Contaminants of emerging concern in the marine environment: current challenges in marine pollution reviews the available data in relation to contaminants of emerging concern (CECs) in the marine environment: main sources, transport pathways, distribution in seawater and sediments, bioaccumulation, and biological effects. Each chapter recaps the most relevant information about the main groups of CECs, describing the particularities and specificities of each group and focusing on the most relevant individual contaminants. CECs are not regulated substances, and therefore not considered in national and international monitoring programs, even though they may have a potential impact on the environment due to their continuous input, relative persistence, and/or toxicity. CECs are relevant not only in continental and coastal areas close to their main sources, but also in the open sea, because some of them are likely to be transported long distances through air deposition or absorbed into particulate material. The persistence of many degradable substances in the marine environment increases when they are absorbed into particulate material/sediments and/or when they are subjected to anaerobic conditions that slow down the degradation kinetic of many contaminants. Bioaccumulation of several CECs has been confirmed in different coastal organisms; however, in general, the information available (species and trophic levels considered) is very limited because most studies are mainly focused on specific coastal areas. This book offers useful information about not regulated contaminants that are not considered in international monitoring programs but have potential impacts in coastal and open-sea areas. Therefore reading the book will allow them to improve their view about the real impact of current-use contaminants in the marine environment.

Advances in Dairy Microbial Products describes the importance and utility of microbial products used in dairy products. This book explains the makeup of these products in a scientifically sound yet simple manner. The appeal of this book is its holistic approach to addressing the different aspects of the dairy industry, from basic dairy microbial biochemistry to production of dairy products and their nutrient quality, and finally to machine learning applications in dairy industry. Comprised of chapters written and edited by international authorities and researchers with top expertise in dairy products, it offers both established and cutting-edge solutions to the numerous challenges commonly encountered in the industrial processing of milk and the production of milk products. This book offers a highly practical approach to the topic, addressing and tackling the problems faced in the workplace by dairy technologists. Researchers and practitioners will find this book to be an ideal source of thorough and up-to-date information on dairy microbial products while also appealing to beginners seeking to understand how advanced dairy technologies can increase the efficiency of current techniques.

Essential Oils: Extraction, Characterization and Applications covers sixteen essential oils from different herbal and aromatic plants, including production, composition and extraction techniques such as distillation, chemistry and properties, characterization and applications. The book also presents their safety, toxicity and regulation, alongside trade, storage, stability and transport concepts. Essential oils in plants, extraction and analysis, and current trends in the use of essential oils, like aroma therapy, agro-food and non-food usage are thoroughly explored. Remaining chapters are dedicated to different essential oils, including lavender, peppermint, sandalwood, citrus, eucalyptus, tea tree, clove, ginger, cinnamon, nutmeg, rosewood, juniper and pine, patchouli, clary, and more. Edited by a global team of experts in essential oils, this book is designed to be a practical tool for the many diverse professionals who develop and market essential oils.

Developing Sustainable and Health Promoting Cereals and Pseudocereals: Conventional and Molecular Breeding reviews the most recent developments in the fields of cereal and pseudocereal breeding, with particular emphasis on the latest biotechnological techniques likely to lead to breakthrough changes in plant breeding. The book provides comprehensive information on the use of genetic resources or pre-breeding activities to improve health-related properties of cereals and pseudocereals. The text also explores targeted field-management practices and the latest in biotechnological methodologies, and offers a cohesive overview necessary for understanding the potential impacts and benefits of improved production of cereals and pseudocereals with high-nutritional value.

Advances in Clinical Chemistry, Volume 113, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry with sections in this release focusing on Biosensors for saliva biomarkers, Biochemistry and pathophysiology of the Transient Potential Receptor Vanilloid 6 (TRPV6) calcium channel, Protein Glycation in Diabetes Mellitus, Biomarkers of Oxidative Stress and Reproductive Complications, Cortisol: Analytical and Clinical Determinants, and Hemophilia A: Emicizumab monitoring and impact on coagulation testing.

Hormones and Epigenetics, Volume 122, the latest release in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting timely, interesting chapters written by an international board of authors.

Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders, Volume 168 in the International Review of Neurobiology series, highlights advances in the field, with this new volume presenting interesting chapters on topics such as mGlu receptors in Parkinson's disease, Metabotropic glutamate receptors in estradiol-mediated motivated behaviors in females, mGlu regulation of sleep, Implications for sleep disruptions in psychiatric disorders, Mechanisms of mGlu receptor trafficking; alterations by methamphetamine, Group I mGlu and cocaine seeking, The role of mGlu receptors in fear and anxiety, Regulation of Alcohol Consumption, Reward, Dependence, and Perception by Metabotropic Glutamate Receptor Signaling, and mGlu5 as a biomarker for psychiatric disorders.

Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors which are associated with different organs and that play a key role in normal functioning in the body, including somatostatin, Mas receptor, AMPA, Dopamine, 5-HT1-2, GABA, GPCR, nuclear receptor, Integrin, BCR, CRHR1, etc. Chapters in this new release include Internalization of somatostatin receptors in brain and periphery, Mas receptor, signaling and trafficking in health and disease, Endocytosis of AMPA receptors: Role in neurological conditions, Endocytosis of dopamine receptor: Signaling in brain, and more. Additional chapters cover Endocytosis of LXRs: Signalling in liver, Endocytosis of LDL receptor: Importance in cardiovascular diseases, Advances in the molecular level understanding of G-protein-coupled receptor, Nuclear receptor: Structure and function, Integrin receptor trafficking in health and disease, B Cell Receptor (BCR) endocytosis,CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling, and much more.

Given the fundamental challenges to society in this era, a radical rewrite of how we approach science and culture is necessary. This handbook applies Perceptual Control Theory (PCT) to achieve a much needed convergence across the physical, life and social sciences, the humanities and arts. In doing so it addresses challenges such as mental illness, dementia, cancer care, toxic masculinity and societal oppression. It also reveals how PCT can be applied to practical issues such as understanding healthcare service implementation and human-machine interaction, as well as deeper questions such as consciousness and imagination. This second volume of the successful interdisciplinary handbook offers rich examples of how the unifying perceptual control framework can provide a viable alternative to existing theories and methodologies for a timely paradigm shift.

Medicinal Chemistry of Anticancer Drugs, Third Edition provides an updated resource for students and researchers from the point-of-view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. The new edition includes updated sections on the hot topic of cancer immunotherapy, cancer polypharmacology, multitargeted cancer therapy, medicinal chemistry of cancer diagnosis, theragnostic anticancer agents, and pre-mRNA processing in cancer. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a unique and valuable perspective from the point-of-view of medicinal chemistry and drug design. It will be useful to undergraduate and postgraduate students of medicinal chemistry, pharmacology, biological chemistry, pharmacy and other health sciences. Researchers and practitioners will find a comprehensive treatment of the topic and a large number of references, reviews and primary literature.

Advances in Carbohydrate Chemistry and Biochemistry, Volume 80 highlights new advances in the field, with this new volume presenting interesting chapters on a range of topics, including Vinyl Sulfone-Modified Carbohydrates: Michael Acceptors and 2p Partners for the Synthesis of Functionalized Sugars, Enantiomerically Pure Carbocycles and Heterocycles and a Biographical Memoire for Leslie Hough.

Advances in Biomembranes and Lipid Self-Assembly, Volume 34, formerly titled Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for the study of cell membranes, lipid model membranes and lipid self-assemblies, from the micro- to the nanoscale. As planar lipid bilayers are widely studied due to their ubiquity in nature, this book presents research on their application in the formulation of biomimetic model membranes, and in the design of artificial dispersion of liposomes. Chapters cover Physical properties of SOPC lipid membranes containing cholesterol by molecular dynamics simulation, Exciting membrane fluctuations - more than thermal stimulation, Fluctuations shaping bio-membrane adhesion, and more.

Myxomycetes: Biology, Systematics, Biogeography and Ecology, Second Edition provides a complete collection of general and technical information on myxomycetes microorganisms. Its broad scope takes an integrated approach, considering a number of important aspects surrounding their genetics and molecular phylogeny. The book treats myxomycetes as a distinct group from fungi and includes molecular information that discusses systematics and evolutionary pathways. Written and developed by an international team of specialists, this second edition contains updated information on all aspects of myxomycetes. It incorporates relevant and new material on current barcoding developments, plasmodial network experimentation, and non-STEM disciplinary assimilation of myxomycete information. This book is a unique and authoritative resource for researchers in organismal biology and ecology disciplines, as well as students and academics in biology, ecology, microbiology, and similar subject areas. Cover image used with permission from Steve Young Photography

New Methods and Sensors for Membrane and Cell Volume Research, Volume 88 provides an overview of novel experimental approaches to study both the cell membrane and the under-membrane space - the cytosol, which have lately began drawing renewed attention. The book's overall emphasis is on fluorescent and FRET-based sensors, however, other optical (such as variants of transmission microscopy) and non-optical methods (neutron scattering and mass spectrometry) also have dedicated chapters. This volume provides a rare review of experimental approaches to study intracellular phase transitions, as well as anion channels, membrane tension and dynamics, and other topics of intense current interest.

Journey back to the age of dinosaurs and uncover the secrets of some of the prehistoric world's most remarkable beasts. From the Tyrannosaurus rex and Diplodocus to the Triceratops and Stegosaurus, get up close and discover how these fascinating creatures lived, hunted, evolved and ultimately died out. In Discovering Dinosaurs we've gathered together some of the most fascinating information available to bring you everything you need to know about the incredible creatures that roamed our Earth millions of years ago. Why did Stegosaurus travel in herds? Could the dinosaurs have survived the asteroid that wiped them out? Is it possible to clone a dinosaur? Turn the pages to find the answers to these questions and many more.

Comprehensive yet portable, this concise field-guide edition of Australian Bird Guide is an essential companion for every birdwatcher visiting Australia This new, fully updated concise edition of the award-winning Australian Bird Guide brings the authority and clarity of ABG into a portable format ideal for field use. Its compact format features more than 700 bird species that are residents of or regular visitors to the Australian mainland and Tasmania, and surrounding seas. Easy to use and beautifully illustrated, the book's content has been carefully designed to provide the reader with key information to enable rapid identification of any bird. Australian Bird Guide: Concise Edition includes up-to-date species descriptions, distribution maps, illustrations and comparison pages for major groups. Portable and pocket-friendly yet comprehensive and authoritative, it's an essential companion for any birdwatcher visiting Australia.

"Cell niches" are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells' behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites. Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood-brain/BBB and blood-retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential. The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured.

Targeted Protein Degradation, Volume 680 in the Methods in Enzymology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of timely topics, with each. Each written by an international board of authors.

Advances in Genetics, Volume 108 provides the latest information on genetics, presenting new medical breakthroughs that are occurring as a result of advances in our knowledge of the topic. The book continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, with this new release including chapters on Clinical applications of cancer genetics and genomics, Epigenetic mutations in childhood tumors- the paradigm of Wilms tumor, Preventive population genomics-the model of BRCA related cancers, Recent advances of PARP inhibitors in medical oncology, Role of single cell and liquid biopsy in cancer research and clinical applications. Other chapters cover Recent advances and clinical utility of prostate cancer genomics, Recent advances in lung cancer genomics- applications in targeted therapy, and more.

Advances in Aggregation Induced Emission Materials in Biosensing and Imaging for Biomedical Applications - Part A Volume 184, highlights many aspects of AIE materials that can help future investigators, researchers, students and stakeholders perform research with ease. Emitting light is a fascinating photophysical phenomenon, its different forms have brought the attention of various disciplines of natural sciences for centuries. In the modern era of scientific generation, short-lived fluorescence light and its long-lived counterpart phosphorescence light has been employed for several chemo-sensing, bio-sensing, and bioimaging applications. The aggregation induced emission (AIE) phenomenon has appeared as a wand of modern science to convert aggregation-caused quenching (ACQ) materials into AIE active materials for a wide range of biomedical applications including biosensing, bioimaging and localization of molecules for better understanding of molecular mechanisms. This volume covers a wide range of topics which are not currently available in a single volume, including ACQ & AIE concept development; intracellular pH, temperature and viscosity sensing; imaging of cell membrane, lipid droplet, lysosome, and mitochondria; biosensing and Imaging of bacteria; nucleus and nucleic acid imaging.