Cilia: From Mechanisms to Disease, Part A, Volume 175 in the Methods in Cell Biology series, offers a range of techniques and protocols that can be used to study aspects of this interesting cellular organelle both in vitro and in vivo. In this volume, different study models are used, such as human cell lines, Mus musculus, Danio rerio, Paramecium caudatum or Chlamydomonas reinhardtii. Besides, protocols to study the genesis, morphology, composition and function of cilia will be addressed. In this book, the ciliary study will be realized by using different techniques such as flow cytometry, time-lapse images of fluorescent ciliary proteins, the use of organoids, the evaluation of the ciliary-GPCR dynamics or genetic modulation by using CRISPR/Cas9.

Myeloid-Derived Suppressor Cells, Volume 378, includes comprehensive and detailed reviews on the current advances in myeloid derived suppressor cells, an immature, heterogenous cell population from the myeloid lineage that has been extensively described in the last decades due to its potent immunosuppressive activity in a variety of pathologies. Reviews maintain a high standard by publishing invited articles on important and timely topics authored by prominent researchers. The articles published in IRCMB have a high impact. IRCMB ranks high amongst scientific journals dealing with cell biology.

Advanced Technologies in Wastewater Treatment: Oily Wastewaters focuses on characteristics and innovative treatment technologies of oily wastewater from various resources. Primary and physical treatment methods such as absorption, adsorption, followed by common techniques like coagulation and fluctuation are discussed in detail. Applications of other advanced methods for the treatment of oily wastewaters like utilization of membranes and stripping gases are covered as well. Finally, novel technologies applied in purification of oily wastewaters such as photocatalytic degradation and biological processes are reviewed and future outlooks and prospects are also illustrated.

Game-Based Learning in Education and Health: HCI and BCI Advances and Dilemmas, Volume 276 in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Math computerized games in the classroom: a Number Line Training in Primary School Children, Digital games for learning basic arithmetic at home, Game-Based Assessment of Cognitive Function among Children and Adolescents: A Systematic Review and Meta-Analysis, Different aspects of fraction understanding are associated selectively with performance on a fraction learning game, and more.

Marvel at the neuroscientific reasons why smart teens make dumb decisions! Behold the mind-controlling power of executive function! Thrill to a vision of a better school for the teenage brain! Whether you're a parent interacting with one adolescent or a teacher interacting with many, you know teens can be hard to parent and even harder to teach. The eye-rolling, the moodiness, the wandering attention, the drama. It's not you, it's them. More specifically, it's their brains. In accessible language and with periodic references to Star Trek, motorcycle daredevils, and near-classic movies of the '80s, developmental molecular biologist John Medina, author of the New York Times best-seller Brain Rules, explores the neurological and evolutionary factors that drive teenage behavior and can affect both achievement and engagement. Then he proposes a research-supported counterattack: a bold redesign of educational practices and learning environments to deliberately develop teens' cognitive capacity to manage their emotions, plan, prioritize, and focus. Attack of the Teenage Brain! is an enlightening and entertaining read that will change the way you think about teen behavior and prompt you to consider how else parents, educators, and policymakers might collaborate to help our challenging, sometimes infuriating, often weird, and genuinely wonderful kids become more successful learners, in school and beyond.

The essays from leading tree scientists collected in In the Circle of Ancient Trees read like fervent love letters to ten of the most ancient and important tree species on the planet … Awe-inspiring.”—Foreword Reviews

This captivating book about dendrochronology—the study of tree rings—uncovers the stories of 10 species of ancient trees, their unique environments and climates, and what they have to tell us about the history of our world.

Ingrained and encrypted in the growth rings of every tree are stories of its environment and the events to which it bore witness. In the Circle of Ancient Trees presents the stories of ten ancient tree varieties in engrossing chapters written by ecologists with specialist knowledge. From the Bosnian pine to the giant sequoia, from the United States, to Europe, to South America, these essays explore how human and environmental history share common roots, while drilling down into the ecology, persistence, and resilience of trees.

Advances in Clinical Chemistry, Volume 112 highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Heterogeneity in Major Depressive Disorder: The need for Biomarker-based and Personalized Treatments, Advances in exosome analysis, Translational Proteomics and Phosphoproteomics: Tissue to Extracellular Vesicles, Immune Checkpoint Therapy, Tumor Immunology, and Biomarkers in Non-Small-Cell Lung Cancer, Advances in Congestive Heart Failure Biomarkers, Fluid biomarkers in Alzheimer's disease, and more.

Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more. Other sections in this new release include Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications.

Integrated Methods in Protein Biochemistry: Part B, Volume 678 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Precise modification of native proteins, purification, and analysis of bioconjugates, NanoBiT-based methods to monitor the activation and modulation of RTKs, The interplay of G-protein ss? subunit and PLC-ss enzyme in PIP2 hydrolysis and downstream signaling, Structure and function of bacterial secretion system, Tools and protocols for probing protein sumoylation, Spectroscopic analysis of cysteine dioxygenase: a mammalian thiol-dioxygenase, DeGlyPHER: MS-based analysis of viral spike N-glycoforms, and more. Additional sections cover Covalent protein painting: MS-based protein footprinting, Characterization of GPCR signaling complexes using negative-staining electron microscopy, Probing protein misfolding and dissociation with free electron laser, Optimized protocol for the characterization of Cas12a activities, Proximity proteomics for the identification and characterization of extracellular vesicles, Structural and Functional characterization of lytic polysaccharide monooxygenases, and much more.

Meiosis in Development and Disease, Volume 151 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as The initiation stages of meiosis, The molecular basis and dynamics of meiotic cohesions, and their significance in human infertility, Chromatin, recombination, and the centromeres, Sites and structures that mediate segregation when crossing over calls out sick/Life (or at Least Meiosis) Without Crossing Over, Crossover maturation inefficiency, Non coding RNA mediated gene regulation in meiosis, Short chromosomes in meiotic recombination, Chromatin level changes during meiosis initiation vs. oncogenesis, and much more. Other sections of note include Chromosomal speciation revisited: Meiotic recombination and synapsis of evolutionary diverged homologs, Recombination suppression at specific chromosome regions, Unwinding during stressful times - mechanisms of helicases in meiotic recombination, Meiotic functions of PCH-2/TRIP13 and HORMADs, Crossover interference, Checkpoint control in meiotic prophase: Idiosyncratic demands require unique characteristics, The breadth of meiotic drive genes and mechanisms across the tree of life, and many more interesting topics.

Indigenous Fermented Foods for the Tropics provides insights on fermented foods of the Tropics, particularly Africa, Asia and South America, highlighting key aspects and potential developments for these food products. Sections provide an overview on the production and composition (nutritional, physicochemical, health beneficial and microbiota) of these indigenous fermented foods in the tropics, focus on innovative techniques for investigating the composition of these fermented food products and improvement of the fermentation process to yield better nutritional constituents, health beneficial components and sensory qualities, and cover safety aspects to be considered in fermented foods. Final sections provide insights on the packaging and marketing of these food products. This book provides new perspectives and recent information to complement existing texts on indigenous fermented foods serving as a valuable reference text for detailed insights into indigenous fermented foods of the tropics.

Plant-Microbe Interaction - Recent Advances in Molecular and Biochemical Approaches: Overview of Biochemical and Physiological Alteration During Plant-Microbe Interaction, Volume One covers the role of these plant microbes and their interaction between plants and microbes. These beneficial microbes, such as bacteria and fungi are also known as plant growth-promoting rhizobacteria (PGPR) through a biochemical reaction that may improve induced systemic resistance in the plant host via indirectly (against phytopathogens) or directly (the solubilization of mineral nutrients) by producing phytohormones and specific enzymes such as 1-aminocyclopropane-1-carboxylate deaminase. The book covers biochemical processes such as physiological, metabolic, etc. of plant and microbe interactions, the biochemistry of biological systems, the interaction of biological systems above-ground or within the rhizosphere, and the history of growth promoting microbiomes, their roles in phytoremediation efficiency, physiological and biochemical studies, chemical communication and signaling mechanisms.

Neurobiology of Addiction and Comorbid Disorders, Volume 156, in the International Review of Neurobiology series, highlights new advances in the field of neurobiology, with this new volume presenting interesting chapters on topics such as Pain + Alcohol, Pain + Opioids, Traumatic Stress + Alcohol, Traumatic Stress + Cannabinoids, Traumatic Brain Injury and the Misuse of Alcohol, Opioids, and Cannabis, Depression + Addiction, Microbiome/cytokines + Addiction, Cognitive disorders + Alcohol, Neural stem cells, Neurogenesis and Addiction, Food Addiction, and Poly-drug Addiction.

Secretory Proteins, Volume 133 in the Advances in Protein Chemistry and Structural Biology series highlights new advances in the field, including chapters on Proprotein Convertases regulate trafficking and maturation of key proteins within the secretory pathway, Secretory Proteins in Cancer Diagnosis, Senescent Cells and SASP in Cancer Microenvironment: new approaches in cancer therapy, Autophagy for secretory protein: Therapeutic targets in cancer, Secretory proteins and pathways of secretion of osteosarcoma, Monocyte secretory proteins as drug targets for arresting progression of atherosclerosis, The secretory phenotypes of envenomed cells: insights into venom cytotoxicity, Macromolecules for secretory pathway in SARS-CoV-2 infection, and much more. Other sections cover Exploring the role of secretory proteins in the human infectious diseases diagnosis and therapeutics, Secretory proteins in orchestration of microbial pathogenesis- the curious case of Staphylococcus aureus, Influence of pathological mutations in Aspartylglucosylamine Deaspartylase causing Aspartylglucosaminuria: an in silico approach, and Change in conformational dynamics of Lipase A secretory protein upon mutation causing Wolman disease.

Regulation of Downstream Targets, Volume 134 in the Advances in Protein Chemistry and Structural Biology series, presents interesting chapters on topics such as Transcriptional regulatory mechanisms and signaling networks in Viral Infections, Identification of potential key genes associated with pathogenesis and prognosis of endometrial cancer based on Integrated Bioinformatics Approaches, Differential regulation of genes in stage IB pancreatic cancer associated with increased risk of metastasis, AMPK-related LKB1-downstream targets, A compilation of bioinformatic approaches to identify novel downstream targets for the detection and prophylaxis of cancer, Protein phosphatases and their targets: Critical determinants of signaling pathway in plants, and more. Other sections cover Calcium decoders and their targets: The holy alliance that regulate cellular responses, Importin alpha family NAAT/IBB domain: functions of a multi-faceted long chameleon sequence, Aurora Kinase A and related downstream molecules: A Potential Network for Cancer Therapy, Emerging Role of Heat Shock Proteins in Cardiovascular Diseases, Function, Structure, Evolution, Regulation and Drug Target Relevance of Arylalkylamine N-acetyltransferase, and Analysis of signaling cascades from myeloma cells treated with pristimerin.

Mitochondria and Bacterial Pathogens, Volume 374, Part A. Mitochondria control various processes that are integral to cellular and organismal homeostasis, including Ca2+ fluxes, bioenergetic metabolism, and cell death. Perhaps not surprisingly, multiple pathogenic bacteria have evolved strategies to subvert mitochondrial functions in support of their survival and dissemination. In the IRCMB volume 375, the authors discus different pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells.

A New York Times bestseller and international sensation, this “stimulating and important book” (Financial Times) is a fascinating dive into the purpose and power of slumber.

With two appearances on CBS This Morning and Fresh Air's most popular interview of 2017, Matthew Walker has made abundantly clear that sleep is one of the most important but least understood aspects of our life. Until very recently, science had no answer to the question of why we sleep, or what good it served, or why we suffer such devastating health consequences when it is absent. Compared to the other basic drives in life—eating, drinking, and reproducing—the purpose of sleep remains more elusive.

Within the brain, sleep enriches a diversity of functions, including our ability to learn, memorize, and make logical decisions. It recalibrates our emotions, restocks our immune system, fine-tunes our metabolism, and regulates our appetite. Dreaming creates a virtual reality space in which the brain melds past and present knowledge, inspiring creativity.

In this “compelling and utterly convincing” (The Sunday Times) book, preeminent neuroscientist and sleep expert Matthew Walker provides a revolutionary exploration of sleep, examining how it affects every aspect of our physical and mental well-being. Charting the most cutting-edge scientific breakthroughs, and marshalling his decades of research and clinical practice, Walker explains how we can harness sleep to improve learning, mood and energy levels, regulate hormones, prevent cancer, Alzheimer’s and diabetes, slow the effects of aging, and increase longevity. He also provides actionable steps towards getting a better night’s sleep every night.

Clear-eyed, fascinating, and accessible, Why We Sleep is a crucial and illuminating book. Written with the precision of Atul Gawande, Andrew Solomon, and Sherwin Nuland, it is “recommended for night-table reading in the most pragmatic sense” (The New York Times Book Review).

Handbook of Food and Feed from Microalgae: Production, Application, Regulation, and Sustainability is a comprehensive resource on all aspects of using microalgae in food and feed. This book covers applied processes, including compounds found in microalgae applicable in food and feed, food products developed with microalgae biomass in the composition, the use of microalgae in animal nutrition, and challenges and recent advances. Written by global leading experts on microalgae, the book's sections discuss the fundamentals of food and feed from microalgae, including its biodiversity, biogeography, genomics, nutritional purposes and compounds found within microalgae like proteins, vitamins and antioxidants. In addition, the book explains the incorporation of microalgae into meat, dairy, beverages and wheat products, as well as in real-world food applications in aquaculture, mollusk, poultry and pet feeding. The last two sections cover challenges and issues such as bioavailability and bio-accessibility and how to address safety, regulatory, market, economics and environment concerns.

The Veterinarian's Guide to Animal Welfare provides an overview of various aspects of animal welfare that are particularly relative to the veterinary profession. The book explores various ways of viewing and assessing welfare, as well as the numerous factors that influence perceptions. Emphasis is placed on contemporary issues across, and within, major species groups. The book's authors are internationally known experts in the veterinary aspects of animal welfare and have written numerous articles on animal welfare, behavior, euthanasia and the human-animal bond. This book is written for the veterinary profession and was designed to be used as a textbook for animal welfare courses at colleges and schools of veterinary medicine. It complements the Model Curriculum for the Study of Animal Welfare (AVMA 2015) and its attendant course syllabus. This is an important resource for graduate veterinarians seeking to improve their understanding of the numerous aspects of animal welfare.

Radiation Oncology and Radiotherapy, Part B, Volume 174 in the Methods in Cell Biology series, highlights advances in the field, with this new volume presenting interesting chapters on timely topics including CT-assisted focal irradiation of tumors in mice, Methods to preserve correct dosimetry in small animal irradiators, Monitoring TGFbeta signaling in irradiated tumors, Cytofluorometric characterization of the lymphoid compartment of irradiated tumors, Cytofluorometric characterization of the myeloid compartment of irradiated tumors, Mass cytometry to characterize the immune infiltrate of irradiated tumors, Characterization of the immune infiltrate in irradiated mouse tumor by multiplex immunofluorescence, and much more. Other chapters cover Methods to study FOXP3+CD8+ cells in irradiated bone metastases, Luminex-based characterization of cytokine signaling by irradiated tumors, Explant-based assessment of anticancer immunity in irradiated tumors, Pipeline to characterize the TCR repertoire of irradiated tumors, Pipeline to identify tumor neoantigens exposed by radiation, and more.

Oxidative Stress Response in Plants, Volume 105 covers environmental stress conditions and the accumulation of reactive oxygen species (ROS). During many stress conditions such as salt, drought, heat, and pathogen infection, changes in metabolic fluxes and alterations in enzymatic activities result in the accumulation of ROS, a major contributor to loss of growth and productivity. High levels of ROS can lead to oxidative stress which damages proteins and DNA, ultimately resulting in plant cell death. This volume provides comprehensive insights into ROS biology in plants, with a focus on plant growth and development, plant defense responses, and plant acclimation to challenging environments. On the other hand, ROS evolves into potent signaling molecules that play crucial roles in abiotic and biotic stress sensing, integration of different environmental signals, and activation of stress-response networks, thereby contributing to the establishment of improved stress resilience.