The author offers an overview of pollen biology and biotechnology for students and researchers in areas such as reproductive biology, biotechnology, aeropalynology, plant breeding, horticulture, and forestry. Citing more than 1,500 references to pollen research, the text covers topics including advances in understanding pollen tube growth, the use of pollen for gene transfer, and advantages and disadvantages of various pollination systems for production of species limits.

Introductory text for students of genetics is general and the students of agronomy as the book gives numerous agronomic applications.

Half of the 12 papers are research reports selected from the presentations to an international conference at Manonmaniam Sundaranar University on an undisclosed date. The others are reviews of literature on the same theme of advanced technologies in fisheries and marine sciences. Among the topics are gene transfer to germline and somatic tissues of

Biogenetic resources - the critical biological and chemical materials that underpin so much of medicine, both modern and traditional, agriculture, and wider economic activity in so many fields - are at the centre of heated debate regarding their use, development, and ownership, and the issues of ethics and equity that impinge on all of these factors. This book is a comprehensive examination of the key issues, institutions and ideologies in this area, presenting definitions and explanations of the fundamentals of intellectual property rights (IPRs), biogenetic resources and traditional knowledge. It uses the insights from this to build a picture of how these factors interact in practice, bringing to the surface issues such as: the conservation and sustainable use of biodiversity, benefit sharing from the commercial use of biodiversity, biotechnological innovation and the transfer of technology, agriculture, food security, rural development, health and international justice. Part 1 describes the relevant international IPR laws, highlights the extent to which modern commerce depends on such resources, and traces the way in which modern IPR law has evolved to accommodate this dependence. Part 2 shows how stronger IPR protection in the area of life science innovation has given rise to controversies such as 'biopiracy', 'terminator' genes and genetic uniformity. Part 3 focuses on traditional knowledge, its nature, its importance, and the applicability of IPR-style protection. Part 4 covers the international negotiation and policy-making of the WTO, WIPO and CBD and the legislative initiatives of national governments of Asia, Africa and Latin America. Finally, Part 5 focuses on two developing country case studies - of India and Kenya - assessing whether they will be able to gain economic benefit from development of their natural resources within the current regulatory system and whether this will encourage the conservation and sustainable use of the resource base. With its multidisciplinary approach and breadth of coverage, this book will appeal both to those new to the subject and to those with professional and specialist interest, including students, academics, legal practitioners, government policy-makers and the private sector.

Polysaccharides and related high molecular weight glycans are hugely diverse with wide application in Biotechnology and great opportunities for further exploitation. An Introduction to Polysaccharide Biotechnology - a second edition of the popular original text by Tombs and Harding - introduces students, researchers, clinicians and industrialists to the properties of some of the key materials involved, how these are applied, some of the economic factors concerning their production and how they are characterized for regulatory purposes.

Advances in Macrofungi: Diversity, Ecology and Biotechnology discusses the diversity and ecology of edible, toxic, medicinal and mycorrhizal macrofungi; the impact of ectomycorrhizal fungi in terrestrial ecosystems, ectomycorrhizal complex in Boreal forests and commercial application of Pseudotsuga in silviculture; the nutritional evaluation and cultivation of edible wild mushrooms; the diversity of novel metabolites of macrofungi useful in food, pharmaceutical and cosmeceutical industries; mushrooms as tool for eco-friendly synthesis of nanoparticles and proteomics of edible and medicinal mushrooms. In addition, it covers experimental designs, methodological approaches, biogeochemical cycles, conceptual/hypothetical models and life history strategies, linking mycorrhizal diversity to plant performance, chemotaxonomy, role of mycorrhizae in forestry and macrofungi in nanotechnology. It provides a valuable resource to graduate, post-graduate and researchers (in botany, microbiology, ecology, biotechnology, forestry, life sciences and environmental sciences) to understand the diversity, ecology, therapeutic value, mutualistic associations and biotechnological potential of macrofungi.

Contents:
Chapter 1: Introduction
1. The Approach
2. National Innovation Systems and Biotechnology
3. The Market for Biotechnology
4. Products
5. A Road Map
6. References
Chapter 2: Firms, Technological Regimes, and National Innovation Systems
1. Introduction
2. The Firm as Innovator
3. Technological Regimes and Trajectories
4. Biotechnology and the National Innovation System
5. Putting it all Together
6. References
Chapter 3: Biotechnology and National Innovation Systems in the US and Japan
1. Industry
2. Research Infrastructure
3. Public Policy
4. Conclusions
5. References
Chapter 4: The Emergence of Commercial Biotechnology in the US
1. Introduction
2. Institutional Formation and Knowledge Creation
3. Knowledge Enhancement (1976-1983)
4. Commercial Take-Off (1983-1900s)
5. Conclusions
6. References
Chapter 5: The Emergence of Commercial Biotechnology
1. Introduction
2. The Origins of Japan's Bioindustry
3. Biotechnology Fever hits Japan
4. From Bio-Boom to Bio-Reality: Alliances Strategies and the Shift from Basic Research (1985-Present)
5. Conclusions
6. Endnotes
Chapter 6: Conclusions
1. Summary
2. Biotechnology in the US and Japan
3. Concluding Thoughts
References

Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts Cell and Matrix Mechanics presents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell-matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models. Summarizes the Three Hierarchical Levels of Cell Mechanics The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell-matrix mechanics by Albert K. Harris. The topics covered include: The passive and active mechanical properties of cytoskeletal polymers and associated motor proteins along with the behavior of polymer networks The mechanical properties of the cell membrane, with an emphasis on membrane protein activation caused by membrane forces The hierarchical organization of collagen fibrils, revealing that a delicate balance exists between specific and nonspecific interactions to result in a structure with semicrystalline order as well as loose associations The roles of matrix mechanical properties on cell adhesion and function along with different mechanical mechanisms of cell-cell interactions The effects of mechanical loading on cell cytoskeletal remodeling, summarizing various modeling approaches that explain possible mechanisms regulating the alignment of actin stress fibers in response to stretching The mechanical testing of cell-populated collagen matrices, along with theory relating the passive and active mechanical properties of the engineered tissues Cell migration behavior in 3-D matrices and in collective cell motility The role of mechanics in cartilage development The roles of both cellular and external forces on tissue morphogenesis The roles of mechanical forces on tumor growth and cancer metastasis Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell-matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.

This volume examines the convergence of biotechnology and communication systems and explores how this convergence directly influences our understanding of the nature of communication. Editor Sandra Braman brings together scholars to examine this convergence in three areas: genetic information and "facticity"; social issues and implications; and the economic and legal issues raised by the production and ownership of information. The work highlights the sophisticated processes taking place as biotechnology and information technology systems continue to evolve. The chapters in this book approach the complex history of this topic and the issues it raises from a number of directions. It begins by examining the shared features and spaces of biotechnology and digital information technologies as meta-technologies--qualitatively distinct from both the tools first used in the premodern era and the industrial technologies that characterized modernity. Next, the book explores what is and is not useful in treating the types of information processed by the two meta-technologies through a shared conceptual lens and looks at issues raised by the ownership of genetic and digital information. The final chapters are concerned with relationships between information and power. Defining a future research agenda for communication scholarship, this work is beneficial to scholars and students in science communication, cultural studies, information technologies, and sociology.

From the laboratory to full-scale commercial production, this reference provides a clear and in-depth analysis of bioreactor design and operation and encompasses critical aspects of the biocatalytic manufacturing process. It clarifies principles in reaction and biochemical engineering, synthetic and biotransformation chemistry, and biocell and enzyme kinetics for successful applications of biocatalysis and bioprocess technologies in the food, chiral drug, vitamin, pharmaceutical, and animal feed industries. Studying reactions from small to supramolecules, this reference provides an abundant supply of end-of-chapter problems to sharpen understanding of key concepts presented in the text.

Practicing engineers will find this text helpful in getting up to date. Readers with some familiarity with this field will be able to follow the presentations with ease. Engineering students and those taking physics courses will find this book to be a useful source of examples of applications of the theory to commercially available materials as well as for uncomplicated explanations of physical properties. In many cases alternate explanations have been provided for clarity.An effort has been made to keep mathematics as an unsophisticated as possible withoutwatering down or distorting the concepts. In practically all cases only a master of elementary calculus is required to follow the derivations. All of thealgebra is shown and no steps in the derivations are considered to be obvious to the reader. Explanations are provided in cases where more advanced mathematics is employed The problems have been designed to promote understanding rather than mathematical or computational skill.

Scientists have developed a featherless chicken designed to make industrial chicken production more efficient, while specially trained Pacific bottlenose dolphins are being deployed in the Persian Gulf to disarm mines and protect our Navy. Everyone knows Darwin's theory of natural selection, but what about his idea of artificial selection-how humans, not nature, rework natural organisms to meet our needs? Industrializing Organisms brings us to the threshold of the new field of evolutionary history-from the mobilization of war horses in the nineteenth century to today's engineered plants and manipulated animals.

The biotechnology industry is an extremely important sector in the developed world's economies. This book, with contributions from an international array of experts, explains why biotechnology companies in different countries concentrate in a small number of locations and what accounts for the success some of these companies then go on to have.
This interesting book covers such themes as:
* the role of small firms in US biotechnology clusters
* geographic clustering in the UK
* case studies involving the sectors in a cross-section of European companies
With such international contributions, this book will be of interest to students and academics involved in Industrial Organization, Innovation Studies and Business Organization. Not only that, professionals with an interest in international business will also find this to be a very useful read.

Concepts in Cereal Chemistry stimulates critical thinking by emphasizing the important concepts related to the science. Written by distinguished researcher and teacher Dr. Finlay MacRitchie, this compact and reader-friendly book focuses mainly on cereal chemistry, but also incorporates relevant theory from the basic sciences, such as physics and genetics. A Targeted Approach, Rather than an Exhaustive Review The book discusses milling and some of the sciences that are relevant to wheat dry milling. It explains how to measure the efficiency of the dry milling process and provides explanations for grain hardness variation. The book also looks at the composition and structure of dough and how this determines the performance of a baked aerated product. It then covers dough rheology and some important aspects of processing. Logically Organized with Exercises at the End of Most Chapters Next, the book explores cereal shelf life and the well-known phenomenon of bread staling and its underlying causes. Coverage then shifts to proteins and the relationship between cereal composition and functionality. A discussion of strategies to manipulate end-use properties is followed by chapters on non-wheat cereals and health-related aspects of cereals. Suggested solutions to end-of-chapter questions and exercises round out the book's solid coverage. These solutions require critical thinking and, in some cases, searches of the literature. Demonstrations are included to further illustrate principles. This well-organized resource provides students and researchers in both academia and industry with the information they need to tackle problems likely to arise in cereal research.

This publication details the isolation of proteins from biological materials, techniques for solid-liquid separation, concentration, crystallization, chromatography, scale-up, process monitoring, product formulation, and regulatory and commercial considerations in protein production. The authors discuss the release of protein from a biological host, selectivity in affinity chromatography, precipitation of proteins (both non-specific and specific), extraction for rapid protein isolation, adsorption as an initial step for the capture of proteins, scale-up and commercial production of recombinant proteins, and process monitoring in downstream processing.

The use of marine organisms to degrade a variety of natural and synthetic substances in the marine environment, thereby reducing the levels of hazardous compounds, is increasingly drawing attention because of the potential such bioremediation has for environmental restoration. Among the current research efforts in bioremediation are some directed towards identifying organisms that possess the ability to degrade specific pollutants. With such organisms, which have already been identified, biochemical studies are going on with the aim of elucidating the pathways of these degradative processes and the enzymes involved. The volume includes chapters that are devoted to petroleum spill bioremediation, use of spectroscopy to identify microbial metabolic pathways, detoxification of mercury by using recombinant mercury-resistant bacteria, and the use of manganese-oxidizing bacteria for bioremediation. A broad-based approach to bioremediation of marine habitats is required because of the wide variety of contaminants in our oceans.

Combining elements of biochemistry, molecular biology, and immunology, artificial DNA can be employed in a number of scientific disciplines. Some of the varied applications include site-specific mutagenesis, hybridization, amplification, protein engineering, anti-sense technology, DNA vaccines, protein vaccines, recombinant antibodies, screening for genetic and pathogenic diseases, development of materials with new biochemical and structural properties, and many more.

Artificial DNA: Methods and Applications introduces the concept of artificial DNA that has been rationally designed and explains how it may be exploited in order to develop products that will achieve your intended purpose. The first part of the book covers methods of oligonucleotide synthesis and direct applications of synthetic DNA. The second part describes methods of gene assembly from synthetic oligonucleotides and applications of synthetic genes. The authors also discuss the different trends and future developments within each application area .

With state-of-the art research, the contributing authors describe how to engineer proteins using rational and semi-rational design to exhibit the desired traits and detail the various amplification reactions and hybridization techniques for modeling evolution and for use in basic research. The only text devoted to this subject, Artificial DNA offers a comprehensive review that allows you to understand the strategy, design, and applications of synthetic oligonucleotides.

This book considered the biological, ecological, toxicology, and chemical aspects of research topics as they relate to endophytes of grasses. Several chapters reflect the very pragmatic applications of endophytes and endophyte-infected grasses. Other chapters offer future applications for endophytes and are therefore discussed from theoretical viewpoints. This book contains the collective writings of an international group of experts on fungal endophytes of grasses, all of whom are directed toward, understanding, creating, and exploiting the positive aspects of endophytes. With this book, we are attempting to stimulate and facilitate future explorations of the grass endophytes.

This text provides a clear exposition of genetic principles and problems with comprehensive, up-to-date references. Specialists who have collaborated closely with industry give an inside authentic view of the genetics and breeding of industrial microorganisms such as yeasts, filamentous fungi, actinomycetes, pseudomonads, and other bacteria of major industrial significance. This book will be especially valuable to many professionals in the field of microbial genetics.

This book presents current and anticipated quantitative values for a wide range of cirtical figures of merit which characterize technological capabilities in the major discipline areas of space technology. The projections are based on historical data and the considered opinions of knowledgable experts in government and industry who are active contributors in their respective fields.

This volume, based on the 1977 NSF Residential Advanced Particle Morphology Workshop, covers the principle developments in this new and rapidly evolving field. The divergent fields of interst of the authors reflect the prosepcts for the wide application of particle morphology analysis and include: many branches of science and engineering concerned with fine particles, information processing, life sciences, pharmacy, and food technology.

Nanotechnology and regenerative engineering have emerged to the forefront as the most versatile and innovative technologies to foster novel therapeutic techniques and strategies of the twenty-first century. The first edition of Nanotechnology and Tissue Engineering: The Scaffold was the first comprehensive source to explain the developments in nanostructured biomaterials for tissue engineering, the relevance of nanostructured materials in tissue regeneration, and the current applications of nanostructured scaffolds for engineering various tissues. This fully revised second edition, renamed Nanotechnology and Regenerative Engineering: The Scaffold, provides a thorough update to the existing material, bringing together these two unique areas to give a perspective of the emerging therapeutic strategies for a wide audience. New coverage includes: Updated discussion of the importance of scaffolds in tissue engineering Exploration of cellular interactions at the nanoscale Complete range of fabrication processes capable of developing nanostructured scaffolds for regenerative engineering Applications of nanostructured scaffolds for neural, skin, cardiovascular, and musculoskeletal regenerative engineering FDA approval process of nanostructure scaffolds Products based on nanostructured scaffolds Due to the unique and tissue-mimic properties of the nanostructured scaffolds, the past five years have seen a tremendous growth in nanostructured materials for biological applications. The revised work presents the current state-of-the-art developments in nanostructured scaffolds for regenerative engineering.

Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Biomaterials and Stem Cells in Regenerative Medicine explores a range of applications for biomaterials and stem cell therapy and describes recent research on suitable cell scaffolds and substrates for tissue repair and reconstruction. Featuring contributions by experts in the field, the book explores important scientific and clinical aspects. It covers the basic science involved in structure and properties, techniques and technological innovations in processing and characterization, and applications of biomaterials and stem cells. Topics include: Polymeric systems for stem cell delivery The potential of membranes and porous scaffolds in tissue repair, including myocardial, periodontal, ophthalmic, and bone tissues The optimization of the interaction between stem cells and biomaterial substrates The source and nature of stem cells for tissue engineering applications The clinical translation of stem cell-based tissue engineering for regenerative medicine From fundamental principles to recent advances at the macro, micro, nano, and molecular scales, the book brings together current knowledge on biomaterials and stem cells in the context of regenerative medicine. It also stimulates discussion about future research directions. This unique book offers a valuable benchmark for the current status of clinically relevant research and development in stem cells and regenerative medicine. It bridges the gaps in experimental approaches and understanding among the materials science and engineering, biological sciences, and biomedical science and engineering communities, making it a valuable reference for graduate students, researchers, and practitioners working in the multidisciplinary field of biomedical research.

In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington's disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington's disease patients and their families.

Support vector machines (SVMs) are used in a range of applications, including drug design, food quality control, metabolic fingerprint analysis, and microarray data-based cancer classification. While most mathematicians are well-versed in the distinctive features and empirical performance of SVMs, many chemists and biologists are not as familiar with what they are and how they work. Presenting a clear bridge between theory and application, Support Vector Machines and Their Application in Chemistry and Biotechnology provides a thorough description of the mechanism of SVMs from the point of view of chemists and biologists, enabling them to solve difficult problems with the help of these powerful tools. Topics discussed include: Background and key elements of support vector machines and applications in chemistry and biotechnology Elements and algorithms of support vector classification (SVC) and support vector regression (SVR) machines, along with discussion of simulated datasets The kernel function for solving nonlinear problems by using a simple linear transformation method Ensemble learning of support vector machines Applications of support vector machines to near-infrared data Support vector machines and quantitative structure-activity/property relationship (QSAR/QSPR) Quality control of traditional Chinese medicine by means of the chromatography fingerprint technique The use of support vector machines in exploring the biological data produced in OMICS study Beneficial for chemical data analysis and the modeling of complex physic-chemical and biological systems, support vector machines show promise in a myriad of areas. This book enables non-mathematicians to understand the potential of SVMs and utilize them in a host of applications.