Membrane techniques are an excellent alternative to traditional methods of purification and separation. This book covers issues related to the most recent developments in the field of membrane techniques. The latest scientific research and their potential applications in industrial solutions are described. In addition, currents trends in food & beverages technologies, and biomedicine are discussed. Moreover, the book emphasizes recent advancements in design of membrane systems, used either for separation or creation of mixtures, from the perspective of industry 4.0 and data management.

This book explains the principles of biosignal processing and its practical applications using MATLAB. Topics include the emergence of biosignals, electrophysiology, analog and digital biosignal processing, signal discretization, electrodes, time and frequency analysis, analog and digital filters, Fourier-transformation, z-transformation, pattern recognition, statistical data analysis, physiological modelling and applications of EEG, ECG, EMG, PCG and PPG signals. Additional scientifi c contributions on motion analysis by guest authors Prof. Dr. J. Subke and B. Schneider as well as classification of PPG signals by Dr. U. Hackstein.

Written to help companies comply with GMP, GLP, and validation requirements imposed by the FDA and regulatory bodies worldwide, Quality Control Training Manual: Comprehensive Training Guide for API, Finished Pharmaceutical and Biotechnologies Laboratories presents cost-effective training courses that cover how to apply advances in the life sciences to produce commercially viable biotech products and services in terms of quality, safety, and efficacy. This book and its accompanying downloadable resources comprise detailed text, summaries, test papers, and answers to test papers, providing an administrative solution for management. Provides the FDA, Health Canada, WHO, and EMEA guidelines directly applicable to pharmaceutical laboratory-related issues Offers generic formats and styles that can be customized to any organization and help management build quality into routine operations to comply with regulatory requirements Contains ready-to-use training courses that supply a good source of training material for experienced and inexperienced practitioners in the biotechnology/biopharmaceutical industries Includes downloadable resources with downloadable training courses that can be adopted and directly customized to a particular organization Supplies ready-to-use test papers that allow end users to record all raw data up to the issuance of the attached certificate The biotechnology/bioscience industries are regulated worldwide to be in compliance with cGMP and GLP principles, with particular focus on safety issues. Each company must create a definite training matrix of its employees. The training procedures in this book enable end users to understand the principles and elements of manufacturing techniques and provide documentation language ranging from the generic to the specific. The training courses on the downloadable resources supply valuable tools for developing training matrices to achieve FDA, Health Canada, EMEA, MHRA UK, WHO, and GLP compliance.

Plant diseases are a serious threat to food production. This unique volume provides the fundamental knowledge and practical use of B.subtilis as a promising biocontrol agent. In order to replace chemical pesticides, one possibility is microbial pesticides using safe microbes. Bacillus subtilis is one of several candidates. Screening of the bacterium, the application of plant tests, clarification of its suppressive mechanism to plant pathogens and engineering aspects of suppressive peptides production are presented here. The author illustrates how B. subtilis is far more advantageous than, for example, Pseudomonas in biocontrol and can be considered as an useful candidate. Features: Bacterium B. subtilis suppresses many plant pathogens and is a biocontrol agent to replace chemical pesticides The book presents the bacterium's suppressive mechanism to plant pathogens, and engineering aspects of suppressive peptides production Biological control of plant disease plays an important role in sustainable agricultural production practices and is expected to replace agricultural chemicals

Concepts in Cereal Chemistry stimulates critical thinking by emphasizing the important concepts related to the science. Written by distinguished researcher and teacher Dr. Finlay MacRitchie, this compact and reader-friendly book focuses mainly on cereal chemistry, but also incorporates relevant theory from the basic sciences, such as physics and genetics.

A Targeted Approach, Rather than an Exhaustive Review

The book discusses milling and some of the sciences that are relevant to wheat dry milling. It explains how to measure the efficiency of the dry milling process and provides explanations for grain hardness variation. The book also looks at the composition and structure of dough and how this determines the performance of a baked aerated product. It then covers dough rheology and some important aspects of processing.

Logically Organized with Exercises at the End of Most Chapters

Next, the book explores cereal shelf life and the well-known phenomenon of bread staling and its underlying causes. Coverage then shifts to proteins and the relationship between cereal composition and functionality. A discussion of strategies to manipulate end-use properties is followed by chapters on non-wheat cereals and health-related aspects of cereals. Suggested solutions to end-of-chapter questions and exercises round out the book s solid coverage. These solutions require critical thinking and, in some cases, searches of the literature. Demonstrations are included to further illustrate principles. This well-organized resource provides students and researchers in both academia and industry with the information they need to tackle problems likely to arise in cereal research.

What role will biofuels play in the scientific portfolio that might bring energy independence and security, revitalize rural infrastructures, and wean us off of our addiction to oil? The shifting energy landscape of the 21st century, with its increased demand for renewable energy technology, poses a worrying challenge. Discussing the multidisciplinary study of bioenergy and its potential for replacing fossil fuels in the coming decades, Introduction to Biofuels provides a roadmap for understanding the broad sweep of technological, sociological, and energy policy issues that intermingle and intertwine.

Copiously illustrated and with numerous examples, this book explores key technologies, including biotechnology, bioprocessing, and genetic reprogramming of microorganisms. The author examines the future of biofuels from a broader perspective, addressing the economic, social, and environmental issues crucial for studying the sustainable development of bioenergy. Each chapter begins with questions and provides the answers later in the chapter as key informational points. Embedded Science, Technology, Engineering, and Math (STEM) sections provide detailed derivations and equations for a subset of topics that can be found easily as buzzwords in popular media and on web sites. Together, the STEM topics form a thread of essential technologies and a guide to how researchers have established quantitative parameters that are crucial to the ever-growing biofuels database.

With so much information scattered throughout the literature, it is often difficult to make sense of what is real and what is an optimistic selling of ideas with no scientific credibility. This book does an excellent job of filtering through volumes of data, providing a historical perspective on which to anchor the information, and outlining the strengths and constraints of the different biofuels.

Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Biosensors in Drug Discovery Programs: Microtissue Engineering for High Throughput Screening provides the latest information - from theory to practice - on challenges and opportunities for incorporating 3D cell-based biosensors or assays in drug discovery programs. The book supplies a historical perspective and defines the problem 3D cultures can solve. It also discusses how genomics and combinatorial chemistry have changed the way drug are discovered and presents data from the literature to underscore the less-than-desirable pharmaceutical industry performance under the new paradigm. The author uses results from his lab and those of other investigators to show how 3D micro environments create cell culture models that more closely reflect normal in vivo-like cell morphology and function. He makes a case for validated biomarkers for three-dimensionality in vitro and discusses the advantages and disadvantages of promising tools in the search of these biomarkers. The book concludes with case studies of drugs that were abandoned late in the discovery process, which would have been discarded early if tested with 3D cultures. Dr. Kisaalita presents evidence in support of embracing 3D cell-based systems for widespread use in drug discovery programs. He goes to the root of the issue, establishing the 3D cell-based biosensor physiological relevance by comparing 2D and 3D culture from genomic to functional levels. He then assembles the bioengineering principles behind successful 3D cell-based biosensor systems. Kisaalita also addresses the challenges and opportunities for incorporating 3D cell-based biosensors or cultures in current discovery and pre-clinical development programs. This book makes the case for widespread adoption of 3D cell-based systems, rendering their 2D counterparts, in the words of Dr. Kisaalita "quaint, if not archaic" in the near future.

Biofortification - the enrichment of staple food crops with essential micronutrients - has been heralded as a uniquely sustainable solution to the problem of micronutrient deficiency or 'hidden hunger'. Considerable attention and resources are being directed towards the biofortification of rice - the world's most important food crop. Through an in-depth analysis of international rice biofortification efforts across the US, Philippines and China, this book provides an important critique of such goal-oriented, top-down approaches. These approaches, the author argues, exemplify a model of global, 'public goods' science that is emerging within complex, international research networks. It provides vital lessons for those researching and making decisions about science and research policy, showing that if this model becomes entrenched, it is likely to channel resources towards the search for 'silver bullet' solutions at the expense of more incremental approaches that respond to locality, diversity and the complex and uncertain interactions between people and their environments. The author proposes a series of key changes to institutions and practices that might allow more context-responsive alternatives to emerge. These issues are particularly important now as increasing concerns over food security are leading donors and policy makers to commit to ambitious visions of 'impact at scale' - visions which may never become a reality and may preclude more effective pathways from being pursued. Published in association with the Economic and Social Research Council (ESRC).

This book highlights the nano-antioxidants and their potential therapeutic applications. The chapters start with basic information on free radicals and antioxidants, through natural antioxidants, mechanisms of their action, ending with the use of nano-antioxidants particularly its potential therapeutic applications. Nano-antioxidant therapy has a promising future that has to be explored. It is a bridge topic to connect the already existing literature with potential therapeutic highlights. This book is designated for students and researchers interested in Biochemistry, Chemistry, Physics, Food Science and nutrition, Pharmaceutical Science and Medicine. It would also be interesting to global audiences from human and animal nutrition to food preservation and packaging.

This volume presents the recent developments on the biomedical applications of chitosan and its derivatives. Chitosan exhibits unique properties such as non-toxicity, biodegradability and biocompatibility. Since its chemical structure and properties can be easily modified, it can be an ideal candidate as a biomaterial. Consequently, chitosan and its derivatives are being developed in different forms such as nanoparticles, micelles, nanofibers, hydrogels, films and 3D porous materials for various biomedical applications, ranging from drug and gene delivery to tissue engineering and regenerative medicine. The chapters of this volume focus on the potential use of chitosan and its derivatives as a hemostatic agent, tissue sealants, tissue engineering scaffolds, delivery carriers for bioactive molecules in bone tissue engineering and wound dressings. Some chapter's deal with recent advancements of chitosan-based biomaterials as a drug, gene and transdermal drug delivery carrier. In addition, the volume focusses on the prospects of chitosan-based systems for the treatment of cancer, eye and other infectious diseases. The volume will be of interest to material scientists, chemists and biotechnologists by providing a better understanding of the physicochemical and biological characteristics of chitosan and its derivatives to develop more appropriate and innovative chitosan-based materials modified for unlimited practical applications in biomedical fields.

Energy and feedstock materials for the chemical industry show an increasing demand. With constraints related to availability and use of oil, the energy and chemical industry is subject to considerable changes. The need for the use of cheaper and widely available feedstocks, and the development of sustainable and environmentally friendly chemical processes is growing rapidly under both economical and public pressure. Therefore, waste gas treatment has gradually been integrated into the process design. Instead of discharging their waste gases into the atmosphere, industries increasingly attempt to become self-sufficient and recover compounds from their own wastestreams or use (upgraded) wastestreams of neighbouring industries as raw material. The proceedings of the 3rd International Symposium on Biotechniques for Air Pollution Control, held on 28-30 September 2009 in Delft, the Netherlands, give an overview of innovative biotechnology based processes for treatment of waste gasses. Various innovative research aspects of environmental chemistry, environmental engineering, and bioprocess technology are discussed.

Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS).

Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry.

The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids.

The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.

Transgenic plants present enormous potential to become one of the most cost-effective and safe systems for large-scale production of proteins for industrial, pharmaceutical, veterinary, and agricultural uses. Over the past decade, much progress has been made with respect to the development of vaccines, antibodies, and other therapeutic proteins. Biopharmaceuticals in Plants: Toward the Next Century of Medicine provides a comprehensive survey of all major aspects of the development and production of plant-made biopharmaceuticals.

Accompanied by an exhaustive list of references to facilitate further study, this critical volume:

• Describes the theory and practice of modern plant transformation techniques with respect to nuclear and plastic genomes
• Outlines the steps involved in the generation of transgenic plants
• Discusses the engineering of plant virus expression vectors for transient expression of vaccine proteins and other therapeutics in plant tissue
• Addresses the significant role of glycosylation in the production of plant-made mammalian proteins
• Investigates the basis of mucosal immunity using plant-based oral vaccines
• Examines the scale-up of plant-derived vaccine and therapeutic proteins in entire crops or in large batch cell suspension cultures
• Explores the development of clinical trials utilizing plant-derived biopharmaceutical proteins
• Evaluates risks and biosafety concerns regarding plant-derived pharmaceuticals

The book concludes with a discussion of the future of plant-based vaccines and other therapeutic proteins with respect to commercial viability and as a tool to improve global public health. Far-reaching in its scope, this text is a baseline reference that students and researchers in a broad range of fields such as medicine, plant science, biotechnology, crop science, natural products chemistry, and engineering will consult regularly. It will also serve as a useful tool for individuals and companies seeking to invest in this dynamic area.

Covers the Fundamentals of Chiral Separation, Available Chiral Selectors, and Numerous Applications of Chiral Separation by Capillary Electrophoresis Since the 1980s, modern analytical tools have enabled capillary electrophoresis to become a standard part of the chemist's toolkit. With contributions from international experts, Chiral Separations by Capillary Electrophoresis provides a general overview of the principles of chiral separation by capillary electrophoresis and the different chiral selectors available. The book discusses the most important as well as several new chiral selectors used in capillary electrophoresis. It reviews recent pharmaceutical and biomedical applications and explores novel techniques, such as capillary electrophoresis coupled to mass spectrometry and microchip technology. The book also examines the quantitative aspects of capillary electrophoresis, the possibilities of capillary electrochromatography, and the various chiral columns available. Capillary electrophoresis has proven to be an effective tool for chiral separation. This book explains how this technique can be used in the separation of molecules, offering insight into both existing and emerging applications.

How do we promote global economic development, while simultaneously preserving local biological and cultural diversity? This authoritative volume, written by leading legal experts and biological and social scientists from around the world, aims to address this question in all of its complexity. The first part of the book focuses on biodiversity and examines what we are losing, why and what is to be done. The second part addresses biotechnology and looks at whether it is part of the solution or part of the problem, or perhaps both. The third section examines traditional knowledge, explains what it is and how, if at all, it should be protected. The fourth and final part looks at ethnobotany and bioprospecting and offers practical lessons from the vast and diverse experiences of the contributors.

Cross-talk between plant and microbe Overview of advanced molecular techniques particular to study plant-microbe interaction Practical guide to technologies such as NGS Omics data analysis particular to study plant-microbe interaction Role of Soil Metagenomics Advanced technologies such as Nanotech and CRISPR serving plant-microbe interaction

This edited book brings out a comprehensive collection of information on the modern omics-based research. The main focus of this book is to educate researchers about utility of omics-based technologies in rapid crop improvement. In last two decades, omics technologies have been utilized significantly in the area of plant sciences and has shown promising results. Omics technology has potential to address the challenge of food security in the near future. The comprehensive use of omics technology occurred in last two decades and helped greatly in the understanding of complex biological problems, improve crop productivity and ensure sustainable use of ecosystem services. This book is of interest to researchers and students of life sciences, biotechnology, plant biotechnology, agriculture, forestry, and environmental sciences. It is also a useful knowledge resource for national and international agricultural scientists.

This book aims to structure, in a complete and sequential way, the mainstream technical knowledge which is related to eutrophication control. The book considers the development of innovative technologies for phosphate removal, while supporting the restoration of currently degraded lakes and reservoir systems. In addition, this book contains key-aspects of future benchmark interests being specially framed under the ongoing development of a circular economy. In particular, the book will contribute to a better understanding of the problem of internal P-loads and P-sources disposition towards a more effective control of nutrients' enrichment in lakes. The chemical routes and environmental fate of such lake nutrients will be viewed in the light of innovative technologies (engineering dimensions) and circular economy perspectives (economics dimensions). The main theme extends to an economic appreciation of environmental polluted aquifers. The book will appeal to an interdisciplinary audience, covering a wide spectrum of scientific fields, such as environment, physical chemistry, surface chemistry, interfacial phenomena, coastal engineering, bio-engineering, environmental policy makers, and economists.

This book summarizes experimentally-supported research on the therapeutic efficacy of plant extracts and their constituents on a range of respiratory diseases including infections. It discusses the pharmacological, cellular and molecular factors involved in the pathogenies of respiratory diseases and their modulation by plant-derived compounds. Additionally, it underlines the growing relevance of medicinal plant-based advanced drug delivery systems for treating lung diseases providing maximal therapeutic efficacy with better patient compliance. Overall, this comprehensive book is a blend of translational, biological, chemical and drug delivery aspects of medicinal plants employed in targeting respiratory diseases and attracts a range of audiences including physiochemist, translational and clinical researchers working in the field of respiratory diseases.