Handbook of Gastrointestinal Motility and Disorders of Gut and Brain Interactions, Second Edition fills the void in GI literature for a short and concise go-to book for GI motility and gut and brain interactions disorders. This exceptionally illustrated reference contains all the information needed for a quick reference of GI motility and disorders of the gut and brain interactions, as well as adolescent and pediatric disorders and disorders which affect the entire GI system, each systematically arranged by disorder and gut anatomy for easy reference. Each chapter also includes extensive color pictures and illustrations of each test involved as well as descriptions of how to perform and interpret the motility tests that are incorporated into patient care decisions. The current advances in the field have led the way for new updates to existing content as well as a new section for the book dedicated to systemic disorders and special topics including neurology of the gut, cannabis and the gut, eating disorders, pediatric and adolescent disorders, nutritional therapies, and psychological evaluation and treatment. This is the perfect reference for those who encounter the common problems of dysphagia, heartburn, nausea, vomiting, abdominal pain, irritable bowel syndrome, constipation, and fecal incontinence in daily practice including practicing physicians, gastroenterologists, motility laboratory personnel, surgeons, and internists.

A completely up-to-date introduction to the most common group of bees in Britain. Bees, for most people, mean honey or bumble bees, but in fact these social species make up only a small proportion of the species that live in Britain. Open your eyes to the so-called ‘solitary’ bees, and discover a wonderfully diverse population – miners, leafcutters, carpenters and masons – many of which can be found in your own back garden. Solitary bees come in a variety of colours and sizes, with some as large as bumblebees and some only a few millimetres long, and many are key pollinators for our crops and wildflowers. This comprehensive book will tell the story of how these bees live, reproduce and thrive: discover the numerous strategies used by male bees to find females and persuade them to mate; follow the females as they build their nests – or in the case of ‘cuckoo’ species, sneak into the nests of their neighbours – and watch as the new generation appears. Explore the interactions between flowering plants and their bee visitors, asking what the plants get from the relationship, as well as how the bees select the plants they visit, and the ingenuity required to extract pollen, nectar and other rewards. Finally, learn places where bees flourish and what can be done to encourage them and ensure they continue to pollinate our flowers and crops. Drawing on all the latest research as well as the authors’ own observations in the field, this timely New Naturalist gives a wonderful insight into the complicated lives of solitary bees, and the complexity of the behaviour and ecology of this remarkable group of insects.

Coenzyme B12 Enzymes, Part B, Volume 169 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on Structural characterization of cobalamin-dependent radical SAM methylases, Purification and characterization of sequential cobalamin-dependent radical SAM methylases ThnK and TokK in -lactam antibiotic biosynthesis, Characterization of the cobalamin-dependent radical S-adenosyl-L-methionine enzyme C-methyltransferase Fom3 in fosfomycin biosynthesis, Studies of OxsB and GenK, two B12-dependent radical SAM enzymes involved in natural product biosynthesis, Purification and structural elucidation of the cobalamin-dependent radical SAM enzyme OxsB, and more. Other chapters discuss Methods for studying the mechanisms of B12 enzymes, Computational investigations of B12 dependent enzymatic reactions, Using kinetic isotope effects to probe the mechanisms of adenosylcobalamin-dependent enzymes, Steady-state and pre-steady state kinetic analysis of ornithine 4,5-aminomutase, and more.

Cyanobacteria are ancient, primordial oxygenic phototrophs, and probably the progenitor of oxygen-evolving photosynthesis. They are a prolific source of natural products and metabolites and vitally important for environmental biology and biotechnology. Cyanobacterial Physiology presents foundational knowledge alongside the most recent advances in cyanobacterial biology. The title examines the challenges of industrial application through an understanding of the basic molecular machinery of cyanobacteria. Sixteen chapters are organized into three sections. The first part covers basic cyanobacterial biology, emphasizing environmental biology such as photosynthesis, nitrogen fixation, circadian rhythm, and programmed cell death. The second part includes the chapters that discuss cyanobacterial extremophiles, adaptations, secondary metabolites, osmoprotectants, and toxins. The third part covers aspects of cyanobacterial application that are based on environmental biology. Leading scientists contribute chapters on cyanobacteria. Cyanobacterial Physiology presents a comprehensive and vibrant solution for researchers and engineers in biotechnology interested in cyanobacteria and their applications. Topics include the cyanobacterial cell and fundamental physiological processes; the biotechnological potential of cyanobacteria with their versatile metabolism; and advanced applications of cyanobacterial products. At each stage the book is informed by basic and applied research.

Plant Nematode Biopesticides presents the most current knowledge on various categories of biopesticides used in the management of nematode pests of crops or those that have significant potential as biological control agents. This book presents an exploratory and investigatory compilation and explanation of the actions and potentials of predatory nematodes, microbial agents, plant and other organic products, nanobiopesticides, and predatory invertebrates as biopesticides of nematode pests of agricultural crops. It is of unique importance and value as the only currently available single-volume resource focusing on plant parasitic nematodes as the pests and biopesticides. In addition, the book addresses common reservations in using biopesticides, either alone or in integrated pest management programs, providing advanced insights on various biopesticidal agents and products. Biopesticides may be microbial (nematodes, bacteria, fungi, virus, herbs etc.), plant-incorporated protectants (PIPs), plant products (citronella oil, neem oil, capsaicin, pyrethrin etc.), synthetic biochemical molecules, pheromones, semio-chemicals, plant extracts, or nanobiopesticides.

Neurosurgical Management of Psychiatric Disorders, Part B, Volume 267 in the Progress in Brain Research serial highlights new advances in the field with this new volume presenting interesting chapters on topics such as the Neurosurgical Management of Tourette Syndrome, Stereotactic Surgeries for Opioid Addiction: Patient Selection and Results, Psychiatric Disorders as Indication for Surgical Management of Drug-Resistant Temporal Epilepsy, Surgery of Autism: Is it Possible?, Psychogenic Pain: Diagnosis and Management, Stereotactic Cingulotomy and Capsulotomy for Obsessive-Compulsive Disorders: Indications and Comparative Results, and much more.

Tremors, Volume 163 in the International Review in Neurobiology serial highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

The marine environment, in addition to a not insignificant background of "natural" radioactivity, has continued to receive inputs of radionuclides directly or indirectly through atomic fallout, discharges from the nuclear industry or from nuclear accidents. After their introduction, the fate of these radionuclides is complex with modifications of physicochemical forms, dispersion in marine water masses and adsorption onto sedimentary particles. Marine organisms then bioaccumulate these radionuclides to a greater or lesser extent, dispersing them via their burrowing activities, horizontal and vertical migrations or through food webs. All of these phenomena lead to very variable radioactive contamination, depending on location and the nature of the marine environments concerned, and consequently, to very different doses of irradiation to marine organisms. The harmful effects of ionizing radiation on living marine organisms are felt at varying levels of biological organization from the molecule to the ecosystem, passing through the cell, the organ, the individual and the population. In the end, the radioactive risk for marine organisms can decline according to several situations, which can be normal, programmed or accidental.

Cell Signaling Pathways in Development, Volume 149 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Ephrin signaling, Cell signaling to the extracellular matrix, Signaling by TGF-b superfamily members, Hedgehog signaling, Parallels in signaling during development and regeneration, Hippo signaling, Wnt/PCP signaling, Signaling oscillations in presomitic mesoderm, FGFs/RTKs subcellular signaling compartments, and Signaling dynamics.

Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.

One, No One, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part B, Volume 369 provides in-depth reviews on the last progresses on the role of macrophages in health and diseases, with a special focus on the role of macrophages during development. New chapters cover The role of salivary gland macrophages in infection, disease and repair, Reprogramming or replacing brain macrophages to treat neurodegenerative disease, Targeting macrophages for cancer immunotherapy, Heart Macrophages at steady-state and disease: simple bystanders or active players?, Macrophages in the liver, and Developmental programming of macrophages.

B12 Enzyme, Volume 667 in the Methods in Enzymology serial, highlights new advances in the field with this new volume presenting timely, interesting chapters, including Part I: B12 Biosynthesis and B12 Chaperones, Probing the preference and regioselectivity of lower ligand activation and its role in cobamide diversity, Biosynthesis of corrinoids, The human B12 trafficking chaperones: CblC, CblD and ATR, A method for the efficient adenosylation of corrinoids, Production, purification and liposome reconstitution of cobamide synthase, Extraction and Purification of Cobamides from Bacterial Cultures, Part II: The many faces of B12-dependent enzyme reactions, Methylcobalamin-dependent methionine synthase, and much more.

Advances in Agronomy, Volume 174, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field. Each chapter is written by an international board of authors.

Large Animals as Models for Human Diseases, Volume 189 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of important topics, including Sheep as a model for neuroendocrinology research, Relevance of dog as a model for urologic diseases, Relevance of lactocrine hypothesis to human maternal programming of development, Comparative aspects of embryo implantation, Pig as an animal model for obesity, Canine models of cancer, Bovine model for human ovarian diseases, Mutations in G protein-coupled receptors in large animals: Modeling human diseases, and more.

Biomolecular Interactions: Part A, Volume 169, the latest release in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Emerging Mechanisms of Targeted Protein Degradation by Molecular Glues, Design and use of programmable DNA Hydrogels, Oligomerization of membrane receptors: Approaches to measure in live cells, Interactions of alpha-synuclein with biomolecules, Gel-electrophoresis based method for biomolecular interaction, Recombinant centrosome expression in bacterial system, Reconstituting CCL5-CCR5 complex for structural and mechanistic analysis, Protein engineering and design in ion channel receptors, and much more.