Written and edited by world-renowned leaders in the field! Presents new directions for the prevention and treatment of arterial and venous cardiovascular thrombotic and thromboembolic diseases. Updates contemporary thinking regarding low-molecular-weight-heparins (LMWH), platelet receptor antagonists, and direct thrombin inhibitors to manage acute coronary syndromes. Evaluates contemporary strategies for anticoagulation and antiplatelet therapy to improve early clinical outcomes following percutaneous coronary intervention. Offering diagnostic and management strategies to reduce morbidity and mortality from acute coronary syndromes and acute pulmonary embolism, Thrombosis and Thromboembolism is a superb reference for cardiologists, internists, primary care physicians, vascular medicine specialists, vascular surgeons, hematologists, pulmonologists and critical care physicians, cardiovascular surgeons, cardiac care nurses, and upper-level undergraduate, graduate, and medical school students in these disciplines.

The first book of its kind, Pediatric Heart Failure describes current diagnostic and treatment strategies for acute and chronic heart failure in the fetus, neonate, child, and young adult. It encompasses every aspect of pediatric heart failure, including historical perspectives, the latest technologies in mechanical circulatory support, and the psychosocial aspects of heart failure in children. Coverage includes the causes and treatment of heart failure in the fetus, the developmental, cellular, neurohormonal, and immunologic mechanisms of pediatric heart failure, the genetic aspects of heart failure, and the alterations in cardiac function that occur after heart transplantation in children.

Patent Foramen Ovale (PFO) Closure for Stroke, Myocardial Infarction, Peripheral Embolism, Migraine, and Hypoxemia is a complete reference covering the association between PFO and numerous medical conditions. It provides a background on the topic including embryology, anatomy, and physiology. This book fully examines the diagnosis and imaging assessment of PFO and discusses the data linking PFO to various clinical pathologies. It details technical aspects of PFO closure and includes perspectives on future outlooks and where the field is headed in terms of device closure indications. This is a complete reference book for cardiologists, interventional cardiologists, neurologists, pulmonologists, general practitioners, medical professionals, and researchers who are interested in PFO-associated pathologies, technical aspects, safety, and future outlooks of PFO device closure.

This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.

Various foods, herbs and spices are used to treat or prevent disease and there have been considerable advances in scientific techniques over the last few decades. These have been used to examine the composition and applications of traditional cures. Modern science has also seen the investigation of herbs, spices and botanicals beyond their traditional usage. Contributions are from leading national and international experts including those from world renowned institutions. Please target oncologists, cancer specialists, physicians, health scientists, healthcare workers, pharmacologists, and research scientists. The audience also includes federal and state program directors. It is valuable to academic libraries that cover the domains of health and medical sciences. It is also suitable for undergraduates, postgraduates, lecturers, and academic professors.

Key features: • Expanded first chapter on levels of echocardiography. • New sections on COVID-19, cardio-oncology, multivalve disease, and specialist valve clinics. • Incorporation of new international guidelines, grading criteria and normal data. • Guide to how cardiac CT and magnetic resonance can compliment echocardiography. • Reformatted text and extra diagrams and tables to improve understanding.

The field of stroke and cerebrovascular disease in children is one in which there has been much recent research activity leading to new clinical perspectives. This book, for the first time, summarises the 'state of the art' in this field. A team of eminent clinicians, neurologists and researchers from Britain, Europe and Canada provide an up-to-the-minute account of all aspects of stroke and cerebrovascular disease in children, ranging from a historical perspective to future directions, through epidemiology, the latest neuroimaging techniques, neurodevelopment, co-morbidities, diagnosis and treatment. The authors' practical approach to the clinical problems makes this essential reading for practising clinicians. It will also be of interest to researchers in the field.

This issue of Cardiac Electrophysiology Clinics, Guest Edited by Dr. Jagmeet P. Singh and Dr. Gopi Dandamudi, focuses on Cardiac Resynchronization. Topics include--but are not limited to--The many faces of heart failure, Economic impact of chronic HF management in today's cost-conscious environment, Contemporary treatment of HF, Why dyssynchrony matters in HF, Utility of echocardiography in assessing dyssynchrony, Cardiac Magnetic Resonance Imaging as a tool to assess dyssynchrony, Current clinical evidence favoring CRT & When to implant CRT in HF patients, How to implant CRT devices in a busy clinical practice, Tips and tricks for challenging implants, Explanting chronic CS leads, Optimizing CRT devices in follow-up to improve response rates and outcomes, Increasing role of remote monitoring of CRT devices in improving outcomes, CRT in preserved to mildly reduced systolic function, Role of AVJ ablation and CRT in patients with chronic AF, Gender based differences in CRT response, Benefits of multisite/multipoint pacing to improve CRT response, LV endocardial pacing/leadless pacing, and Evolving role of permanent His bundle pacing in conquering dyssynchrony.

Since the publication of the first edition of Cardiac Pacing for the Clinician, the use of implantable cardiac devices has expanded rapidly. Certain classes of devices such as implantable loop recorders and cardiac resynchronization pacing systems were not commonly used when the first edition was published, and recent studies have shown that implantable cardioverter defibrillators are beneficial in large, previously unrecognized patient populations at risk for sudden death. In order to meet this demand, cardiologists without special training in electrophysiology or pacing are implanting an increasing number of cardiac devices. It is in this rapidly evolving setting that Cardiac Pacing for the Clinician, Second Edition is being undertaken.

The main focus of this volume will be to provide a practical discussion of the a oenuts and boltsa of implantable cardiac devices. The target audience will be cardiologists in practice and in training as well as nurses, technologists and industry. In addition, it will benefit physicians preparing for certification.

Additions to the new edition will include: Chapters discussing new cardiac devices; Implantation of Left Ventricular Leads for Cardiac Resynchronization Pacing Systems; Identification of Candidates for Cardiac Resynchronization Therapy; Follow-Up Issues in Cardiac Resynchronization Therapy; Implantable Loop Recorders.

Updates to the existing chapters will include: New Trial Information & Follow-Up of the Newest Generation of Defibrillators; Use of Defibrillators in Patients at Increased Risk for Sudden Cardiac Death due to Long QT Syndrome, Brugada Syndrome and Congenital Heart Disease; Updates to Lead Extraction a" NewTechniques and Tools; Cardiac Pacing chapter will shift focus to Cardiac Devices.

This new edition of Cardiac Pacing for the Clinician, Second Edition will become a valuable resource to the general cardiologist and cardiology fellow by providing practical information for managing patients with complex cardiac devices.

Interventional cardiology has transitioned from angiographic subjective analysis of stenosis severity into assessment of plaque characteristics and objective assessment of stenosis severity. The evolution of novel interventional imaging modalities is progressively altering our understanding of coronary artery disease diagnosis and prognosis. This book will be an essential companion to assist interventional cardiologists in better assessing patients with Coronary Artery Disease. It will encompass and review all interventional imaging modalities and provide guidance for interventional cardiologists to use these modalities.

An illuminating and timely synthesis of methodological and clinical studies showing how medical costs can be established, how the value of clinical outcomes can be assessed, and how difficult choices can be rationally made. The methodological chapters review the conceptual and practical issues involved in estimating and interpreting health care costs, making health status and utility assessments, and statistically analyzing cost-effectiveness and clinical trials. The clinical chapters apply these methods to the major clinical areas of cardiology-primary prevention of coronary artery disease, acute coronary syndromes, angioplasty vs coronary bypass surgery, CABG vs medicine, congestive heart failure, arrhythmias, and cardiac surgery. Additional chapters consider the use of economic studies for policy purposes and the future of Medicare under a balanced budget in an aging America.

Sex Differences in Cardiovascular Physiology and Pathophysiology is a comprehensive look into the often overlooked and underappreciated fundamental sex differences between men and women and how those differences affect the cardiovascular system. It covers cardiovascular function, anatomy, cell signaling and the development of pathology. With contributions from world-renowned research investigators, this up-to-date reference compiles critical knowledge on cardiovascular sex differences, providing researchers and clinicians with a better understanding of the diagnosis, prevention and treatment of cardiovascular diseases in both men and women.

This guide provides a comprehensive review of the full spectrum of hypertension in chronic kidney disease (CKD). Targeted towards the busy practitioner, the focus of this volume is on various therapies and how to lower blood pressure through lifestyle changes. Specialist patient populations and hypertension and causes of hypertension are also covered in detail. Clinically-focused and authoritative, this resource offers a rationalized approach to diagnosing and treating hypertension in CKD.

This issue of Cardiology Clinics, guest edited by Drs. Srihari S. Naidu and Julio A. Panza, will focus on Hypertrophic Cardiomyopathy. Articles in this issue include: Historical Perspective and the Diagnostic Dilemma, Echocardiography for Diagnosis and Management, Cardiac Magnetic Resonance for Diagnosis and Risk Stratification, Genetic Testing and Counseling, Role of Advanced Testing: Invasive Hemodynamics, Biopsies and CPET, Lifestyle Modification and Medical Management, Arrhythmia Evaluation and Management, Sudden Cardiac Death Risk Stratification and the Role of the ICD, Choice of Septal Reduction Therapies and Alcohol Septal Ablation, Surgical Myectomy: Sub-aortic, Mid-ventricular and Apical, Advanced Heart Failure Management and Transplantation, Novel Pharmacotherapy, and Unresolved Issues and Future Directions.

Recognized scientists and clinicians from around the world discuss the most recent molecular approaches to understanding the cardiovascular system in both health and disease. The authors focus on all components of the system, including blood vessels, heart, kidneys, and the brain, and cover disease states ranging from vascular and cardiac dysfunction to stroke and hypertension. The methods described for identifying the genes that cause susceptibility to cardiovascular diseases emphasize the possibility of discovering new drug targets. Authoritative and ground-breaking, Cardiovascular Genomics offers an unprecedented examination of both the cutting-edge scientific approaches now possible and the results obtained from them in the new science of cardiovascular genomics.

Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today's available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. Covers lab standards and statistical interpretation of biomarkers with a clinical focus. Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future.

This new account of the pathogenesis of essential hypertension (EH) represents a detailed analysis of the main components of the circulatory control system. The latter's properties resemble those of man-made adaptive control systems in which regulatory parameters are altered when operating conditions exceed certain limits, often through neural mechanisms.
Inheritance of EH depends on both genes and environment. The high blood pressure (BP) genes have not yet been definitively identified, whilst the main environmental causes are mental stress, high dietary salt intake and obesity. EH occurs as two major syndromes, each initiated by chronic stress: 1) Stress-and-salt related EH, and 2) Hypertensive obesity. Stress is perceived by the cortex, from which increased dopaminergic (DA) neuron activity stimulates the hypothalamic defense area, raising sympathetic neural activity (SNA) and BP. Normally these subside quickly when the stress is over, but in those susceptible to EH the DA synapses become sensitized so that the defense response is evoked by ever lower levels of stress. Sensitization is common in memory circuits, but not in autonomic neurons, so that this property in EH may be genetically determined.
Stress-related hypertension increases hypothalamic responsiveness to high salt, resulting in further rises in SNA and BP. Later, non-neural functional changes (e.g. reduction in nitric oxide) and the structural remodeling of resistance vessels further enhance the vasoconstriction. In contrast, in those developing hypertensive obesity food consumption is excessive, which transiently alleviates stress-related anxiety. The brain ignores the leptin-mediated signals that normally curbappetite, contrasting with normal energy regulation in SSR-EH. In hypertensive obesity, the SNA pattern is similar to that in SSR-EH, but vasoconstriction is masked by vasodilatation and fluid retention due to hyperinsulinemia. This syndrome is a volume overload hypertension, where high cardiac output, renal impairment and other non-neural factors contribute to the elevation of BP.
Other topics include the role of various transmitters in autonomic regulation; the place of baroreflexes in the intact organism; why exercise training lowers resting BP; obstructive sleep apnea; non-pharmacological and drug treatment of EH; the role of the kidney in EH and in different types of renal hypertension and the pathogenesis of the Japanese spontaneously hypertensive rat, which provides a valuable animal model for EH.
The work suggests that physiological systems analysis in a complex disorder like EH is a valuable tool for using the great advances in molecular biology to best advantage.

This issue of Cardiology Clinics, edited by Drs. Palak Shah and Jennifer Cowger, will focus on Mechanical Circulatory Support. Topics include, but are not limited to, The Evolution of Mechanical Circulatory Support, Continuous-flow Device Engineering and Pump Technology, Surgical Implantation: Perspective and Techniques, Temporary Circulatory Support and ECMO, Durable MCS Candidate Selection, Perioperative Management of the Right and Left Ventricle, Quality of Life, Frailty and Cognitive Impairment in the MCS Candidate, Microbiology and Infections in VAD recipients, Gastrointestinal Bleeding, Cerebrovascular Accident, Antithrombotic Strategies and Device Thrombosis, Impact of MCS on Post-Transplant Outcomes, Hemodynamic Pump-Patient Interactions & VAD Imaging, Ambulatory Patient Management, and Imaging in VAD recipients.

Covering the full spectrum of CHD from infants through adults, Perloff's Clinical Recognition of Congenital Heart Disease, 7th Edition, provides unparalleled guidance on the diagnosis and treatment of common and uncommon CHD in one definitive resource. The editors of this new edition, Drs. Ariane J. Marelli and Jamil A. Aboulhosn, have maintained Dr. Joseph Perloff's richly nuanced approach while bringing this classic text completely up to date with all the latest evidence and technologic advances in the field. With its comprehensive, step-by-step approach, you'll acquire a structured understanding of CHD across age ranges, allowing you to effectively detect these conditions as early as possible.NEW in the 7th Edition: Updated images throughout, as well as phonocardiograms, electrocardiograms, flow charts, and anatomic drawings Specific, integrated findings for individual patients with Dr Perloff's classic approach to diagnosis and treatment Streamlined review of sequelae and complications Historical Notes at the beginning of each chapter Tips on selecting among the increasing array of currently available procedures, helping foster and develop clinical judgment skills Update on genetic contributions to clinical recognition for a more complete presentation of patient diagnosis. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Get a quick, expert overview of the many key facets of adult congenital heart disease (ACHD) with this concise, practical resource by Drs. Seshadri Balaji, Ravi Mandapati, and Gary Webb. This easy-to-read reference presents a case-based approach to this fascinating and complex field. Presents cases provided by ACHD specialists of patients with arrhythmia issues, which are evaluated by an international panel of arrhythmia experts. Provides commentary and practical guidance on management of complex cases by today's leaders in the field. Consolidates today's available information and experience in this emerging area into one convenient resource.

A comprehensive survey of nonsurgical treatment for a variety of heart diseases that affect the cardiac valves, the heart muscle, and the structure of the heart. The authors describe who these procedures are useful for, how to do them, and how well they work. Major topics of discussion include percutaneous techniques for valvular heart disease, septal defects at both the atrial and ventricular levels, adjunctive therapies during coronary interventions, and angioplasty to treat extracardiac vascular disease, as well as reviews of the cutting-edge imaging modalities now being used in interventional procedures. An accompanying CD-ROM contains video demonstrations of catheterization and and the imaging portions of these procedures.

This issue of Cardiology Clinics, edited by Dr. Andrew M. McCoy, will focus on Resuscitation. Topics include, but are not limited to Improving survival in your community, Compression only CPR, Dispatch, CRP quality issues, Drugs in OHCA, Mechanical CPR, DSeD, Nuances of Airway Management in OHCA, refractory/recurrent VF, future of OHCA care, and more.

In The Practice of Electrocardiography, a master practitioner offers an organized approach to the art of EKG interpretation. Moving beyond the traditional approaches of many books that stress technical skill and pattern recognition, Dr. Blake shows how the four measurements needed to examine a tracing (orientation, duration, amplitude, and contour of each component) may be used with consistency and medical rigor for distinguishing normal and abnormal EKG patterns.
A unique worksheet guides the analytic process item by item and clarifies the logic of each stage of interpretation, in the same way that a dissection manual leads the student in an anatomy course. The result is a method for interpreting the electrocardiogram that reveals the anatomy and physiology behind each waveform and illuminates the gray areas between normal and abnormal.
The Practice of Electrocardiography provides a firm foundation in the diagnostic methods and clinical application of electrocardiography, as well as an entry into the literature through an outstanding bibliography. It will enable medical and nursing students to analyze the tracings they encounter in day-to-day practice with confidence and real understanding. Practicing clinicians will also find fresh insights here, and there are sections for technicians and their supervisors, as well as for administrators and others charged with assessing competence in the field.
After a lifetime of teaching and practicing EKG production and interpretation, after seeing more than a million EKG tracings over the years, Dr. Blake has distilled in The Practice of Electrocardiography the essence of his art and understanding for all those who must recordtracings, interpret them, or judge an interpretation written by someone else.

Aortic dissection affects approximately two in ten thousand individuals and can be fatal. This state-of the-art publication is a result of the combined efforts of participants from the International Registry of Aortic Dissection (IRAD). The book has been divided into sections. Each chapter provides a succinct overview of the current clinical literature and incorporates illustrations for further explanation.

Cardiovascular disease affects 20% of all Americans and is the leading cause of death in the USA. Every year approximately 1,500.000 Americans suffer from an acute myocardial infarction, and over 25% of the total number of deaths in this country are attributable to coronary artery disease. Unstable angina causes over 650,000 hospital admissions, and in the absence of medical therapy, the rate of progression from unstable angina to infarction is 12-20%. Since plaque disruption, plaque erosion, and acute intracoronary thrombus formation play major roles in the pathophysiology of both unstable angina and acute myocardial infarction, and since the two disease entities represent a continuum of coronary ischemic syndromes, it is appropriate to discuss the two disease states in a single monograph. Unstable Coronary Artery Syndromes, Pathophysiology, Diagnosis and Treatment will offer the clinician a reference book which coherently discusses the pathophysiology of acute ischemic syndromes as well as remarks diagnosis and treatment strategies. Geared toward internists and cardiologists, the book should allow the reader to understand the pathophysiology of unstable coronary artery syndromes and subsequently apply this knowledge to patient care.