This highly engaging exploration of the concept of evolution lays out the history of life on earth-what we know and how we know it. Ever since Charles Darwin revealed his landmark ideas about evolution in 1859, new findings have confirmed, expanded, and refined his concepts. This ALSC Notable children's book brings together the pillars of evidence that support our understanding of evolution. In addition to stunning illustrations, more than fifty photographs capture natural marvels, including awe-inspiring fossils, life forms, and geological wonders. The result is a full and clear account of the monumental evidence supporting the modern view of evolution.

This 21st Century Nanoscience Handbook will be the most comprehensive, up-to-date large reference work for the field of nanoscience. Handbook of Nanophysics by the same editor published in the fall of 2010 and was embraced as the first comprehensive reference to consider both fundamental and applied aspects of nanophysics. This follow-up project has been conceived as a necessary expansion and full update that considers the significant advances made in the field since 2010. It goes well beyond the physics as warranted by recent developments in the field. This eighth volume in a ten-volume set covers nanopharmaceuticals, nanomedicine, and food nanoscience. Key Features: Provides the most comprehensive, up-to-date large reference work for the field. Chapters written by international experts in the field. Emphasises presentation and real results and applications. This handbook distinguishes itself from other works by its breadth of coverage, readability and timely topics. The intended readership is very broad, from students and instructors to engineers, physicists, chemists, biologists, biomedical researchers, industry professionals, governmental scientists, and others whose work is impacted by nanotechnology. It will be an indispensable resource in academic, government, and industry libraries worldwide. The fields impacted by nanophysics extend from materials science and engineering to biotechnology, biomedical engineering, medicine, electrical engineering, pharmaceutical science, computer technology, aerospace engineering, mechanical engineering, food science, and beyond.

Purposefully designed as a resource for practicing and student toxicologists, Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition equips you for the regular statistical analysis of experimental data. Starting with the assumption of basic mathematical skills and knowledge, the author supplies a complete and systematic yet practical introduction to the statistical methodologists available for, and used in, the discipline. For every technique presented, a worked example from toxicology is also presented. See what's new in the Fourth Edition: -The first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies -Coverage of Bayesian analysis and data analysis in pharmacology and toxicology -Almost 200 problems with solutions -Discussion of analysis of receptor binding assays, safety pharmacology assays and other standard types conducted in pharmacology -A new chapter explaining the basics of Good Laboratory Practices (GLPs) -For those with computer skills, this edition has been enhanced with the addition of basic SAS Written specifically for toxicologists and pharmacologists, the author draws on more than 30 years of experience to provide understanding of the philosophical underpinnings for the overall structure of analysis. The book's organization fosters the ordered development of skills and yet still facilitates ease of access to information as needed. This Fourth Edition gives you the tools necessary to perform rigorous and critical analysis of experimental data and the insight to know when to use them.

Gain a solid foundation in organic chemistry and the chemistry of the human body, as well as a better understanding of biochemical interactions with INTRODUCTION TO ORGANIC AND BIOCHEMISTRY, 8E, International Edition. Designed to make challenging information accessible to everyone and ideal for those entering health careers, this proven book shows chemistry applied to normal human biochemical pathways and discusses biochemical conditions present in disease.

Key Features: • Discusses the clinical and applied aspects of forensic medicine through illustrative case scenarios and reports. • Addresses the needs of clinicians and forensic medicine specialists in writing medico-legal reports for specific cases. • Provides evidence-based solutions to medicolegal and ethical dilemma faced during routine practice.

As with the much-praised prior editions, the third edition of Strelkauskas' Microbiology: A Clinical Approach remains a comprehensive introductory textbook written specifically for pre-nursing, nursing and allied health students. Clinically relevant throughout, it uses the theme of infection as its foundation, fitting closely with the 'One Health' approach that is considered increasingly central to the effective control of zoonoses and to combatting antimicrobial resistance. The third edition has been thoroughly revised and updated to reflect the latest developments, including the emergence of the SARS-CoV-2 virus and associated COVID-19 pandemic. The book is accompanied by a robust instructor ancillary package that allows educators to incorporate readily the book’s unique approach into their lectures and includes additional materials for students to supplement classroom learning and encourage and support study and self-reflection. Key Features: Student-focused, with all elements carefully designed to help students engage with and understand difficult concepts and to spark and hold interest Dedicated learning skill section introduces practical strategies for improving comprehension and retention Numerous text features further support learning and teaching, including chapter overviews, fast facts, case studies and human stories, and ‘why is this important?’ highlights A variety of question-and-answer types for self-testing and reflection to support and assess basic learning, to challenge students to integrate important concepts and ask students to apply what they have just learned to a specific clinical setting or problem All supported by a comprehensive suite of online resources including lecturer support material and, for students, interactive questions, lecture notes, MicroMovies and the BugParade The book is an excellent resource to guide and support inter-professional education in the health sciences and an ideal entry-point to the subject for anyone coming from another discipline and invaluable supplementary reading for medical, microbiology and biomedical science students.

This two volume set will analyse the modifying effects of both organic and inorganic nanofillers on the mechanical properties of polymer nanocomposites. Detailing processing, characterization, properties, and applications, the books demonstrate how choosing the right nanofiller can encourage innovation, sustainability and cost effective manufacturing. The set includes the following volumes: - Volume one looks at organic nanofillers including natural fibres and membranes - Volume two focuses on inorganic nanofillers including metallic foams, metal oxides and hydrogels These volumes will be of interest to engineers involved with inorganic nanofillers, in a variety of industries including automotive, aerospace and biomedical engineering.

The coronavirus pandemic forces us to rethink our contemporaneity. It has brought to the surface dimensions of human fragility that partially contradict the euphoria and human hubris of the fourth industrial revolution (artificial intelligence). It has also aggravated the social inequality and racial discrimination that characterize our societies. The book argues that the virus, rather than an enemy, must be viewed as a pedagogue. It is trying to teach us that the deep causes of the pandemic lie in our dominant mode of production and consumption. The systemic overload of natural resources creates a metabolic rift between society and nature that destabilizes the habitat of wild animals and the vital cycles of natural regeneration whereby pandemics become an increasingly recurrent phenomenon. In trying to take seriously this lesson the book proposes a paradigmatic shift from the current civilizatory model to a new one guided by a more equitable relationship between nature and society and the priority of life, both human and non-human.

A focus throughout on lifespan perspectives and a consideration of palliative care across all ages. Consideration of different cultural perspectives, beliefs, thoughts and practices outside Western societies and dominant paradigms. Integrates primary research throughout, including a focus on contemporary research from social media. Complements mainstream psychological approaches to life-limiting illness by exploring death, dying and palliative care with a critical health psychology lens.

How the prized matsutake mushroom is remaking human communities in China-and providing new ways to understand human and more-than-human worlds What a Mushroom Lives For pushes today's mushroom renaissance in compelling new directions. For centuries, Western science has promoted a human- and animal-centric framework of what counts as action, agency, movement, and behavior. But, as Michael Hathaway shows, the world-making capacities of mushrooms radically challenge this orthodoxy by revealing the lively dynamism of all forms of life. The book tells the fascinating story of one particularly prized species, the matsutake, and the astonishing ways it is silently yet powerfully shaping worlds, from the Tibetan plateau to the mushrooms' final destination in Japan. Many Tibetan and Yi people have dedicated their lives to picking and selling this mushroom-a delicacy that drives a multibillion-dollar global trade network and that still grows only in the wild, despite scientists' intensive efforts to cultivate it in urban labs. But this is far from a simple story of humans exploiting a passive, edible commodity. Rather, the book reveals the complex, symbiotic ways that mushrooms, plants, humans, and other animals interact. It explores how the world looks to the mushrooms, as well as to the people who have grown rich harvesting them. A surprise-filled journey into science and human culture, this exciting and provocative book shows how fungi shape our planet and our lives in strange, diverse, and often unimaginable ways.

There are over 400 CHD risk factors that need to be evaluated, prevented, and treated. It is crucial that we have tests for early identification, prevention and treatment of CHD and MI. CHD remains the number one cause of morbidity and mortality in the United States. This book discusses not only older traditional risk factors of heart disease, but new considerations including updated genetic material which is state of the art. This book provides a new and detailed explanation of the causes of CHD and MI based on genetics, blood tests, urine tests. vascular tests and cardiac tests. Once this information is understood and applied to the patient the control of CHD risk factors, cardiovascular complications such as MI and heart failure will be improved with fewer adverse effects and lower cost. No other heart book on the market has this updated and extensive data based on published trials and the experience of the author. Chapters are written in an easy- to -understand format and all medical terms are defined for the reader. Tables and figures are provided each chapter to better illustrate what is described in the text, provide concise, understandable, and valuable information. All references are numbered in the text and then listed at the end of each chapter - the references provide additional medical information. Summaries and Key Take Away Points are provided at the end of each chapter. A sources section is listed at the end of the book which lists contact information for the best nutritional supplement companies, lab, and testing companies, as well as other important sources mentioned in the text of the book.

Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.

How dogs defied science and changed the way we think about animals What do dogs really think of us? What do dogs know and understand of the world? Do their emotions feel like our own? Do they love like we do? Driven by his own love of dogs, Charles Darwin was nagged by questions like these. To root out answers, his contemporaries toyed with dog sign language. To reveal clues, they made special puzzle boxes and elaborate sniff tests using old socks. Later, the same perennial questions about the minds of dogs drove Pavlov and Pasteur to unspeakable cruelty in their search for truth. These big names in science influenced leagues of psychologists and animal behaviourists, each building upon the ideas and received wisdom of previous generations but failing to see what was staring them in the face - that the very methods humans used to study dogs' minds were influencing the insights reflected back. To discover the impressive cognitive feats that dogs are capable of, a new approach was needed. Treated with love and compassion, dogs would open up their unique perspective on the world, and a new breed of scientists would be provided answers to life's biggest questions. Wonderdog is the story of those dogs - a historical account of how we came to know what dogs are capable of. It's a celebration of animal minds and the secrets they hold. And it's a love letter to science, through the good times and the bad.

This book provides a well-focused and comprehensive overview of the history and background of nanocarbon based materials like carbon nanotubes, graphene, and fullerenes. It discusses their structure, synthesis, properties and modifications for making various advanced materials. The authors focus on their use in the health care sector as therapeutic agents in pharmacy and medicine, in diagnosis and analysis in pharmacy and medicine, as biosensors, gene and drug delivery, cancer therapy, biosensing and bioimaging, go-based antibacterial materials, and as a promising antioxidant and GO-based scaffold for cell culture. The authors also showcase the application potential of advanced nanocarbon based materials by examining the biomedical applications developed via novel advanced designing, in which the technologies will be adopted and the end users can be benefited. Finally the authors discuss the increasing research on carbon based materials, along with the challenges they are currently facing along with possible solutions that may result in the availability of the accessible, reliable and cost-efficient technology. The potential user for this book may be medical practitioners, biologists, pharmacists, and chemists.This book covers in-depth knowledge of processing parameters for making nanocarbon based material for high end applications in the biomedical and pharmaceutical fields.

An environmental historian delves into the history, science, and philosophy of a paradoxical pursuit: the century-old quest to design natural places and create wild species. Environmental restoration is a global pursuit and a major political concern. Governments, nonprofits, private corporations, and other institutions spend billions of dollars each year to remove invasive species, build wetlands, and reintroduce species driven from their habitats. But restoration has not always been so intensively practiced. It began as the pastime of a few wildflower enthusiasts and the first practitioners of the new scientific discipline of ecology. Restoration has been a touchstone of US environmentalism since the beginning of the twentieth century. Diverging from popular ideas about preservation, which romanticized nature as an Eden to be left untouched by human hands, and conservation, the managed use of natural resources, restoration emerged as a "third way." Restorationists grappled with the deepest puzzles of human care for life on earth: How to intervene in nature for nature's own sake? What are the natural baselines that humans should aim to restore? Is it possible to design nature without destroying wildness? Laura J. Martin shows how, over time, amateur and professional ecologists, interest groups, and government agencies coalesced around a mode of environmental management that sought to respect the world-making, and even the decision-making, of other species. At the same time, restoration science reshaped material environments in ways that powerfully influenced what we understand the wild to be. In Wild by Design, restoration's past provides vital knowledge for climate change policy. But Martin also offers something more-a meditation on what it means to be wild and a call for ecological restoration that is socially just.

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities.

Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development.

The essential chemistry for health careers and everyday life Guinn's, Essentials of General, Organic and Biochemistry uses health and medicine as the framework for learning the fundamentals of chemistry in this student-centred one-semester text. The newly revised 3rd edition focuses on core concepts and necessary math skills and features a revamped organization to align with traditional course organization and shorter, more condensed chapters. Easily digestible content and medical applications help reduce student anxiety and make chemistry meaningful for students preparing for future careers in nursing and other allied health professions. Essentials of General, Organic and Biochemistry is now supported in Achieve, Macmillan's new online learning platform. Achieve is the culmination of years of development work put toward creating the most powerful online learning tool for chemistry students. Achieve includes an interactive eBook as well as our renowned assessments and new tutorial questions. Students will be able to focus their study with adaptive quizzing and more clearly see the relevance of chemistry through case studies.

Discusses advancements in the field of Human Machine Interface. Provides practical knowledge in biomedical signal processing, AI and ML using MATLAB. Introduces biomedical signals for HMI applications. Discusses Augmented Reality/Virtual reality based HMI. Explores advancements in nanotechnology, user interface design and interactive systems.

Details the use of advanced AFMs and addresses all types of functional AFMs First book to focus on application of AFM for energy research Enables readers to operate an AFM successfully and to understand the data obtained Covers new achievements in AFM instruments, including higher speed and resolution, automatic and deep learning AFM, and how AFM is being combined with other new methods like IR and Raman microscopy

This book will take readers on a flying visit round the world, scouring the seven continents for the biggest, brightest and best birds on the planet. Urban Jungle creator Vicky Woodgate perfectly captures the brilliance of the bird world, each chapter taking us to a new continent and introducing birds from hummingbirds to hawks, and parrots to penguins. With a vintage travelogue feel, vibrant artwork and fascinating annotations, it is a book that will appeal to wildlife lovers from 7 to 70!

Understand the basics of a thriving interdisciplinary research field Microbial electrochemistry is a subfield of bioelectrochemistry which concerns interactions between microbial organisms and electrically active surfaces such as electrodes. Its growth as a subject of research has been rapid in recent years, and its technological applications are many, particularly as the race to find sustainable organic energy sourcesaccelerates. Fundamentals of Microbial Electrochemistry offers an accessible overview of this interdisciplinary subject and its potential applications. Moving smoothly from the general to the specific, it offers both fundamental principles and some of the most relevant specific examples, such as microbial fuel cells, making it the ideal choice for building a working knowledge of this exciting new field. Its solid foundation of microbial electrochemical technologies also serves as a starting point for a wide range of applied research areas. Fundamentals of Microbial Electrochemistry readers will also find: Carefully designed artistic illustrations Hands-on exercises throughout to facilitate entry into laboratory work Numerous illustrative examples and calculations designed to demonstrate and reinforce key principles Fundamentals of Microbial Electrochemistry is the perfect point of entry into this growing field for both students and researchers.

General compendium of HDAC inhibitors with deep emphasis on toxicity issues of synthetic HDAC inhibitors Various groups of natural HDAC inhibitors, their representatives and premier sources Cyclic tetrapeptides of natural origin and their importance as cancer chemotherapeutic agents Hydroxamates and depsipeptides from natural sources and their promising role in cancer therapy Natural Flavonoids, their HDAC inhibitory tendency and marvellous anticancer activity Non-flavonoid natural HDAC inhibitors and their pleasing cytotoxic effects towards cancer models Combined therapy involving natural flavonoids with other anticancer molecules for synergistic and additive benefits against cancer models Non-flavonoid HDAC inhibitors and conventional drugs in collaborative mode against aggressive malignancies Nanotechnology based delivery of natural HDAC inhibitors for greater therapeutic efficacy over traditional combinatorial therapy

Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility provides cutting-edge information and solutions to help support the worldwide rise of fertility challenges. It addresses common, yet not commonly known, root-causes of oxidative stress that are at the heart of reproductive issues (and all chronic health issues). These solutions can help enhance the outcomes of Assisted Reproductive Technologies (ART) or support women to avoid them altogether. Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility will show you how to improve cell health (including egg and sperm), lower inflammation, balance nervous system functioning, and optimize genetic expression, allowing the body to return to its naturally fertile state. It details information on numerous root causes of health-derailing inflammation and oxidative stress, while the appendices discuss the genetic and biochemical pathways related to these topics. Each chapter also provides easy "Action Steps" that can be implemented immediately. Chapter topics include iron dysregulation; oxalates; mold/mycotoxins; phase 2 liver detoxification pathways; fat utilization; introductory information on genetics, epigenetics, and nutrigenomics; everything one needs to know about histamine intolerance; and how these factors adversely affect metabolic and reproductive functions. Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility is the handbook for people wanting to achieve and sustain a healthy pregnancy. It highlights lesser-known causes of fertility challenges the reader can learn how to investigate. This book also serves as a reference guide for practitioners, providing them with additional tools to add to their repertoires when other protocols have not been effective. It may also provide clarity as to why other protocols did not work, and will enable the practitioner to custom-tailor protocols for each patient.