Mathematical Modelling of Chromosome Replication and Replicative Stress (Hardcover, 2015 ed.)

DNA replication is arguably the most crucial process at work in living cells. It is the mechanism by which organisms pass their genetic information from one generation to the next and life on Earth would be unthinkable without it. Despite the discovery of DNA structure in the 1950s, the mechanism of its replication remains rather elusive. This work makes important contributions to this line of research. In particular, it addresses two key questions in the area of DNA replication: which evolutionary forces drive the positioning of replication origins in the chromosome and how is the spatial organization of replication factories achieved inside the nucleus of a cell?. A cross-disciplinary approach uniting physics and biology is at the heart of this research. Along with experimental support, statistical physics theory produces optimal origin positions and provides a model for replication fork assembly in yeast. Advances made here can potentially further our understanding of disease mechanisms such as the abnormal replication in cancer.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	July 2014
First published:	2015
Authors:	Jens Karschau
Dimensions:	235 x 155 x 6mm (L x W x T)
Format:	Hardcover
Pages:	76
Edition:	2015 ed.
ISBN-13:	978-3-319-08860-0
Categories:	Books > Science & Mathematics > Mathematics > Applied mathematics > General Books > Science & Mathematics > Physics > Thermodynamics & statistical physics > Statistical physics Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Books > Professional & Technical > Biochemical engineering > Biotechnology > Genetic engineering Promotions
LSN:	3-319-08860-2
Barcode:	9783319088600

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