This book provides simple and practical instructions on how to perform safe and easy venous cannulation, and how to insert midlines and PICC lines using ultrasound. It aidsunderstanding of the relevant anatomy, shows how to use the ultrasound machine, and how to insert such lines using ultrasound guidance. Readers will feel confident and well prepared to deal with patients requiring difficult venous access, giving them simple solutions that can be learned very quickly. These skills will also be globally beneficial for patients and healthcare institutions alike. Follows the trends of the NHS and riding the wave of the midline/PICC line revolution Compact and affordable highly relevant to daily practice Useful for specialists and generalists alike, truly multi-disciplinary

Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.

This state-of-the-art reference details current and effective symptom-specific strategies for the diagnosis and management of diabetic patients-emphasizing the exploration of therapeutic options available for the treatment of accelerated coronary complications associated with diabetes. Addresses the pathophysiology underlying advanced heart disease and outlines treatments to impede progression in type 2 diabetic patients. Medical Management of Diabetes and Heart Disease contains the newest discoveries in -the relationship between diabetes and coronary illnesses -type 1 and type 2 diabetes -risk factors in diabetic patients for progressive heart disease -detection and diagnosis of insulin resistance and diabetes mellitus -nonpharmacological treatment and features the latest therapies in the treatment of coronary illnesses in diabetic subjects with -stable and unstable angina -acute myocardial infarction -congestive heart failure -percutaneous coronary intervention -coronary surgery With over 700 references and the contributions of more than 20 world-renowned experts, Medical Management of Diabetes and Heart Disease is an invaluable reference for primary care, family practice, and internal medicine physicians; cardiologists; cardiothoracic surgeons; endocrinologists; physician assistants; nurse practitioners; and medical students in these disciplines.

Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has been recently demonstrated to be an important endogenous molecule of gas that has profound physiological and pathophysiological effects on the cardiovascular system. In spite of the growing understanding achieved in this field, until now a comprehensive book summarizing the extraordinary advances in the research of the cardiovascular effects of CO has not been available. Carbon Monoxide and Cardiovascular Functions responds to the vexing challenges and exciting opportunities that confront researchers and clinicians studying the biological roles of CO in the cardiovascular system. This book presents many never-before-published results including the first case of human CO deficiency. It also discusses disorders where the cardiovascular effects of CO might have been altered, including hypertension, diabetes, stroke, and ischemic heart damage. A product of the collected knowledge of internationally respected scientists, this book serves as a standard reference summarizing recent developments, scientific controversies, and future directions in the study of the biological actions of CO on the cardiovascular system. By covering both ancient and state-of-the-art methodologies in great detail, Carbon Monoxide and Cardiovascular Functions, affords a rapid mastery of the powerful new advances in CO study.

Percutaneous Interventions for Congenital Heart Disease is written for pediatric cardiologists specializing in interventional cardiology and need a step-by-step guide to carrying out procedures, as well as adult cardiologists. Covering all kinds of interventions in congenital heart disease and the new field of structural heart disease, the book examines: Acquired valvular heart disease Post-myocardial infarction ventricular septal defects PFO closure Closure of the left atrial appendage Paravalvular leak closure Techniques for treating diseases of the aorta Hybrid procedures An essential text on how to perform interventional cardiology for congenital heart disease in both the pediatric and adult patient, this expertly written work will help to overcome barriers between pediatric and adult cardiologists, and pave the way for new cardiovascular interventionalists.

Written and edited by world-renowned leaders in the field! Presents new directions for the prevention and treatment of arterial and venous cardiovascular thrombotic and thromboembolic diseases. Updates contemporary thinking regarding low-molecular-weight-heparins (LMWH), platelet receptor antagonists, and direct thrombin inhibitors to manage acute coronary syndromes. Evaluates contemporary strategies for anticoagulation and antiplatelet therapy to improve early clinical outcomes following percutaneous coronary intervention. Offering diagnostic and management strategies to reduce morbidity and mortality from acute coronary syndromes and acute pulmonary embolism, Thrombosis and Thromboembolism is a superb reference for cardiologists, internists, primary care physicians, vascular medicine specialists, vascular surgeons, hematologists, pulmonologists and critical care physicians, cardiovascular surgeons, cardiac care nurses, and upper-level undergraduate, graduate, and medical school students in these disciplines.

Contents:
1. What do gap junctions do anyway? 2. Cardiovascular gap junctions: Functional Diversity, complementation and specialization of connexins 3. Endothelium and smooth muscle pathways for conduction along resistance microvessels 4. Membrane potential and calcium responses evoked by acetylcholine in submucosal arterioles of the guinea-pig small intestine 5. The effects of ouabain, 18a-glycyrrhetinic acid and connexin-mimetic peptides on intercellular communication in cells expressing a Cx43-GFP chimeric protein 6. Role of gap junctions in endothelium-dependent hyperpolarizations 7. Heterogeneity of EDHF-type relaxations of rabbit and rat arteries analysed with peptides homologous to the extracelluar loops of connexins 37, 40 and 43 8. Myoendothelial and circumferential spread of endothelium-dependent hyperpolarization in coronary arteries 9. Direct myoendothelial contact in human pulmonary microvessels 10. Role of gap junctional communication in EDHF-mediated responses and mechanisms of K-induced dilatations 11. Comparison of alpha and beta isoforms of glycyrrhetinic acid and carbenoxolone as inhibitors of EDHF-type relaxation 12. Inhibitory effect of 18-beta-glycyrrhetinic acid on the relaxation induced by acetylcholine in the rat aorta 13. A central role for endothelial cell potassium channels in EDHF-mediated responses 14. Could the EDHF be K in porcine coronary arteries? 15. Nitro-L-arginine/indomethacin-resistant relaxations to acetylcholine in small gastric arteries of the rat: Effect of ouabain plus Ba2+ and relation to potassium ions 16. Effects of barium, ouabain and K+ on the resting membrane potential and endothelium-dependent responses in rat arteries 17. EDHF and potassium: Blockade of chloride channels reveals relaxations of rat mesenteric artery to potassium 18. Cytochrome P450 2C is a source of EDHF and reactive oxygen species in the porcine coronary artery 19. Cortisol increases EDHF-mediated relaxations in porcine coronary artery 19. Cortisol increases EDHF-mediated relaxations in porcine coronary arteries and up-regulates the expression of cytochrome P450 2C9 20. An arachidonic acid metabolite(s) produced by the endothelial cytochrome P450 isoform, CYP3A4, relaxes the lingual artery of the monkey via K+ channel opening 21. EDHF-mediated responses induced by bradykinin in the porcine coronary artery 22. Epoxyeicosatrienoic acid release mediates nitric oxide-independent dilatation of rat mesenteric vessels 23. Epoxyeicosatrienoic acid and endothelium-dependent hyperpolarization in porcine coronary arteries 24. Lipoxygenase-derived metabolites of arachidonic acid are not involved in the endothelium-dependent hyperpolarization to acetylcholine in the carotid artery of the guinea-pig 25. Cytochrome P450 isoforms in the brain encode cell specific hyperpolarizing factors with a common mechanism of action 26. Expression of recombinant cytochrome P450 epoxygenase in rat brain 27. Identification of 11, 12, 15-trihydroxyeicosatrienoic acid as the mediator of acetylcholine- and arachidonic acid-induced relaxations in the rabbit aorta 28. Identification of hydrogen peroxide as an endothelium-derived hyperpolarizing factor in mice 29. Components of the potassium currents underlying the actions of endothelium- derived hyperpolarizing factor in arterioles 30. Evidence for relaxation to endothelium-derived hyperpolarizing factor (EDHF) in isolated small mesenteric arteries of the mouse 31. Pharmacological characterization of potassium channels in intact mesenteric arteries and single smooth muscle cells from eNOS-/- and +/+ mice 32. EDHF, which is not NO, is a major endothelium-dependent vasodilator in mice 33. Prostacyclin and iloprost in the isolated carotid artery of the guinea pig 34. Role of charybdotoxin/apamin sensitive K+ Ca channels in pulsatile perfusion- mediated coronary vasodilatation in vivo 35. Essential role of estrogen in the EDHF-mediated responses of mesenteric arteries from middle-aged female rats: Possible contribution of gap junctional protein connexin 43 36. Endothelium-derived hyperpolarizing factor (EDHF) and utero-feto-placental circulation in the rat 37. Endothelium-derived hyperpolarizing factor maintains a normal relaxation to bradykinin despite impairment of the nitric oxide pathway in porcine coronary arteries with regenerated endothelium 38. Mechanisms underlying the vasodilatation caused by bradykinin in essential hypertensive patients 39. Influence of diabetes on endothelium-dependent responses in mesenteric and femoral arteries of rats 40. Folate restores the NO synthase- and cyclooxygenase-resistant renal vasodilator response to acetylcholine in diabetes 41. Resistance of EDHF-mediated relaxations to oxidative stress in human radial arteries 42. Critical limb ischemia results in different types of endothelial dysfunction depending on the vascular bed studied 43. Potentiated EDHF-mediated dilatations in the rat middle cerebral artery following ischemia/reperfusion 44. The EDHF-dependent but not the NO-dependent component of the acetylcholine-induced relaxation of the rabbit aorta is resistant to ionized radiation 45. Inhibition of converting enzyme prevents the age-related decline in endothelium-dependent hyperpolarization 46. Effects of a converting enzyme inhibitor, an AT1-receptor antagonist and their combination on endothelial dysfunction in hypertension 47. EDHF: Gap junction or chemical? And many other questions

Contents:
1. Potassium Channels and Member Potential in Vascular Endothelial and Smooth Muscle Cells 2. Possible Contribution to CLCA1 to Calcium-Activated Chloride Channels in Murine Smooth Muscle Cells 3. Trafficking and Transduction Functions of the NA Pump in Vascular Smooth Muscle Cells 4. Isoforms of NA, K-Atpase 5. Calcium Sparks and Membrane Potential 6. Proteinase-Activated Receptor-2: Release of an Endothelium-Derived Hyperpolarizing Factor Distinct from that Released by Acetylcholine 7. Mechanical Stimulation Increases the Activity and Expression of Cytochrome P450 2C in Porcine Coronary Artery Endothelial Cells 8. Important Role of Hydrogen Peroxide as an Endothelium-Derived Hyperpolarizing Factor in Animals and Humans 9. Altered Calcium Dynamics do not Account for the Attenuation of EDHF-Mediated Dilatations in the Middle Cerebral Artery of Female Rats 10. Connexin-Mimetic Peptides: Influence of Nitric Oxide Synthase and Cyclooxygenase-Independent Renal Vasodilatation, Basal Renal Blood Flow and Blood Pressure in the Rat 11. Urocortin-Induced Relaxations of the Rat Coronary Artery 12. Nitric Oxide is the Only EDHF Released by the Endothelium in Lymphatic Vessels of the Guinea-Pig Mesentery 13. Role of EDHF in Vascular Tone in vivo 15. Improvement of Age-Related Impairment of Endothelium-Derived Hyperpolarization by Renin-Angiotensin System Blockade 16. Characterization of Endothelium-Derived Hyperpolarizing Factor-Mediated Relaxation of Small Mesenteric Arteries from Diabetic (DB/DB -/-) Mice 17. Endothelium-Dependant Responses in Small Arteries Isolated from Normal and Pre-Eclamptic Pregnant Women 18. Free Radical Species and Endothelium Dysfunction During Deoxycorticosterone-Salt Induced Hypertension 19. EDHF Involvement in Skin Pressure-Induced Vasodilation 20. N-Acetylcysteine and Immobilization Stress Attenuate the Dysregulation of Endthelium-Dependent Coronary Vascular Tone Induced by Acute Hemorrhage 21. Red Wine Polyphenolic Compounds Induce EDHF-Mediated Relaxation and Hyperpolarization in the Porcine Coronary Artery: Involvement of Redox-Sensitive Mechanisms 22. Estrogen Substitution Restores the Basal Influence of Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor on Vascular Tone in Isolated Mesenteric Arteries from Ovariectomized Rats 23. Ascorbate Inhibits EDHF in the Bovine Eye but not in the Porcine Coronary artery 24. Gabexate Mesilate Inhibits Endothelium-Dependent Relaxation, But Causes Endothelium-Independent Relaxation of Rat Blood Vessels 25. Mechanisms Underlying Basal Vascular Tone in the Guinea-Pig Mesenteric Aterioles 26. Endothelium-Dependent Depolarization and its Implications for Endothelium-Derived Hyperpolarizing Factor 27. Role of Gap Junctions in EDHF-Mediated Relaxation Response in Human Subcutaneous Resistance Arteries 28. Permissive Role of Camp in the Mediation of Relaxations Initiated by Endothelial Hyperpolarization 29. Myoendethelial Gap Junctions

The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data. FEATURES Reflects emerging concepts impacting diagnostic and therapeutic approaches Explores background, history, epidemiology, and risk factors Describes pharmacological, nonpharmacological, and medical treatments Examines hypertension in special populations and treatment

Key features: The most comprehensive resource available on the biodiversity of algal species, their industrial production processes and their use for human consumption in food, health and varied applications. Emphasis on basic and applied research, addressing aspects of scale-up for commercial exploitation for the development of novel phytochemicals (phytochemicals from algae). Addresses the underexplored and underutilized potential of chemicals from marine sources for health benefits. Each chapter, written by expert contributors from around the world, includes Summary Points, Figures and Tables, as well as up-to-date references. The first book in this two-volume set explores the diversity of algal constituents for health and disease applications. The commercial value of chemicals of value to food and health is about $6 billion annually, of which 30 percent relates to micro and macro algal metabolites and products for health food applications. This comprenhensive volume looks in detail at algal genomics and metabolomics as well as mass production of microalgae. As a whole, the two-volume set covers all micro and macro algal forms and their traditional uses; their constituents which are of value for food, feed, specialty chemicals, bioactive compounds for novel applications, and bioenergy molecules. Bio-business and the market share of algae-based products are also dealt with, providing global perspectives.

With the gradual transition from the technology-driven, intervention-oriented perspective of the last decade to a new, preventive, molecular-based perspective, Joanne Foody, MD, has amassed new preventive measures for use in everyday practices in this new edition of Preventive Cardiology. This new edition provides practical information for the management of patients at risk for cardiovascular disease and also offers an overview of the new paradigms in the pathophysiology of coronary artery disease (CAD).
Divided into three parts, Part I focuses on the atherosclerotic process, the important central role of the endothelium in the maintenance of cardiovascular health, and the role of inflammation in CAD. Part II provides insights into gender-specific aspects of CAD risk and concentrates on traditional cardiovascular risk factors. Part III provides an overview of approaches for the identification of patients at risk for CAD events and reviews of stress testing in patients with CAD and the important role of antiplatelets in coronary disease.
Preventive Cardiology: Insights Into the Prevention and Treatment of Cardiovascular Disease, Second Edition provides an overview of the exciting opportunities to prevent the progression, and in some instances to regress the process, of coronary atherosclerosis and incorporate these strategies into the daily practice of clinical medicine. This valuable new edition provides clinical cardiologists, internists, primary care providers, and allied health care professionals with the tools and understanding necessary for their practice in preventive cardiology.

Nitric oxide is involved in the regulation of the circulation in physiologic and pathophysiological conditions. Evidence indicates that alterations in endothelial production of nitric oxide may be involved in the pathogenesis of central hypertension, pulmonary hypertension, renal disease and coronary vasopastic disorders. In addition to being involved in regulation of the circulation in physiologic and pathophysiologic conditions, the inducible form of the enzyme may play a role in the refractory hypertension.

Answering the demand for acomprehensive, all-purpose volume focusing on the challenging needs of pediatric patients, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients summarizes a wealth of knowledge on the mechanical devices, clinical management, alternative applications, and future directions in the specialized field of pediatric critical care. Condensed advice from experts on the shelf offers guidance in critical intensive care settings! Combining clinical aspects with the latest experimental results, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients -examines current modalities and the best uses of mechanical support, including step-by-step techniques for extracorporeal membrane oxygenation (ECMO), ventricular assist devices (VAD), and intra-aortic balloon pumps -highlights the use of mechanical support in nonsurgical diseases such as myocarditis and cardiomyopathy, with implanted ventricular devices and in long-term follow-up care -discusses the optimal management for perioperative support in cardiac and pulmonary transplantations in children -reviews successful cases of mechanical support, including resuscitation after cardiac arrest, pediatric patients with myocarditis, and circulatory support of patients without cardiac disease -explores anticipated improvements and uses of the Berlin Heart, the Nimbus Rotary Pump, and applications of the Medos-HIA VAD in young patients -and much more! Authored by nearly 40 internationally recognized experts and containing over 500 literature references, drawings, photographs, and tables, Mechanical Support for Cardiac and Respiratory Failure in Pediatric Patients is an invaluable referencefor cardiologists and pediatric cardiologists, intensivists, cardiac surgeons, pulmonologists, anesthesiologists, general pediatricians, nursing personnel, perfusionists, and medical school students in these disciplines.

All junior doctors and in particular trainee cardiologists will at some point in their training be involved in managing acute coronary syndromes and other cardiac emergencies. This handbook sets out the recognized clinical steps to take and backs them up with an analysis of the evidence supporting these decisions. Evidence-Based Coronary Care willprovide junior doctors with the answers they seek when dealing with difficult clinical situations. Evidence-Based medicine is still very topical, and this book will adopt a similar style to James: Evidence-Based Obstetrics in setting out the clinical management plan on the verso page and the evidence supporting that plan on the recto page.Two page spread design showing management plan on verso page and supporting evidence on the recto page All forms of cardiac emergencies are coveredIncludes inpatient and outpatient scenarios Complete coverage of different drugs in use for MI and unstable anginaIncludes cost/benefits analyses Didactic approachBased on up-to-date literature survey

Summarizing state-of-the-art developments in long-term mechanical ventilation use, this comprehensive treatise reviews the applications, complications, and care of breathing disorders affecting the growing population of ventilation-assisted individuals-including neuromuscular and chronic obstructive pulmonary diseases (COPD) and chest wall deformities.
Qualitatively considers reimbursement options for management outside of acute care settings
Covering both noninvasive ventilation (NIV) and invasive ventilation techniques and procedures, Long-Term Mechanical Ventilation
provides an epidemiology of long-term mechanical ventilation with a review of recent trends
examines the pathophysiological mechanisms contributing to chronic respiratory failure, including the pathogenesis and treatment of restrictive thoracic and central hypoventilatory disorders
investigates the controversy over conflicting results for NIV management of patients with chronic respiratory failure due to severe stable COPD
details critical care for children with severe ventilatory defects such as congenital neuromuscular diseases, cystic fibrosis, and bronchopulmonary dysplasia
chronicles new insights into the role of the upper airway and glottis in determining the effectiveness of NIV
considers weaning dependent patients off ventilation and methods of care for different sites using the least complicated and most economical means
explores tools for measuring the impact and outcomes of long-term mechanical ventilation and determining patients' quality of life
and more
Containing over 1400 literature references, tables, drawings, and photographs, Long-Term Mechanical Ventilation is a necessary reference for pulmonary and thoracic specialists, chest physicians, anesthesiologists, physiologists, physiatrists and rehabilitation physicians, respiratory therapists, intensive care specialists, and medical school and graduate school students in these disciplines.

Venous disorders, while generally not life-threatening, affect millions worldwide, causing pain, disability and negatively impacting the lives of sufferers. Enormous advances have been made recently in treatments, providing minimally invasive solutions, increasing rates of success, low rates of morbidity and better care for a greater number of patients. With contributions from experts in a number of specialties, this highly practical guide provides an understanding of the pathophysiology of venous disease and authoritative information on management, and details of all the current treatment options available to physicians. The new techniques and skills described in this book afford patients with venous disease healthier and more productive lives. The Fundamentals of Phlebology is a valuable resource for all those involved in the field, including physicians from a variety of specialties, including dermatology, vascular surgery, and interventional radiology, also also for nursing staff, ultrasonographers, allied health professionals, and scientists. The Editor, Helane Fronek MD, is a Fellow of the American College of Phlebology and the American College of Physicians, and has specialized since 1986 in the field of Phlebology, recently recognised by both the American Medical Association and American Ossteopathic Association as a distinct medical specialty field.

This collection of articles on oxidative stress in clinical practice surveys essential current research in what is a rapidly evolving field. As well as giving the reader a mechanistic overview of how oxidative stress affects cardiovascular disease, it analyzes the potential of a number of therapeutic options that target these pathways. Understanding the complexity of the cellular redox system could lead to the development of better targeted interventions that facilitate patient recovery. Even as large-scale clinical trials of so-called simple' antioxidant approaches such as vitamins C and E show that significant benefits for cardiovascular patients remain elusive, Studies on Cardiovascular Disorders demonstrates that such approaches are too simplistic. Beginning with a summary of redox signalling models that could induce the progression of redox-associated cardiovascular disorders, the volume moves on to examine redox-mediated protein modification under physiological and pathophysiological conditions. It provides an outline of the signalling pathways in cardiovascular development during embryogenesis and what impact these might have in the differentiation process of resident cardiac and blastocyst-derived stem cells. Further chapters detail our current knowledge of the influence the sensory nervous system exerts on the cardiovascular system, and the paradoxical role of mitochondria-derived ROS in cardiac protection. In all, almost 30 contributions cover issues as diverse as the antioxidant properties of statins in the heart and the oxidative risk factors for cardiovascular disease in women. A range of medical practitioners will find the contents of Studies on Cardiovascular Disorders provides illuminating insight into the Janus-faced role of ROS in the cardiovascular system.

Vortex Formation in the Cardiovascular System will recapitulate the current knowledge about the vortex formation in the cardiovascular system, from mechanics to cardiology. This can facilitate the interaction between basic scientists and clinicians on the topic of the circulatory system. The book begins with a synopsis of the fundamentals aspects of fluid mechanics to give the reader the essential background to address the proceeding chapters. Then the fundamental elements of vortex dynamics will be discussed, explaining the conditions for their formation and the rules governing their dynamics. The main equations are accompanied by mathematical models. Cardiovascular vortex formation is first analyzed in physiological, healthy conditions in the heart chambers and in the large arterial vessels. The analysis is initially presented with an intuitive appeal grounded on the physical phenomena and a focus on its clinical significance.In the proceeding chapters, the knowledge gained from either clinical or basic science literature will be discussed. The corresponding mathematical elements will finally be presented to ensure the adequate diligence. The proceeding chapters ensue to the analysis of pathological conditions, when the reader may have developed the ability to recognize normal from abnormal vortex formation phenomenon. Pathological vortex formation represents vortices that develop at sites where normally laminar flow should exist, e.g. stenosis and aneurisms. This analysis naturally leads to the interaction of vortices due to the surgical procedures with respect to prediction of changes in vortex formation. The existing techniques, from medical imaging to numerical simulations, to explore vortex flows in the cardiovascular systems will also be described. The presentations are accompanied by the mathematical definitions can that be understandable for reader without the advanced mathematical background, while an interested reader with more advanced knowledge in mathematics can be referred to references for further quantitative analyses. The book pursues the objective to transfer the fundamental vortex formation phenomena with application to the cardiovascular system to the reader. This book will be a valuable support for physicians in the evaluation of vortex influence on diagnosis and therapeutic choices. At the same time, the book will provide the rigorous information for research scientists, either from medicine and mechanics, working on the cardiovascular circulation incurring with the physics of vortex dynamics.

Public interest in the health impacts of carbon monoxide (CO) has been increasing rapidly during the past decade. And rightly so: it is the most ubiquitous environmental poison. Car exhaust fumes, furnaces, gas-powered engines, home water heaters, smoke from all types of fire, and tobacco smoke all contribute to carbon monoxide intoxication - the leading cause of poisoning death in the United States. Even when it doesn't cause death, it often produces lasting, deleterious effects on the central nervous system.

From one of the world's top CO experts, Carbon Monoxide Toxicity examines the latest basic science and clinical research from around the world. It addresses the gamut of health-related CO issues, from the history of CO studies to the hidden threat of chronic low-level exposure. The broad themes center on clinical management of various forms of CO poisoning and education of the public on the constant dangers of CO.

Thanks to the success of CO environmental health regulations in the U.S., society is much more aware of the threat of CO poisoning. Increasing numbers of people use CO detectors in public buildings, homes, pleasure boats, and aircraft. Carbon Monoxide Toxicity meets the need for current research on the clinical management of CO poisoning.


Visit the author's Web site at www.coheadquarters.com

A growing number of people suffer from so-called resistant hypertension, that is to say, high blood pressure that does not respond to treatment. This disorder is of great current interest and importance for public health, being a common clinical problem faced by both primary care clinicians and specialists. Furthermore, as older age and obesity are among the strongest risk factors for uncontrolled hypertension, the incidence of resistant hypertension will likely increase as the population becomes more elderly and heavier. While the prognosis of resistant hypertension is unknown, cardiovascular risk is undoubtedly increased since patients often have a history of long-standing, severe hypertension complicated by multiple other cardiovascular risk factors. This volume, compiled by a panel of world-renowned experts, offers a comprehensive exploration of resistant hypertension, covering epidemiology, complex diagnostic aspects, and the therapeutic options currently available, with due attention to overall treatment strategies. New therapeutic agents and procedures, such as renal denervation and baroreceptor stimulation, are also described. In addition, the book addresses the economic aspects of resistant hypertension and the role of the different professional figures, from GPs to hypertension specialists, in dealing with it.

The latest volume in the series based on the Annual Stress and Coping Symposia held at the University of Miami, Drs. McCabe, Schneiderman, Field, and Wellens bring together an outstanding group of researchers to examine the relationship between bio-behavioral and social factors and heart disease.
Highlights of the book include an in-depth look at the latest research on:
* basic physiological processes in cardiovascular reactivity to stress;
* pathophysiological mechanisms in cardiovascular disease;
* ethnic differences in cardiovascular regulation;
* psychosocial influences on cardiovascular function/disease; and
* Behavioral interventions designed to treat cardiovascular disorders.
The goal of "Stress, Coping, and Cardiovascular Disease" is to provide a solid empirical foundation on the relationship between stress and cardiovascular disease so as to stimulate further research into the pathophysiology and treatment of the leading cause of death in industrialized countries.

Since the publication of the 3rd Edition 17 years ago, progress has been truly remarkable in all areas of electrocardiography. Five of the seven chapters in this 4th Edition have been extensively revised. Out of the total of 125 ECGs, 65 are new. Each ECG is crisp and clear and all the abnormalities are highlighted by arrows for easy recognition and understanding. This book is the culmination of the author's 45 years of experience in the teaching of electrocardiography to coronary care unit nurses, medical undergraduates, postgraduates, interns, residents, senior residents and above. As the title of the book implies, the approach to the subject has been entirely from the viewpoint of a clinician. Hence, clinical-electrocardiographic correlations have been emphasized simply and succinctly throughout the text.

Authoritative, portable, and up to date, Opie's Cardiovascular Drugs, 9th Edition, is the definitive reference for quick access to frequently used drugs in all phases of care for cardiac patients. Now a part of the Braunwald family of renowned cardiology references, this compact title provides crucial information in an easily accessible format-ideal for cardiologists, residents, cardiology fellows, medical students, nurses, and other cardiac care providers. Updated to include the latest guidelines and evidence-based implications, it offers clear and concise explanations and pertinent clinical facts for all classes of cardiac drugs, as well as all the latest clinical trial results and evidence for the pharmacologic treatment of heart disease. Uses a new, consistent format for each drug class: overview and guidelines for use, mechanisms of action, differences among drugs in class, data for use, side effects, and drug interactions. Covers key topics such as new ESC and NLA guidelines, advances in lipid-lowering therapy, new diabetes drugs that improve cardiovascular outcomes, obesity drugs and cardiovascular and metabolic effects, drugs targeting inflammation, and combinations of antithrombotic therapies with analysis of risk-benefit. Provides guidance on how to effectively manage comorbid diseases. Contains dozens of unique "Opiegram" diagrams that demystify complex mechanisms of action and other drug processes-many updated to reflect current pathologic understanding of mechanisms. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Mechanical Circulatory Support: Principles and Applications offers innovative approaches to complex clinical scenarios and represents the current state-of-the-art for managing patients on mechanical circulatory support devices. Topics are presented in a concise fashion, making it a practical resource for care givers who need a user's manual in the heat of the moment during patient care as well as a reference for a better understanding of the unique components of every device available for human use. This book provides a comprehensive, up-to-date analysis of the most relevant issues facing health care providers in the management of advanced heart failure. With content that features patient selection strategies, implantation techniques, device specific considerations, and management of clinical challenges in the post-operative setting, this textbook offers evidence-based answers to the complex questions facing nurses, perfusionists, advanced practice providers, and physicians.

Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility provides cutting-edge information and solutions to help support the worldwide rise of fertility challenges. It addresses common, yet not commonly known, root-causes of oxidative stress that are at the heart of reproductive issues (and all chronic health issues). These solutions can help enhance the outcomes of Assisted Reproductive Technologies (ART) or support women to avoid them altogether. Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility will show you how to improve cell health (including egg and sperm), lower inflammation, balance nervous system functioning, and optimize genetic expression, allowing the body to return to its naturally fertile state. It details information on numerous root causes of health-derailing inflammation and oxidative stress, while the appendices discuss the genetic and biochemical pathways related to these topics. Each chapter also provides easy "Action Steps" that can be implemented immediately. Chapter topics include iron dysregulation; oxalates; mold/mycotoxins; phase 2 liver detoxification pathways; fat utilization; introductory information on genetics, epigenetics, and nutrigenomics; everything one needs to know about histamine intolerance; and how these factors adversely affect metabolic and reproductive functions. Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility is the handbook for people wanting to achieve and sustain a healthy pregnancy. It highlights lesser-known causes of fertility challenges the reader can learn how to investigate. This book also serves as a reference guide for practitioners, providing them with additional tools to add to their repertoires when other protocols have not been effective. It may also provide clarity as to why other protocols did not work, and will enable the practitioner to custom-tailor protocols for each patient.