Unlike most natural colours that are based on pigment absorption, the striking iridescent and intense colouration of many butterflies, birds or beetles stems from the interaction of light with periodic sub-micrometer surface or volume patterns, so called "photonic structures". These "structural colours" are increasingly well understood, but they are difficult to create artificially and exploit technologically. In this thesis the field of natural structural colours and biomimetic photonic structures is covered in a wide scope, ranging from plant photonics to theoretical optics. It demonstrates diffractive elements on the petal surfaces of many flowering plant species; these form the basis for the study of the role of structural colours in pollinator attraction. Self-assembly techniques, combined with scale able nanofabrication methods, were used to create complex artificial photonic structures inspired by those found in nature. In particular, the colour effect of a Papilio butterfly was mimicked and, by variation of its design motive, enhanced. All photonic effects described here are underpinned by state-of-the-art model calculations.

The book is divided in 4 parts. In the first one, the importance of the analysis of the cardiac dynamics using the ambulatory monitoring technique is presented. The second part contains the description of foundations of impedance cardiography (ICG), the models used to describe the ICG technique and the description of available systems for ambulatory monitoring of cardiac hemodynamics. The third part is devoted to the validation of the ambulatory ICG method, the verification of the quality of long term ICG recordings and the discussion of the limitations of this technique. In the last part, some clinical and research applications of the ICG ambulatory monitoring are presented. The simultaneous recordings of electrocardiogram (ECG) and ICG in the transient cardiac arrhythmia events illustrate the potential applications of that method for quantitative analysis of hemodynamics when the implementation of the stationary methods would be either difficult or not possible to do. The book is followed by references, alphabetical index and appendices containing the technical data of the available systems for portable monitoring of cardiac hemodynamics.

It is now over 30 years since the idea of ion-conducting pores burst on the elec- trophysiological scene, 15 years since these were generalIy realized to be mem- brane-spanning proteins, and 10 years since the first observations of single ion channels from higher organisms were made. During the past 5 years, several integral membrane channel proteins have been purified in a functionalIy competent state: the nicotinic acetylcholine receptor, the Na + channel, mitochondrial "VDAC," and a variety of porins. The stage is thus set to attack ion channels in the same ways that biochemists have been attacking enzymes for decades: isolation folIowed by functional analysis in as simple a system as possible, with a view towards understanding the molecular mechanisms ofthe protein's behavior and how this is related to the underlying molecular structure. This is always a daunting task, alI the more so with ion channels because of our still primitive and scanty understanding of channel structures and because of the difficulty in iso- lating functionally active channel proteins. In this volume, which can be considered a biochemically slanted companion to Sakmann and Neher's Single-Channel Recording, I have tried to present a view of the current landscape of ion-channel reconstitution. These chapters illustrate not only the different approaches and techniques of the major practitioners of ion- channel reconstitution but, as importantly, the varied motivations for doing this kind of work.

The International Symposium on Biological Effects of Magnetic and Electrom- netic Fields was held from September 3-4, 1993 at Kyushu University in Fukuoka . Japan . Originally, it was only intended to be an informal gathering of many scientists who had accepted my invitation to visit Kyushu University after the XXIVth General Assembly of the International Union of Radio Science (URSI), held in Kyoto prior to our symposium . However, since so many distinguished scientists were able to come, it was decided that a more formal symposium would be possible . It was a very productive symposium and, as a result, many of the guests consented that it would be a good idea to gather all the information put forth at the meeting and have it published. In addition, although they were unfortunately unable to attend the symposium . many other distinguished scientists had also expressed their wish to contribute to this effort and, in so doing. help to increase understanding in this, as yet, relatively immature field of science . The question of both positive and negative effects of magnetic and electromagnetic fields on biological systems has become more and more important in our world today as they .

This book deals with the theory and the applications of a new time domain, termed natural time domain, that has been forwarded by the authors almost a decade ago (P.A. Varotsos, N.V. Sarlis and E.S. Skordas, Practica of Athens Academy 76, 294-321, 2001; Physical Review E 66, 011902, 2002). In particular, it has been found that novel dynamical features hidden behind time series in complex systems can emerge upon analyzing them in this new time domain, which conforms to the desire to reduce uncertainty and extract signal information as much as possible. The analysis in natural time enables the study of the dynamical evolution of a complex system and identifies when the system enters a critical stage. Hence, natural time plays a key role in predicting impending catastrophic events in general. Relevant examples of data analysis in this new time domain have been published during the last decade in a large variety of fields, e.g., Earth Sciences, Biology and Physics. The book explains in detail a series of such examples including the identification of the sudden cardiac death risk in Cardiology, the recognition of electric signals that precede earthquakes, the determination of the time of an impending major mainshock in Seismology, and the analysis of the avalanches of the penetration of magnetic flux into thin films of type II superconductors in Condensed Matter Physics. In general, this book is concerned with the time-series analysis of signals emitted from complex systems by means of the new time domain and provides advanced students and research workers in diverse fields with a sound grounding in the fundamentals of current research work on detecting (long-range) correlations in complex time series. Furthermore, the modern techniques of Statistical Physics in time series analysis, for example Hurst analysis, the detrended fluctuation analysis, the wavelet transform etc., are presented along with their advantages when natural time domain is employed.

Humanhairisananocompositebiological?ber. Maintainingthehealth,feel,shine, color,softness,andoverallaestheticsofthehairishighlydesired. Haircarepr- ucts such as shampoos and conditioners, along with damaging processes such as chemical dyeing and permanent wave treatments, affect the maintenance and groomingprocessandareimportanttostudybecausetheyaltermanyhairprop- ties. Nanoscalecharacterizationofthecellularstructure,mechanicalproperties,and morphological, frictional,andadhesive properties(tribologicalproperties)ofhair areessentialtoevaluateanddevelopbettercosmeticproductsandtoadvancethe understandingofbiologicalandcosmeticscience. Theatomic/frictionforcemic- scope(AFM/FFM)andnanoindenterhavebecomeimportanttoolsforstudyingthe micro/nanoscalepropertiesofhumanhair. Inthisbook,wepresentacomprehensive review of structural, nanomechanical, and nanotribological properties of various hairandskinasafunctionofethnicity,damage,conditioningtreatment,andvarious environments. Variouscellularstructuresofhumanhairand?nesublamellarstr- turesofthecuticleareidenti?edandstudied. Nanomechanicalpropertiessuchas hardness,elasticmodulus,tensiledeformation,fatigue,creep,andscratchresistance arediscussed. Nanotribologicalpropertiessuchasroughness,friction,andadhesion are presented, as well as investigations of conditioner distribution, thickness, and bindinginteractions. Tounderstandtheelectrostaticchargebuilduponhair,surface potentialstudiesarealsopresented. Thebookshouldserveasareferencebookonthebiophysicsofhumanhairand hairtreatments. TheresearchreportedinthisbookwassupportedbyProcter&GambleCo. in Cincinnati,Ohio,andKobe,Japan. IwouldliketothankCarmenLaTorrewhohad assistedinvariouspublicationsonhairresearch. Iwouldalsoliketothankmywife Sudha,whohasbeenforbearingduringthepreparationofthisbook. Powell,OH BharatBhushan November2010 v Contents 1 Introduction-Human Hair, Skin, and Hair Care Products...1 1. 1 HumanHair ...1 1. 1. 1 TheCuticle ...3 1. 1. 2 TheCortexandMedulla...6 1. 2 Skin...7 1. 3 HairCare:CleaningandConditioningTreatments,andDamaging Processes ...10 1. 3. 1 CleaningandConditioningTreatments:Shampoo andConditioner...13 1. 3. 2 DamagingProcesses...18 1. 4 OrganizationoftheBook ...19 2 Experimental Methods...21 2. 1 ExperimentalApparatuses...23 2. 2 ExperimentalProcedure ...26 2. 2. 1 StructuralCharacterizationUsinganAFM...26 2. 2. 2 SurfacePotentialStudiesUsingAFM-Based KelvinProbeMicroscopy...29 2. 2. 3 NanomechanicalCharacterizationUsingNanoindentation ...30 2. 2. 4 InSituTensileDeformationCharacterizationUsingAFM ...32 2. 2. 5 Macroscale Tribological Characterization UsingaFrictionTestApparatus...33 2. 2. 6 Micro/nanotribologicalCharacterizationUsinganAFM...35 2. 3 HairandSkinSamples ...41 3 Structural Characterization Using an AFM ...45 3. 1 StructureofHairCrossSectionandLongitudinalSection ...45 3. 1. 1 CrossSectionofHair...45 3. 1. 2 LongitudinalSectionofHair...45 3. 2 StructureofVariousCuticleLayers...48 3. 2. 1 VirginHair...48 vii viii Contents 3. 2. 2 ChemicallyDamagedHair...50 3. 2. 3 Conditioner-TreatedHair...52 3. 2. 4 EffectofHumidityonMorphologyandCellularStructure ofHairSurface...54 3. 3 Summary...55 4 Nanomechanical Characterization Using Nanoindentation, Nanoscratch, and AFM...57 4. 1 Hardness,Young'sModulus,andCreep...

Replacement of a failing hip joint or other defective organs in the human body by artificial 'spare parts' has significantly improved our quality of life. These spare parts have to meet a wide spectrum of mechanical, chemical and design requirements. In this book, the properties and selection of materials for such `spare parts' are deduced from case studies at the start of each chapter. Hard tissue replacements (joints, long bones, dental), soft tissue (heart valves) and tissue engineering are included. The chapters also detail the three generic classes of materials: alloys (including shape memory alloys), ceramics & glasses and polymers. Separate chapters are devoted to the toxicity of implants, the metals zirconium(-zirconium oxide), tantalum, niobium and metallic glasses, soluble metals and Rapid Prototyping techniques for the fabrication of custom made prostheses. The book concludes by a chapter on water as water is always 'there' and conditions the interaction between body and implant. Water is the very matrix of life on earth. A peculiarity of the book is its 'perspective view', meaning that the authors looked behind the present biomaterials' decor and included historical backgrounds (real and mythological), future developments, and the relation to nature (plants and geology).

Defined as, "The science about the development of an embryo from the fertilization of the ovum to the fetus stage," embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a "development cell." That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

Biochemistry of Scandium and Yttrium gathers together existing knowledge about scandium and yttrium from a wide variety of disciplines. Part 1 will present a comparative study of the physical and chemical properties of scandium and yttrium, looking at both their similarities and their differences. (Part 2 will address the biochemical aspects of these two elements, and the various medical and environmental applications.) While these elements are relatively rare in nature, these books will show that they have unusual physical and chemical properties, and a disproportionate number of important applications. Improved analytical techniques have revealed that scandium and yttrium are present throughout living matter, even though only a relatively limited number of species have been analyzed so far. This fact of course has far-ranging implications for biological and environmental concerns. Part 1 also contains a discussion of the interactions of scandium and yttrium with molecules of biological interest, such as organic acids, carbohydrates, proteins, nucleotides, and other biologically active molecules. The major impacts of scandium and yttrium in science, technology, and medicine will be of interest to a wide variety of researchers, including geochemists, inorganic and organic chemists, clinical biochemists, and those specializing in environmental protection. Biochemistry of Scandium and Yttrium, Part 1 and Part 2 will be especially welcome because the last book published on the biochemistry of scandium appeared over 20 years ago, and the only book mentioning the biochemistry of yttrium came out in 1990.

Opening Remarks of the President, 2nd ISVO, Professor G.M. Breinin, M.D. The study of visual processes is surely unique as a clinical specialty, in corporating the disciplines of physics, chemistry, physiology, and psycho logy. Diagnosing and correcting disorders of the visual system in these last two decades of the 20th century has brought all of us into close prox imity with computer sciences, laser technology, the marvels of electronic microcircuitry, and the impressive developments in optical materials. Dur ing the course of this meeting we shall be hearing about how these different technologies can interact with one another, and we shall discover that such interaction may produce new diagnostic tools and new optical devices. We shall also learn that the optical qualities of the eye change during life, producing subtle and complex alterations in vision. On behalf of the members and organizing committee of the American Commit tee on Optics and Visual Physiology and our co-sponsoring organization, the Optical Society of America, I welcome you to this second symposium on visual optics. The first symposium took place in Japan in 1978 and, like the pres ent one, was a satellite meeting of the International Congress of Ophthal mology. The third symposium in this series will take place in Italy in 1986 as part of the next session of the International Congress of Ophthalmology.

This book aims to cover the knowledge of protein folding accumulated from studies of disulfide-containing proteins, including methodologies, folding pathways, and folding mechanism of numerous extensively characterized disulfide proteins. Folding of Disulfide Proteins will be valuable supplementary reading for general biochemistry, biophysics, molecular biology, and cellular biology courses for graduate and undergraduate students. This book can also be used for specialized graduate-level biochemistry, biophysics, and molecular biology courses dedicated to protein folding as well as related biological problems and diseases. Will also be of interest to everybody interested in problems related to protein folding, and anyone who is interested in understanding the mechanism of protein misfolding and protein misfolding-related diseases.

Regeneration, i.e. the replacement of lost body parts by new outgrowths or by remodelling existing tissues, has been studied for centuries. However, in recent years important developments took place in this field too, owing to new soph isticated techniques and to novel theoretical concepts. Advances in Molecular Genetics, Biochemistry, Cell and Neurobiology, Immunology, to mention a few of them, are the main causes of this resurgence of interest in regeneration. As a consequence, more and more meetings and pUblications are devoted, either exclusively or for a large part, to basic and applied research of regenerative processes. "Regeneration ists" scattered in laboratories allover the world and accus tomed to know each other through exchange of reprints - occa sionally an encounter in a large conference - tend now to form small groups, even societies and to institutionalize their meetings. Although the critical mass of scientists involved in regeneration research does not seem yet to be reached, for an autonomous development of this sector, regular and frequent meetings of experts appear useful, even necessary. Such a meeting was convened in Saronis, near Athens, Greece, from 19 to 23 September 1988 and sponsored by the NATO Science Committee and the University of Athens. The present volume contains the contributions to this Advanced Research Workshop on "Recent Trends in Regeneration Research". About 50 biologists from different countries, either mem bers of the Alliance or outside it (U.R.S.S., India, Egypt, Switzerland, Sweden) took part, mostly as invited speakers.

An International Symposium on Low Vision was sponsored by the Centre for Sight Enhancement of the School of Optometry, University of Waterloo in June 1986, bringing low vision researchers and clinicians together from a number of countries. The unique feature of the conference is the multi-disciplinary approach towards low vision care. A total of 44 papers were presented in the three day period by speakers of note from the fields of optometry, ophthalmology, psychophysics, special education, nursing and vision rehabilitation. The papers deal with issues in diagnostic science, low vision assessment and rehabilitation. The proceedings volume is ideal for clinicians and vision scientists to update their understanding of low vision research and clinical practice.

The concept for Vasopressin: Principles and Properties originated during the sum mer of 1983. From reviewing the rich and diverse literature on vasopressin, it became evident that the rapid advancements in this field made it difficult to syn thesize the information gathered from divergent scientific disciplines into a coherent view of the biological role of vasopressin. We perceived the need for a series of critical reviews delineating this recent progress. Over the past decade, major advances have been made in studies of the anatomy, physiology, phar macology, molecular biology, and behavioral activities of vasopressin. This is, in no small measure, due to the finding that vasopressin can no longer be regarded solely as a neurohypophysial hormone. Our present knowledge is that vasopressin is synthesized in also has an axonal messenger role in the nervous system and of the brain, although the functions of vasopressin in these periph sites outside of vasopressin eral sites are not well understood. In order to prepare an overview concentrating on recent studies in vertebrates, authors were selected based on their expertise and asked to review their research area, including the work from other laboratories. It was our intent to provide an updated definitive reference which would complement and extend such past texts as Neurohypophysial Hor mones and Similar Polypeptides (Handbook of Experimental Pharmacology, Vol ume XXIII, 1968) and The Pituitary Gland and Its Neuroendocrine Control (Handbook of Physiology, Section 7: Volume IV, 1974)."

Vortex Formation in the Cardiovascular System will recapitulate the current knowledge about the vortex formation in the cardiovascular system, from mechanics to cardiology. This can facilitate the interaction between basic scientists and clinicians on the topic of the circulatory system. The book begins with a synopsis of the fundamentals aspects of fluid mechanics to give the reader the essential background to address the proceeding chapters. Then the fundamental elements of vortex dynamics will be discussed, explaining the conditions for their formation and the rules governing their dynamics. The main equations are accompanied by mathematical models. Cardiovascular vortex formation is first analyzed in physiological, healthy conditions in the heart chambers and in the large arterial vessels. The analysis is initially presented with an intuitive appeal grounded on the physical phenomena and a focus on its clinical significance.In the proceeding chapters, the knowledge gained from either clinical or basic science literature will be discussed. The corresponding mathematical elements will finally be presented to ensure the adequate diligence. The proceeding chapters ensue to the analysis of pathological conditions, when the reader may have developed the ability to recognize normal from abnormal vortex formation phenomenon. Pathological vortex formation represents vortices that develop at sites where normally laminar flow should exist, e.g. stenosis and aneurisms. This analysis naturally leads to the interaction of vortices due to the surgical procedures with respect to prediction of changes in vortex formation. The existing techniques, from medical imaging to numerical simulations, to explore vortex flows in the cardiovascular systems will also be described. The presentations are accompanied by the mathematical definitions can that be understandable for reader without the advanced mathematical background, while an interested reader with more advanced knowledge in mathematics can be referred to references for further quantitative analyses. The book pursues the objective to transfer the fundamental vortex formation phenomena with application to the cardiovascular system to the reader. This book will be a valuable support for physicians in the evaluation of vortex influence on diagnosis and therapeutic choices. At the same time, the book will provide the rigorous information for research scientists, either from medicine and mechanics, working on the cardiovascular circulation incurring with the physics of vortex dynamics.

This book is the compilation of papers presented at the International Symposium on In Vivo Body Composition Studies, held in Houston, Texas, November 10-12, 1992. The purpose of this conference was to report on the state-of-the-art techniques for in vivo body composition measurements and to present the most recent human data on normal body composition and changes during disease. This conference was the third in a series of meetings on body composition studies held in North America, and follows the successful meetings at Brookhaven National Laboratory in 1986, and the one in Toronto in 1989. A large number of excellent research papers were offered for consideration at this Conference which demonstrates the rapid growth of the field in the last three years. However, we had to limit the presentations to approximately 90 papers which provided a broad spectrum of the applications and recent interest in the subject. The proceedings of the Brookhaven meeting "In Vivo Body Composition Studies," is published by The Institute of Physical Sciences in Medicine, London. The proceedings of the Toronto meeting "In Vivo Body Composition Studies" was published by Plenum Press in its basic life science series. Both these meetings placed more emphasis on technical aspects while the current Houston meeting tried to emphasize more the emerging clinical applications of these techniques. The general sessions used at the Conference for presentations forms the basis of the order of appearance of the papers in this book.

This new volume in the Poincare Seminar Series, describing recent developments at the interface between physics and biology, is directed towards a broad audience of physicists, biologists, and mathematicians. Both the theoretical and experimental aspects are covered, and particular care is devoted to the pedagogical nature of the presentations. The first survey article, by Jean-Francois Joanny and Jacques Prost, describes the theoretical advances made in the study of "active gels," with applications to liquid crystals and cell motility. Jasper van der Gucht and Cecile Sykes then report on recent advances made with biomimetic model systems in the understanding of cytokinesis. The next article, by Jonathon Howard, presents several molecular models for motor proteins, which are compared with experimental results for kinesin. David Lacoste and Kirone Mallick then show theoretically that similar ratchet models of motor proteins naturally satisfy a fundamental time-reversal symmetry, the Gallavotti-Cohen fluctuation relation. Jean-Francois Allemand, David Bensimon and Vincent Croquette and their coauthors describe the latest advances made in the real-time single molecule study of the enzymes involved in DNA replication. Raymond E. Goldstein addresses the problem of understanding, from a physics perspective, the driving forces behind the biological evolution of multicellularity, using Volvocine algae as model organisms. Stanislas Dehaene finally addresses the major challenge of understanding the neuronal mechanism of consciousness, and speculates on the possible theoretical explanations of MRI experiments.

This book is an edited volume, the goal of which is to provide an overview of the current state-of-the-art in statistical methods applied to problems in structural bioinformatics (and in particular protein structure prediction, simulation, experimental structure determination and analysis). It focuses on statistical methods that have a clear interpretation in the framework of statistical physics, rather than ad hoc, black box methods based on neural networks or support vector machines. In addition, the emphasis is on methods that deal with biomolecular structure in atomic detail. The book is highly accessible, and only assumes background knowledge on protein structure, with a minimum of mathematical knowledge. Therefore, the book includes introductory chapters that contain a solid introduction to key topics such as Bayesian statistics and concepts in machine learning and statistical physics.

Digital radiography is a general term describing any projection radiological system in which the image exists in digital form at some stage between acquisition and viewing. In an earlier form, radiographic films were dig itized in an attempt to enhance and redisplay information of interest. The field has evolved to its current state, in which X-ray signals are detected electronically, converted to digital form, and processed prior to being recorded and displayed. A primary goal of digital radiography is the re moval of interfering effects from secondary structures in an image, so that clinically significant details can be displayed with enhanced visibility. The achievement of this goal involves many parameters, including con trast agents, subtraction techniques, processing techniques, filtering tech niques, system noise, and quantitative aspects. It is the purpose of this book to present material by noted individuals in the field covering several of the above topics. The authors acknowledge the secretarial and editorial assistance of Mrs. Helen Taylor and the editorial assistance of Mrs. Ruth McDevitt. James G. Kereiakes Stephen R. Thomas Cincinnati, Ohio Colin G. Orton Detroit, Michigan ix Contents 1. DIGITAL RADIOGRAPHY: OVERVIEW B. A. Arnold, 1. G. Kereiakes, and S. R. Thomas 1. Introduction . . . . . . . . . 1 2. Point-Scanned Detector Systems 3 3. Line-Scanned Detector Systems 4 4. Area Detector Systems 5 4.1. Stimulable Phosphors 5 4.2. Selenium Detectors ."

From time to time, perhaps a few times each century, a revolution occurs that questions some of our basic beliefs and sweeps across otherwise well guarded disciplinary boundaries. These are the periods when science is fun, when new paradigms have to be formulated, and when young scientists can do serious work without first having to acquire all the knowledge of their teachers. The emergence of nonlinear science appears to be one such revolution. In a surprising manner, this new science has disclosed a number of misconceptions in our traditional understanding of determinism. In particular, it has been shown that the notion of predictability, according to which the trajectory of a system can be precisely determined if one knows the equations of motion and the initial conditions, is related to textbook examples of simple; integrable systems. This predictability does not extend to nonlinear, conservative systems in general. Dissipative systems can also show unpredictability, provided that the motion is sustained by externally supplied energy and/or resources. These discoveries, and the associated discovery that even relatively simple nonlinear systems can show extremely complex behavior, have brought about an unprecedented feeling of common interest among scientists from many different disciplines. During the last decade or two we have come to understand that there are universal routes to chaos, we have learned about stretching and folding, and we have discovered the beautiful fractal geometry underlying chaotic attractors.

The Progress in Medical Radiation Physics series presents in-depth reviews of many of the significant developments resulting from the application of physics to medicine. This series is intended to span the gap between research papers published in scientific journals, which tend to lack details, and complete textbooks or theses, which are usually far more detailed than necessary to provide a working knowledge of the subject. Each chapter in this series is designed to provide just enough information to enable readers to both fully understand the development described and apply the technique or concept, if they so desire. Thorough references are provided for those who wish to consider the original literature. In this way, it is hoped that the Progress in Medical Radiation Physics series will be a catalyst encouraging medical physicists to apply new techniques and developments in their daily practice. Colin G. Orton ix Contents 1-1. The Tracking Cobalt Project: From Moving-Beam Therapy to Three-Dimensional Programmed Irradiation W. A. Jennings 1. Introduction 2. Establishing Moving-Beam Techniques at the Royal Northern Hospital, 1945-1955 4 2.1. Alternative Moving-Beam Techniques 4 2.2.

"The Application of Biofluid Mechanics: Boundary Effects on Phoretic Motions of Colloidal Spheres" focuses on the phoretic motion behavior of various micron- to nanometer-size particles. The content of this book is divided into two parts: one on the concentration gradient-driven diffusiophoresis and osmophoresis, and one on thermocapillary motion and thermophoretic motion driven by temperature gradient. Diffusiophoresis and osmophoresis are mainly used in biomedical engineering applications, such as drug delivery, purification, and the description of the behavior of the immune system; thermocapillary motion and thermophoretic motion are applied in the field of semiconductors as well as in suspended impurities removal. The book also provides a variety of computer programming source codes compiled using Fortran for researchers' future applications.

This book is intended for chemical engineers, biomedical engineers and scientists, biophysicists and fundamental chemotaxis researchers. Dr. Po-Yuan Chen is an Assistant Professor at the Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

In Vivo EPR (ESR) is a textbook on this relatively new subject in biomedical electron spin resonance. While a few chapters have appeared in special topics volumes in this series, this book covers the principles and theory, instrumentation as well as the latest applications at the time of its writing. The authors are world-renowned experts and pioneers in their fields. This book is divided into two major sections dealing with theory and instrumentation, and aspects of biochemistry, in vitro and in vivo applications. A significant amount of detail is devoted to clinical applications and the problems and pitfalls encountered in in vivo spectroscopy and imaging.
Key Features:

-History of In Vivo EPR,
-Principles of Imaging-Theory and Instrumentation,
-Time-domain Radio Frequency EPR Imaging,
-The Measurement of Oxygen In Vivo Using In Vivo EPR Techniques,
-Potential Medical (Clinical) Applications of EPR,
-Combining NMR and EPR/ESR for In Vivo Experiments.