Nutrition plays a key role in prevention of cardiovascular disease, the leading cause of death worldwide. Diet influences a broad spectrum of cardiometabolic risk factors, notably a cluster including excess adiposity, dyslipidemia, impaired glucose metabolism and high blood pressure. In the face of the rapidly increasing incidence of obesity and diabetes, maintaining cardiometabolic health through adoption of a healthy lifestyle is a top public health priority. In this book, Nutrition and Cardiometabolic Health, international experts present state-of-the-art scholarly reviews of dietary and lifestyle effects on metabolic systems associated with cardiovascular health and disease. It covers a broad range of topics including biological and behavioral processes regulating food intake; lifestyle and surgical approaches to weight loss; nutritional considerations for optimal cardiometabolic health across the lifespan; the relationship of macronutrients, whole foods and dietary patterns to diabetes and cardiovascular disease; and diet as a modulator of gene expression, epigenetics and the gut microbiome and the relationship of these traits to disorders of metabolism. This book provides its readers with an authoritative view of the present state of knowledge of dietary effects on cardiometabolic health and will be of interest to nutrition and healthcare professionals alike.

Pericardial disease is a broad term that describes a wide range of pathologies. The clinical aspects of pericardial disease encompass acute pericarditis, pericardial tamponade, pericardial effusion, constrictive pericarditis, and effusive-constrictive pericarditis. Those disorders differ not only in clinical presentation but also in the timeline of disease development; for example, pericardial tamponade is commonly an acute, life-threatening event, whereas constrictive pericarditis is a chronic process developing over months to years. Therefore, pericardial disease management is challenging for most clinicians. The evidence base in the field is relatively scarce compared with other disease entities in cardiology. European Society of Cardiology released guidelines for the diagnosis and management of pericardial diseases. Currently there are no guidelines from American cardiology societies to help clinicians in dealing with pericardial disease. In this book, my goal is to provide extensive review of pericardial disease evaluation and management. A unified, stepwise pathway-based approach for the management of pericardial disease is provided at the end of the book.

M. Gabriel Khan, MD, concisely assembles in a reader friendly format all the clinically useful information that an internist needs in both his daily rounds and abusy office practice to find correct clinical diagnoses and choose optimal pharmacologic therapies for their patients. Highlights include a simplified method for recognition of, and a practical therapeutic approach to, arrhythmias, as well as a more logical approach to drug management of hypertension than that given by the Joint National Committee, instructive algorithms that simplify the diagnosis and treatment of syncope, and extensive diagnostic information on hypertrophic cardiomyopathy. A large number of illustrative electrocardiograms that help to clarify the most often misinterpreted of all cardiologic tests and extensive discussions of practical cardiovascular pharmacology complete this magisterial survey.

Following the tradition of its predecessor, the fifth edition of Nutrition: Maintaining and Improving Health continues to offer a wide-ranging coverage of all aspects of nutrition while providing new information to this edition including: Increased coverage of experimental and observational methods used in nutrition In-depth focus on the nutritional implications of the increased adoption of vegetarian and vegan lifestyles Streamlined referencing - a short selected list of key references at the end of each chapter with URL links to free additional resources where possible Discussion of nutrition debates Critical coverage of "medicinal uses of food" including superfoods, functional foods and dietary supplements Updated bullet point summaries of key points after each major topic within each chapter The author provides an evidence-based evaluation of many key nutrition beliefs and philosophies. The book contains in-depth and critical reviews of the methods used to evaluate nutritional intakes/status and the observational and experimental used to investigate putative links between dietary factors and health outcome. It covers the role of food as a source of energy and nutrients while discussing the non-nutritional roles of food and the social and psychological factors that influence food choice. Presenting a critical discussion on the value of nutrition research linking specific foods or nutrients to specific diseases which encourages students to question the value of some current nutrition research. This is essential reading for all nutrition and dietetics students with different backgrounds who are studying nutrition as a specific discipline for the first time.

"Practical Cardiovascular Hemodynamics" provides an in-depth understanding of waveforms and tracings seen in various disease states as well as pathophysiology behind those findings. Practical issues that are rarely discussed or focused upon in textbooks are highlighted in this book with detailed waveform analysis. Pitfalls in the hemodynamic assessment of valvular diseases, constriction, tamponade, pulmonary hypertension, shunt pathology, congenital heart disease, coronary disease, and right and left ventricular failure are provided.

"Practical Cardiovascular Hemodynamics" also includes case-based and tracingbased self-assessment problems. e reader will learn to identify disease states and waveform subtleties from single tracings or from case studies and will increase skills in interpreting tracings, understanding notches and artifacts, and formulating a diagnosis.

"Practical Cardiovascular Hemodynamics" Features: Complete presentation of basic and advanced hemodynamics Numerous case studies allow the reader to learn real-life application of hemodynamic data in clinical decision making Questions and explanations provides the reader with self-assessment and problem-solving skills 325 illustrations and 25 tables with detailed legends allowing for illustrated learning

This book reviews the surgical management of patients with aortic disease, revealing many options open to cardiovascular specialists in this often controversial area of management. It reviews each controversy and provides clinical information for cardiac surgery, and discusses the spectrum of disorders and their management. With the knowledge base in this discipline changing rapidly, Controversies in Aortic Dissection and Aneurysmal Disease meets an important requirement to consolidate the wide-ranging information on which clinicians must base their practice. It is directed towards surgeons, physicians, and healthcare workers involved in the care of patients requiring cardiac, cardiothoracic and cardiovascular surgery. This book will be an essential resource for these professionals looking to accelerate the translation of basic research findings into clinical study and practice.

Autopsy derives from the greek word autopsia, which means act of seeing with one's own eyes. It remains the most objective and accurate method to understand human. disease. Unfortunately, the volume of autopsies in teaching hospitals has decreased dramatically over the past years. The crucial factors that account for this are the recent progress and development of new technologies, especially in diagnostic imaging, immunology, cell biology and genetics. Additionally, the perpetual fear of legal liability by physicians accounts for its further decline. Consequently, physicians and medical students are engaged in fewer autopsies and are not reaping the rich educational rewards that accompany these examinations. The purpose of the autopsy is not only to establish the cause of death, but also to determine the nature and course of the disease process. Our goal with this book is to emphasize the importance of the post-mortem exam and the correlation between pathologic material and clinical data by analyzing actual cases with problem-based methodology. The focus of this handbook is on cardiovascular disease, and when appropriate, other disease categories are included if they have an impact on cardiovascular function. The approach is more than the usual clinico-pathological correlation. Rather, we attempt to present the material from the perspective of the autopsy table. We use the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition.

Injured mammalian hearts do not regenerate but scar. This is a major medical problem, as ischemic heart disease is among the leading causes of morbidity and mortality worldwide. Essential clues for human heart repair are uncovered when zebrafish and newt are found to regenerate cardiac muscle after injury. This book presents the major advances of the last decade in the field of cardiac regeneration. These recent advances include: demonstration that zebrafish, a genetically tractable system, can regenerate heart; the identification of several new stem cell populations in the heart; demonstration that stem cells can be used to improve heart function; and demonstration that induction of cardiomyocyte proliferation is a realistic future option to repair injured hearts. This book also provides detailed reviews of the research on model organisms capable of heart regeneration as well as innovative translational research to achieve regeneration in mammals, that comprises work on blood born stem cells, endogenous cardiac stem cells, paracrine factors, reawakening of cardiomyocyte proliferation, and bioengineering. More importantly, the book, in the concluding chapter, dovetails the studies with a comprehensive overview of clinical trials.

Ensuring the safety of new medical products remains a major challenge for the pharmaceutical industry. Cardiac safety, particularly drug-induced heart rhythm abnormalities, remains an important cause of pipeline attrition and has resulted in countless major product recalls or label changes. The risk of encountering this major adverse event continues to shape the drug development and regulatory landscape.Extensive research over the past decade has shed light on the root causes of arrhythmias that are triggered by medications and has helped drive, and optimize, drug safety testing. However, current cardiac safety platforms have several limitations and there remains a pressing unmet need to improve the predictive power of today's drug safety tests.Fundamental to addressing the problem of drug-induced arrhythmias, and to reducing the impact of this safety signal on drug development, is a complete understanding of how these events may arise, what cardiac safety tests are currently used, and what opportunities there are to enhance patient safety and reduce the risk of detecting cardiac toxicity in later stages of product commercialization. By introducing the reader to these core concepts, this book delivers key insight into the increasingly important and dynamic field of cardiac safety.

A collection of 200 high quality ECGs (Electrocardiogram's) that cover the entire spectrum of emergency electrocardiography. The first half of the book represents an intermediate level of difficulty and is ideal for residents in training and for the emergency medicine board review. The second half contains more advanced ECGs and will challenge even the most seasoned emergency medicine practitioner. When taken in its entirety, the book contains one of the best collections of ECGs ever assembled, targeted at advancing the ECG interpretation skills of emergency physicians and other acute health care providers.

This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This second volume is focused on all aspects concerning "secondary risk factors" in terms of diseases associated with enhanced risk for cardiovascular events. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.

Heart failure is a major, cause of death worldwide, most frequently secondary toacardiomyopathicdisorder. The rolesofviruses, immunity, cytokines and genetics as sources of heart failure have been relatively understated in the rapidly developing world of clinical cardiology. Yet, great progress in molecular biology and the recent application of new techniquesto studiesoftheetiologyandpathogenesisofcardiomyopathies and heart failure has shed new light in an area ready to undergo major developmentsandadvances. This book is an effort to present an up-to-date account of eXIstmg knowledge,includingrecentdevelopmentsinthisfield. Chapterscovering severaldisciplinesincludingbiochemistry,immunology,molecularbiology, virology,epidemiologyandclinicalmedicinehavebeenincluded,offeringa "bench-to-bedside"and"bedside-to-bench"criticalreviewofeveryaspects of heart failure and cardiomyopathies, by world renowned, expert researchers and clinicians. These opinion leaders review all significant advances in our understandingofheart failure and cardiomyopathies, and describe theimprovements indiagnosis and treatment that areexpectedto optimize the overall management of patients. The identification of establishedornewlyrecognizedmolecules,cytokines,viruses,andgenes,as well as an understandingofthe mechanisms by which these factors may cause cardiomyopathic disorders and induce heart failure depends on a multidisciplinaryapproachwhichthisbookattemptstouniquelyencompass. Therefore,wehopethatitwillbeanimportantresource,notonlyforclinical cardiologists,butalso forgeneralpractitioners,pediatriciansandspecialists in infectious diseases, as well as trainees and graduates in biochemistry, immunology, genetics, molecular biology, virology, pharmacology, and epidemiology. AkiraMatsumori,MD,PhD Ie INTRODUCTORYCHAPTER CARDIOMYOPATHIESANDHEARTFAILURE Biomolecular,InfectiousandImmuneMechanisms AkiraMatsumori,MD,PhD DepartmentofCardiovascularMedicine KyotoUniversityGraduateSchoolofMedicine Kyoto,Japan 1 SUMMARY Theclinicalpresentationofviralmyocarditisisvariable. Whenmyocardial necrosis is diffuse, congestive heart failure develops, and later, dilated cardiomyopathy. If the myocardial lesions are localized, a ventricular aneurysmforms. Whencomplicatedbyarrhythmias,myocarditispresentsas arrhythmogenic right ventricular cardiomyopathy. When myocardial necrosisislocalizedtothesubendocardialregion,restrictivecardiomyopathy may develop. While it has not been established that hypertrophic cardiomyopathy maybeacomplicationofviral myocarditis, asymmetrical septal hypertrophy has, in fact, sometimesbeen observed in patients with myocarditis. TheimportanceofhepatitisCvirusinfectionhasrecentlybeen notedinpatientswithmyocarditis,dilatedandhypertrophiccardiomyopathy.

Recent years have seen numerous advances in cardiovascular nuclear medicine technology, leading to more precise diagnoses and treatment and an expanded understanding of the molecular basis for cardiac disease. Nuclear Cardiology and Multimodal Cardiovascular Imaging is a one-stop, comprehensive guide to the diagnostic and clinical implications of this complex and increasingly important technology. Part of the Braunwald family of renowned cardiology references, it provides cutting-edge coverage of multimodal cardiac imaging along with case vignettes and integrated teaching content-ideal for cardiologists, cardiology fellows, radiologists, and nuclear medicine physicians. Features all the latest cardiovascular nuclear medicine studies with practical, evidence-based implications for personalized patient evaluation and treatment. Presents a consistent, patient-centered approach using integrated case vignettes correlated with specific nuclear medicine imaging findings. Discusses patient assessment criteria, risk factor criteria, pathology, evaluation criteria, outcomes, and other clinical implications. Covers a full range of imaging technologies, including SPECT/CT, PET/CT, and CT/MR hybrid radionuclide cardiovascular imaging studies. Addresses emerging clinical applications of nuclear imaging techniques for precision-based medicine, including targeted molecular imaging and cell therapies. Includes sections on instrumentation/principles of imaging; protocols and interpretation; applications in coronary artery disease, special populations, and heart failure; artificial intelligence, and more. Contains guidelines and appropriate use documents to provide appropriate context for clinicians. Features hundreds of high-quality figures including multimodal cardiac imaging studies, anatomic illustrations, and graphs. Provides Key Point summaries, 50 procedural videos, and 100 multiple-choice questions and answers to reinforce understanding and facilitate review. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

A new volume in the Weil Integrative Medicine Library, a groundbreaking series under the general editorship of Dr. Andrew Weil, Integrative Cardiology offers a new and much-needed perspective in cardiac care and prevention, blending conventional medicine with alternative approaches not typically part of the Western medical curriculum. This unique perspective highlights specific gaps in conventional heart care, and examines how alternative approaches may be ideally suited to address these missed opportunities. The book introduces topics not typically addressed in conventional cardiology texts including: nutritional therapies, exercise, botanicals, mind/body approaches, spirituality, aspirin, metabolic cardiology, acupuncture, and energy medicine. The focus of this work is on prevention and it recommends an approach that emphasizes the collaboration of the patient and health care provider--both seeking to obtain the best possible outcome taking into account the intangible, but vital, nuances of the patient's culture, beliefs, and preferences.The contributors, all of whom have a background in academic medicine, share the approaches that they have found most effective in their own practices, basing their work on the best scientific evidence available.

Fully updated from cover to cover, Zipes and Jalife's Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need-from new knowledge in basic science to the latest clinical advances in the field. Drs. Jose Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. Packs each chapter with the latest information necessary for optimal basic research as well as patient care. Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. Includes 47 new chapters covering both basic science and clinical topics. Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. Recipient of a 2018 Highly Commended award from the British Medical Association. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Cardiology is becoming an increasingly complex field understood by only a select group of medical specialists. This publication demystifies many difficult topics in interventional cardiology and cardiac catheterisation, commencing with the basics of laboratory instrumentation and technology and progressing to a comprehensive review of both new and established cardiac interventions. Unlike other publications that are directed mainly towards clinicians, this text is specifically written to assist newcomers such as such as medical trainees, nurses, technicians, scientific staff and other allied health professionals understand the wonders of interventional cardiology, and includes extensive explanations of the techniques of angiography, and new percutaneous. The comprehensive information presented herein, written by recognised specialists in their respective fields, will no doubt prove of great benefit to clinician and non-medical specialist alike.

Chronic pain places a tremendous burden on both the patient and the healthcare system. The use of opioids to address pain has resulted in negative impacts. As practitioners work to undo the current opioid crisis, options to manage pain need a new approach. Advanced Therapeutics in Pain Medicine offers pioneering approaches to this intransigent problem providing a functional medicine approach toward treating pain. This book is dedicated to the advancement of non-opioid therapeutic options that offer real progress in reaching a future of better pain management. With an emphasis on pathophysiology, chapters review various types of pain and propose comprehensive treatment plans. These include manual therapies, novel pharmacologic and plant-based approaches, hormonal effects on pain pathways, as well as psychological and lifestyle interventions. Features * Written by a multi-discplinary team, the book provides clinicians with multiple non-opioid treatment considerations. * Enables practitioners to shift from a "one size fits all' treatment approach toward individualized patient care. * Includes case studies to help educate the provider on how to implement treatment plans in practice. Written by a team of physicians, pharmacists, psychologists and researchers, this important book offers a much needed step forward in optimizing pain care and benefits practitioners who care for patients experiencing chronic pain.

From patient selection and monitoring to follow-up care, Carotid Interventions is the first source to offer a practical how-to approach to carotid angioplasty and stenting-providing maneuvers and strategies for difficult situations, as well as step-by-step guidance on specific surgical procedures, equipment selection and instrumentation, protection devices, and room/facility layout.

Although it is widely recognized that environmental factors such as smoking, diet, exercise, and socioeconomic status affect the risk of cardiovascular disease, recent work showing the effects of other environmental factors provides a more complete assessment of the situation. This view has emerged from three developments. Firstly, there has been a sudden explosion in the prevalence of diabetes and obesity which indicates a strong environmental component. Secondly, there is an accumulation of evidence suggesting that most cases of these diseases could be prevented by healthy lifestyle choices. Finally, studies have shown that exposure to environmental pollutants has a significant effect on heart disease risk. This book is the first to provide a comprehensive account of the effects of pollutants on heart disease and to integrate this area of research within the overall theme of environmental cardiology. The introductory chapter outlines the effects of different aspects of the environment on heart disease and provides a context for the discussion that follows. Subsequent chapters give an overview of the effects of particulate matter and discuss the epidemiological studies supporting the link. The book then goes on to cover the effects of pollution on different aspects of cardiovascular disease (hypertension, stroke, heart failure, ischemic heart disease and atherogenesis). Because of a close association between diabetes and heart disease, a discussion of the effects of particulate matter on diabetes is also included. Later chapters discuss the effects of individual pollutants such as vehicular emissions, metals and aldehydes. A review on manufactured nanoparticles is incorporated because these particles represent an important new threat to cardiovascular health. The understanding that emerges from this monograph suggests that we must be more alert to the effects of the environment and develop strategies that target, not only the diseased individual, but also the unhealthy, disease-causing environment. It is essential reading for cardiologists, epidemiologists, urban planners and pollution control specialists.

100 Challenges in Cardiology comprises one hundred well-illustrated clinical scenarios covering a wide spectrum of cardiology cases hypertension, stable and unstable angina, non-ST elevation and ST-elevation myocardial infarction, coronary intervention, percutaneous aortic and mitral valve treatment, ASD closure, complications of MI, valvular heart disease, pericardial disease, cardiomyopathies, HOCM ablation, haemodynamic assessment in catheterisation laboratory, aortic dissection, infective endocarditis and its complications. Cardiac pacing, arrhythmia diagnosis and management, electrophysiology, CT and MRI scans, and transthoracic and transoesophageal echocardiography images are also included for interpretation. This book will serve as an ideal study aid for medical students and junior doctors who are preparing for their clinical examinations in medicine as it presents the relevant investigations corresponding to each case in an interesting and easy-to-read Q&A format concerning diagnosis and management. This text will also be particularly useful for clinical fellows and specialist senior house officers and registrars who are training in cardiology and its subspecialties. By solving the problems posed by these challenging cases, the reader will gain additional knowledge as well as extra practice in diagnosis and treatment strategies in this exciting specialty of cardiology. Readership: Medical students and junior doctors who are preparing for clinical examinations; clinical fellows, specialist senior house officers and registrars who are training in cardiology; general physicians; general practitioners; ancillary and technical staff in cardiology.

The book represents a paradigm shift from the traditional static model of investigation of oxidative biology to the dynamic model of vascular oxidative stress. The investigation of vascular biology and cardiovascular medicine is made possible by the use of fluid dynamics, molecular signaling, genomic approach, tissue engineering, stem cell biology, and microfluidics. This is the first book to target a wide readership from academia to industry and government agencies in the field of cardiovascular diseases.

James C. Fang, MD, and Gregory S. Couper, MD, have assembled a panel of prominent surgeons and cardiologists to review the latest clinical, scientific, and investigational surgical and mechanical approaches to heart failure in hopes of improving the lives of this challenging group of patients. Topics range from such traditional strategies as high-risk surgical revascularization in advanced coronary artery disease, to more novel approaches such as ventricular reconstruction and mechanical assist devices. Many chapters are contributed by the original pioneers of specific surgical techniques, which provide s invaluable perspective from personal experience.

Ancestral Diets and Nutrition supplies dietary advice based on the study of prehuman and human populations worldwide over the last two million years. This thorough, accessible book uses prehistory and history as a laboratory for testing the health effects of various foods. It examines all food groups by drawing evidence from skeletons and their teeth, middens, and coprolites along with written records where they exist to determine peoples' health and diet. Fully illustrated and grounded in extensive research, this book enhances knowledge about diet, nutrition, and health. It appeals to practitioners in medicine, nutrition, anthropology, biology, chemistry, economics, and history, and those seeking a clear explanation of what humans have eaten across the ages and what we should eat now. Features: Sixteen chapters examine fat, sweeteners, grains, roots and tubers, fruits, vegetables, and animal and plant sources of protein. Integrates information about diet, nutrition, and health from ancient, medieval, modern and current sources, drawing from the natural sciences, social sciences, and humanities. Provides comprehensive coverage based on the study of several hundred sources and the provision of over 2,000 footnotes. Presents practical information to help shape readers' next meal through recommendations of what to eat and what to avoid.

This groundbreaking book weaves together three important themes. It describes major developments in the diagnosis and treatment of heart disease in the twentieth century, explains how the Mayo Clinic evolved from a family practice in Minnesota into one of the world's leading medical centers, and reveals how the invention of new technologies and procedures promoted specialization among physicians and surgeons. Caring for the Heart is written for general readers as well as health care professionals, historians, and policy analysts. Unlike traditional institutional or disease-focused histories, this book places individuals and events in national and international contexts that emphasize the interplay of medical, scientific, technological, social, political, and economic forces that have resulted in contemporary heart care. Patient stories and media perspectives are included throughout to help general readers understand the medical and technological developments that are described. The book is a synthetic study, but it is written so that readers may pick and choose the chapters of most interest to them. Another feature of the book is that readers may follow the stories without looking at the notes. Those who are interested in delving deeper into the main topics will find a wealth of carefully chosen references that offer greater detail and additional perspectives. The descriptions and interpretations that fill the book benefit from the fact that the author has been a practicing cardiologist and medical historian for almost four decades. This is mainly a twentieth-century story, but it begins earlier-before physicians who were identified as cardiologists, a time when medical specialization was just emerging in America. The final chapter, which addresses present-day concerns about health care costs, counterbalances earlier ones that might be read as celebrations of new technologies.