacks in a more comprehensive manner in currently existing titles on similar topics. The book includes current beneficial sludge utilization practices such as land application, energy recovery, use as an alternative fuel source, use as a construction material and resource recovery from sewage sludge using emerging technologies. In addition, the book includes numerous current and advanced sewage sludge treatment and reuse technologies and associated microbes to effectively treat and manage hazardous industrial wastes/or wastewater pollutants for environmental safety, sustainability and public health protection. The book is a reference for all researchers working in the field of environmental engineering, bioengineering, waste management, and related fields.

Integrated Methods in Protein Biochemistry: Part A, Volume 677, the latest release in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics such as DNA and protein engineering to create protein bioswitches with new functions, Interaction and cross-talk of prelamin A with integral membrane zinc metalloproteases, An experimental protocol to study lipid transfer proteins, Synthesis of small heat shock proteins, Druggable p-p interacting sites for Co-chaperone DNAJA1 and its partner proteins, An experimental protocol for glycoconjugate analysis, Methods for proximity-based biotinylation combined with Mass Spectrometry, and more. Additional chapters cover Synthetic antibody fragments as conformational sensors of protein activation and trafficking, Expression, purification, functional analysis and crystallization of Rag GTPase, Purification of bacterial transcription elongation complexes by photoreversible immobilization, Inhibition of c-Myc-MAX heterodimerization, Fluorogenic RNA aptamers to probe transcription by multi-subunit RNA polymerases, and much more.

Carotenoids: Carotenoid and Apocarotenoid Biosynthesis, Metabolic Engineering and Synthetic Biology, Volume 671, the latest release in the Methods of Enzymology series highlights new advances in the field with chapters on Metabolomics-based analysis of carotenoids and related metabolites in various species via quantitative trait loci and genome wide association mapping approaches, Using bacteria for functional analysis of genes encoding carotenoid biosynthetic enzymes, Rice Callus as a High Throughput Platform for Synthetic Biology and Metabolic Engineering of Carotenoids, Transient expression in Nicotiana benthamiana: A simple platform to investigate genes encoding carotenoid biosynthesis enzymes from diverse algal lineages, and much more. Additional chapters in this new release cover Protein-protein interaction techniques to investigate post-translational regulation of carotenogenesis, The isolation of sub-chromoplast structures from tomato and capsicum fruit, Carrot protoplasts as a suitable method for protein subcellular localization, High throughput production and characterization of carotenoid enzymes for structural and functional studies, Production and structural characterization of the cytochrome P450 enzymes in carotene ring hydroxylation, and more.

Circadian and Visual Neuroscience, Volume 273 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on topics including Optical set-ups, Psychophysics of Luminance and Color Vision, Psychophysics of non-visual photoreception PRC/IRC/DRC/Spectral Sensitivity, Circadian and visual photometry, Modelling (retina), Modelling (circadian), Techniques for examining vision at the cellular level, Advanced techniques for characterizing the world hyperspectrally, Circadian physiology in mice: Melanopsin, Circadian physiology in mice: Color and cones, Translational aspects of animal studies, Retinal clocks, Primate non-visual physiology, Light and mood in animal models, and much more.

Protect crop yields and strengthen ecosystems with this essential guide Research into weed management is an increasingly critical component of both environmental stewardship and food production. The potential cost of weed propagation can be measured in crop yield reductions, under-nourished populations, stymied economies, and more. The propagation of herbicide-resistant weed populations means that purely chemical weed management is no longer viable; food production can now be secured only with an ecological approach to weed control. Ecologically-Based Weed Management details such approaches and their potential to manage weeds across a range of agricultural and environmental contexts. It emphasizes the deployment of ecological principles to prevent weed infestations, reduce crop losses, and strengthen ecosystems. In a time when growing population and changing climates are placing enormous pressure on global food production, this approach to weed management has never been more vital. Ecologically-Based Weed Management readers will also find: A global team of expert contributors to a multidisciplinary approach Detailed discussion of topics like herbicide limitation, integrated weed management, and more Insights pertinent to agriculture, academia, government, industry, and more Ecologically-Based Weed Management is ideal for researchers in agriculture chemistry, weed science, agronomy, ecology, and related fields, as well as for regulators and advanced students.

Environmental Noise Pollution, Second Edition, addresses the key debates surrounding environmental noise pollution, its modelling and mitigation using examples from across the globe. Environmental noise pollution is now an established concern in environmental and public policy and is considered one of the most important environmental stressors affecting public health throughout the world. Thoroughly revised, this new edition includes updated global case studies as well as new chapters on 'soundscapes and noise mapping' and 'environmental noise and technology'. This book examines environmental noise pollution, its health implications, noise modelling, the role of strategic noise mapping for problem assessment, major sources of environmental noise pollution, noise mitigation approaches, and related procedural and policy implications. Drawing on the authors' considerable research expertise in the area, the book is a fully updated resource on this major environmental stressor that crosses disciplinary, policy and national boundaries.

Occupational Neurotoxicology, Volume Seven covers neurotoxicants and exposures to a variety of hazards in the workplace and how they can affect nervous functions in different ways. Metals and organic compounds, both at high level acute exposure and long-term low-level exposure can affect motor functions, cognition, behavior and neurosensory functions. Sections cover Oil leakage in aircraft, aerotoxic syndrome, Organic solvents, WTC neurotoxicities, Environmental intolerance, Pesticides, Carbon monoxide, Mercury Neurotoxicity in Gold Miners, and the Current evolution of neurobehavioral methods.