Dr Shor believes it is important for every medical practitioner to be aware of the new aspects of this disease, and that all facts concerning the circumstances, the finding of the germ, the specific pathological features and other aspects which change the concept of heart attacks, remarkably, methods of diagnoses of the lesion should all be known. Details and facets of the lesion are necessary for assessment, acceptance or rejection of this very important new disease, by the scientific community. It opens up new diagnosis and treatments, with potential cure and eradication of this deadly disease. Immunization or eradication of this germ if possible will open new horizons.

Outlines the basics of nutrition for healthcare professionals. Directed towards an international audience; written from the holistic perspective. There has been a definite shift in our perception and understanding of foods and diet. More attention is being given towards how we grow and cultivate food sources whilst being mindful about the environmental impact this may have - this book is timely, the medical community is now giving due importance to dietary content.

Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility provides cutting-edge information and solutions to help support the worldwide rise of fertility challenges. It addresses common, yet not commonly known, root-causes of oxidative stress that are at the heart of reproductive issues (and all chronic health issues). These solutions can help enhance the outcomes of Assisted Reproductive Technologies (ART) or support women to avoid them altogether. Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility will show you how to improve cell health (including egg and sperm), lower inflammation, balance nervous system functioning, and optimize genetic expression, allowing the body to return to its naturally fertile state. It details information on numerous root causes of health-derailing inflammation and oxidative stress, while the appendices discuss the genetic and biochemical pathways related to these topics. Each chapter also provides easy "Action Steps" that can be implemented immediately. Chapter topics include iron dysregulation; oxalates; mold/mycotoxins; phase 2 liver detoxification pathways; fat utilization; introductory information on genetics, epigenetics, and nutrigenomics; everything one needs to know about histamine intolerance; and how these factors adversely affect metabolic and reproductive functions. Enhancing Fertility through Functional Medicine: Using Nutrigenomics to Solve 'Unexplained' Infertility is the handbook for people wanting to achieve and sustain a healthy pregnancy. It highlights lesser-known causes of fertility challenges the reader can learn how to investigate. This book also serves as a reference guide for practitioners, providing them with additional tools to add to their repertoires when other protocols have not been effective. It may also provide clarity as to why other protocols did not work, and will enable the practitioner to custom-tailor protocols for each patient.

Leslie T. Cooper, Jr., MD, and a panel of leading clinical and scientific experts comprehensively review both advances in basic scientific understanding and current clinical knowledge of inflammatory heart disease. On the clinical side they discuss the diagnosis, prognosis, and treatment of nonspecific and specific myocarditis in separate chapters devoted to such major idiopathic clinical entities as cardiac sarcoidosis, giant cell myocarditis, eosinophilic myocarditis, Chagas disease, rheumatic fever, and human immunodeficiency virus-related cardiomyopathy. Research articles complete the picture with discussions of the role of apoptosis in viral myocarditis, rat and mouse models of autoimmune giant cell and lymphocytic myocarditis, and the latest available data on enteroviral proteases and cardiomyopathy.

1. Platelet activation and aggregation: rationale for combining antithrombotic drugs.- 2. Role of nitric oxide in endothelial cell - platelet interactions.- 3. Platelets and megakaryocytes in vascular disease.- 4. Thrombosis in relation to atherosclerosis.- 5. Pharmacological inhibition of the ADP-GP IIb/IIIa-fibrinogen pathway of platelet aggregation.- 6. Calcium fluxes in platelets and endothelial cells, mechanisms and functional significance.- 7. Inhibition of platelet function by cyclic nucleotides and cyclic nucleotide-dependent protein kinases.- 8. Pharmacological modification of platelet-derived cyclooxygenase product formation and its consequences for platelet-vessel wall interactions.- 9. Antithrombotics and the lipoxygenase pathway.- 10. Pathological expressions of platelet-vessel wall interactions: implications of serotonin.- 11. The involvement of PAF in thrombotic events.- 12. Prostaglandins and -analogs in the treatment of platelet-vessel wall interaction.- 13. Adjuvant agents to enhance and sustain reperfusion with t-PA: studies in experimental dog models.- 14. Effect of dietary marine lipids on (anti-)thrombotic mechanisms.

The development of a bio-engineered pacemaker is of substantial clinical and also scientific interest because it promises to overcome several limitations of electronic pacemakers. Moreover it may answer the longstanding question of whether the complex structure of the sinus node is indeed a prerequisite for reliable pacemaking, or simpler structures might work as well.

This book gives an overview of the current state-of-the-art of creating a bio-engineered pacemaker. It shows the approaches to develop of genetic and cell-based engineering methods suitable to implement them with safety and stability. It also illuminates the problems that need to be solved before bio-pacemaking can be considered for clinical use.

In this book the authors review the field and explore the potential role of RNAi and other RNA technologies in cardiovascular medicine and research. They highlight the impressive recent progress but also the hurdles that still must be overcome before this promising technology is finally ready for translation and clinical use.

This book provides methodological information on establishing reliable and reproducible experimental models of cardiovascular diseases. Chapters detail practical protocols from expert laboratories focusing on cardiovascular research, leading to novel discoveries in cardiac biology, and the development of effective therapeutic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Experimental Models of Cardiovascular Disease: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Easy-to-use, handheld echocardiographic equipment has recently become a reliable, faster, lower-cost initial assessment option for cardiologists and other healthcare providers. Point-of-Care Echocardiography: A Case-Based Visual Guide clearly explains and demonstrates how to incorporate and effectively employ this new technology in your practice. Real-life images from actual outpatient consultations and in-patient evaluations provide step-by-step guidance on using handheld echo to arrive at a definitive diagnosis and/or to exclude other possible diagnoses. Focuses on the use and application of the latest handheld echocardiography devices for screening and initial diagnosis at point of care. Includes clinical case studies with history, physical exam, a wide range of normal and abnormal laboratory, ECG and imaging findings along with multiple images and video clips obtained with handheld system by an expert cardiologist. Features 169 echocardiographic images and 48 videos depicting use of point-of-care echo and its cardiovascular imaging findings. Provides an overview of cardiac and vascular anatomy and physiology and imaging techniques, tips, nuances, and limitations of handheld systems. Covers normal and abnormal findings and when to refer for further study. Discusses and demonstrates how to perform transthoracic echocardiography for assessment of cardiac and valve function, intravascular volume, ultrasound imaging to detect pericardial and pleural effusion, during pericardiocentesis and imaging assessment of vascular connections to the heart. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures and videos from the book on a variety of devices.

Since the introduction of myocardial perfusion imaging and radionuclide angiography in the mid-seventies, cardiovascular nuclear medicine has undergone an explosive growth. The use of nuclear cardiology techniques has become one of the cornerstones of the noninvasive assessment of coronary artery disease. In the past 15 years major steps have been made from visual analysis to quantitative analysis, from planar imaging to tomographic imaging, from detection of disease to prognosis, and from separate evaluations of perfusion, metabolism, and function to an integrated assessment of myocardial viability. In recent years many more advances have been made in cardiovascular nuclear imaging, such as the development of new imaging agents, reevaluation of existing procedures, and new clinical applications. This book describes the most recent developments in nuclear cardiology and also addresses new contrast agents in MRI. What's New in Cardiac Imaging will assist the clinical cardiologist, the cardiology fellow, the nuclear medicine physician, and the radiologist in understanding the most recent achievements in clinical cardiovascular nuclear imaging.

Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.

Noncommunicable Diseases: A Compendium introduces readers to noncommunicable diseases (NCDs) - what they are, their burden, their determinants and how they can be prevented and controlled. Focusing on cardiovascular disease, diabetes, cancer and chronic respiratory disease and their five shared main risk factors (tobacco use, harmful use of alcohol, unhealthy diet, physical inactivity and air pollution) as defined by the United Nations, this book provides a synopsis of one of the world's biggest challenges of the 21st century. NCDs prematurely claim the lives of millions of people across the world every year, with untold suffering to hundreds of millions more, trapping many people in poverty and curtailing economic growth and sustainable development. While resources between and within countries largely differ, the key principles of surveillance, prevention and management apply to all countries, as does the need to focus resources on the most cost-effective and affordable interventions and the need for strong political will, sufficient resources, and sustained and broad partnerships. This compendium consists of 59 short and accessible chapters in six sections: (i) describing and measuring the burden and impact of NCDs; (ii) the burden, epidemiology and priority interventions for individual NCDs; (iii) social determinants and risk factors for NCDs and priority interventions; (iv) global policy; (v) cross-cutting issues; and (vi) stakeholder action. Drawing on the expertise of a large and diverse team of internationally renowned policy and academic experts, the book describes the key epidemiologic features of NCDs and evidence-based interventions in a concise manner that will be useful for policymakers across all parts of society, as well as for public health and clinical practitioners.

I. Clinical Topics.- The Clinical Profile of Sepsis and the Adult Respiratory Distress Syndrome.- The Participation of the Complement System in Atherosclerotic Vascular Disease.- The Spectrum of Atherosclerosis in the Human.- Cerebral Endothelial Injury in Stroke, Brain Trauma and Hypertension.- II. General Concepts in Endothelial Cell Pathophysiology.- Free-Radical Mediated Actions on Endothelial Cells of the Intact Lung.- Regulation of Vascular Function by Vascular Permeability Factor.- III. Chemical Mediators of Endothelial Cell Injury.- Endothelial Cells as Targets for and Producers of Cytokines.- Roles of Vascular Cells in Inflammation and Immunopathology.- The Biochemistry, Cell and Molecular Biology of Type 1 Plasminogen Activator Inhibitor.- IV. Endothelial Cell Interaction with Blood Components.- Purine Regulation of Endothelial Cells: Relevance to Pathophysiology.- Autoantibodies to Endothelial Cells.- Leukocyte-Endothelial Cell Interactions.- V. Vascular Responses to Endothelial Cell Injury.- Endothelial Function in Human Coronary Bypass Grafts.- Altered Renovascular Endothelial Functions During Nephrotoxicity.- Cerebral Endothelial Function: Physiology and Pathophysiology.- Mechanisms of Altered Reactivity in the Cerebral Microcirculation.- VI. Mechanisms of Endothelial Cell Dysfunction.- The Role of Apolipoprotein E and Apolipoprotein B in Atherosclerosis.- Endothelial Cell-Matrix Interactions in Health and Disease.- Biosynthesis and Assembly of von Willebrand Factor by Vascular Endothelial Cells: Relevance to Pathophysiology.- VII. Markers of Endothelial Cell Injury and Repair.- Monitoring of Endothelial Plasmalemmal Ectoenzyme Function as an Index of Endothelial Injury and Repair.- Pathophysiological Significance of Endothelial Cell Integrins.- VIII. Epilogue.- Vascular Endothelium: Physiological Basis of Clinical Problems.- IX. Abstracts of Oral and Poster Presentations.- X. List of Participants.- XI. Index.

Learn to interpret cardiac dysrhythmias and successfully treat patients! Huszar's ECG and 12-Lead Interpretation, 6th Edition uses a step-by-step approach to help you build skills in accurate rhythm interpretation, diagnosis, and clinical management. Correlating ECG interpretation with clinical signs and symptoms, the text begins with basic skills and progresses to more advanced concepts. Hundreds of ECG rhythm strips provide plenty of practice with identifying heart rhythms. Written by experienced EMS physician and educator Keith Wesley, this guide is also ideal for quick reference while on the job, anywhere from the emergency department to the back of an ambulance. Comprehensive review of heart rhythm interpretation reflects current ECC guidelines. Logical organization of material teaches the way in which readers learn specific skills - ECG components are presented first, followed by rhythm interpretation and then clinical applications. Coverage of both basic and advanced concepts incorporates the latest research developments and provides material pertinent to both beginners and experienced prehospital care providers. Recognition of various heart rhythms is promoted by their appearance on the ECG, correlated with the patient's clinical signs and symptoms. Patient care algorithms outline step-by-step management and treatment, correlating ECG interpretation with history and exam findings. Advanced-level treatment content includes complete thrombus formation, treatment, and management. Take-Home Points summarize each chapter, highlighting need-to-know information about the most important topics. Author's Notes provide tips on alternative diagnoses, possible complications of warning signs, normal variations, and more, allowing you to benefit from the author's decades of experience. Expert author Dr. Keith Wesley is a board-certified emergency medicine physician and has been involved in EMS since 1989. Learning features include chapter outlines, learning objectives, key terms, chapter review questions, quick-reference summaries of the key characteristics of each heart rhythm, Drug Caution boxes, and a glossary. NEW! Updated content includes the latest guidelines from the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care and also the International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. NEW! Updated learning features include key definitions, ECG Keys boxes, Take-Home Points, author's notes, chapter review questions, an appendix of more than 250 self-assessment rhythm strips, and an appendix of answers to the chapter review questions.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and around the world. Major risk factors for CVD result from poor lifestyle habits and practices, but the area of lifestyle medicine has emerged to help clinicians and their patients understand the power of positive lifestyle habits and actions. Written by cardiologist and lifestyle medicine pioneer, Dr. James Rippe, Integrating Lifestyle Medicine in Cardiovascular Health and Disease Prevention introduces the principles of lifestyle medicine with the practice of cardiology to help lower the risk of heart disease and, if already present, assist in its treatment. This book provides evidence-based information on both the prevention and treatment of CVD through lifestyle measures such as regular physical activity, sound nutrition, weight management and avoidance of tobacco products. This information aids physicians and patients to better understand multiple linkages between poor habits and practices, employing them with associated behavioral techniques to lessen the likelihood of developing CVD. Features: Summarizes major issues in CVD including heart attack, stroke, atrial fibrillation, high blood pressure, lipid abnormalities and obesity. Provides protocols for overcoming a sedentary lifestyle and using lifestyle medicine techniques to optimize brain health. Empowers clinicians with vital information for consultations on the power of lifestyle medicine practices, both to treat symptoms if already present or to prevent major components of CVD from developing in the future. Written for practitioners at all levels, this user-friendly volume in the Lifestyle Medicine series is valuable to practitioners in general medicine or subspecialty practices including lifestyle medicine and cardiology.

Edited by a renowned scientist in the field with more than 200 high profile scientific publications to his name, this is the first book to provide a comprehensive overview of all cardiovascular hormone systems. Clearly structured, the text covers steroid and peptide hormones, amines, and arachidonic acid metabolites, as well as such others as nucleotides, nitric oxide, and acetylcholine. An essential reference for researchers working on the cardiovascular system and related diseases.

Key Features: 1. Covers existing and emerging issues in cardiovascular disease epidemiology and prevention. 2. Has a multi-disciplinary approach in content and audience. 3. Connects with health systems and relevant sustainable development goals 4. Provides case studies for enabling readers to understand and apply evidence-based solutions to key public health issues. 5. Has inputs from globally renowned public health experts.

In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs. The selection of which model is most idea depends upon precisely what question is being asked. The large number of experimental models used to evaluate antiarrhythmic compounds points out the inability of anyone model to define the probability of antiarrhythmic efficacy in man. It has therefore become standard practice to utilize a batter of animal models for the evaluation of new antiarrhythmic agents. Each model has its own advantages and disadvantages and it is necessary to understand each model fully in oder to evaluate experimental findings and apply them to clinical settings. We believe that the availability of the chronic myocardial infarction ventricular tachyarrhythmia model provides 1) an excellent opportunity to more precisely understand arrhythmia mechanisms, 2) to develop new techniques such as signal averaging for evaluating late low level potentials identifying hearts at high risk of sudden death 3) to identify new antifibrillatory drugs versus drugs that are effective primarily against PVC's and ventricular tachycardia 4) to identify new surgical techniques to eliminate VT/VF, and 5) to evaluate new pacing modalities including implantable cardioverters. Although all animal models are wrong, many are very useful in furthering our knowledge directed at decreasing the distressingly high mortality from heart disease. NORMAL HtART TACHYCMDIA HtART , .. '" \ I I I I I I I I I .

* follows the counseling principle of meeting the client where they are and questions what happens when eating disorder professionals fail to acknowledge veganism as an authentic part of their client's recovery * explores the existing research in conjunction with the ideas perpetuated around veganism and recovery, the potential harm to vegans prohibited from following veganism in treatment centers, and indications of further shifts toward normalizing veganism in the eating disorder field * discusses how to positively impact a vegan's access to treatment, the quality of their treatment, and a professional's capacity to provide optimal treatment to vegans and non-vegans alike

This book provides a guiding thread between the distant fields of fluid mechanics and clinical cardiology. Well rooted in the science of fluid dynamics, it drives the reader across progressively more realistic scenarios up to the complexity of routine medical applications. Based on the author's 25 years of collaborations with cardiologists, it helps engineers learn communicating with clinicians, yet maintaining the rigor of scientific disciplines. This book starts with a description of the fundamental elements of fluid dynamics in large blood vessels. This is achieved by introducing a rigorous physical background accompanied by examples applied to the circulation, and by presenting classic and recent results related to the application of fluid dynamics to the cardiovascular physiology. It then explores more advanced topics for a physics-based understanding of phenomena effectively encountered in clinical cardiology. It stands as an ideal learning resource for physicists and engineers working in cardiovascular fluid dynamics, industry engineers working on biomedical/cardiovascular technology, and students in bio-fluid dynamics. Written with a concise style, this textbook is accessible to a broad readership, including students, physical scientists and engineers, offering an entry point into this multi-disciplinary field. It includes key concepts exemplified by illustrations using cutting-edge imaging, references to modelling and measurement technologies, and includes unique original insights.

Current, comprehensive, and evidence-based, Braunwald's Heart Disease remains the most trusted reference in the field and the leading source of reliable cardiology information for practitioners and trainees worldwide. The fully updated 12th Edition continues the tradition of excellence with dependable, state-of-the-art coverage of new drugs, new guidelines, more powerful imaging modalities, and recent developments in precision medicine that continue to change and advance the practice of cardiovascular medicine. Written and edited by global experts in the field, this award-winning text is an unparalleled multimedia reference for every aspect of this complex and fast-changing area. Offers balanced, dependable content on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. Includes 76 new contributing authors and 14 new chapters that cover Artificial intelligence in Cardiovascular Medicine; Wearables; Influenza, Pandemics, COVID-19, and Cardiovascular Disease; Tobacco and Nicotine Products in Cardiovascular Disease; Cardiac Amyloidosis; Impact of the Environment on Cardiovascular Health, and more. Features a new introductory chapter Cardiovascular Disease: Past, Present, and Future by Eugene Braunwald, MD, offering his unique, visionary approach to the field of cardiology. Dr. Braunwald also curates the extensive, bimonthly online updates that include "Hot Off the Press" (with links to Practice Update) and "Late-Breaking Clinical Trials". Provides cutting-edge coverage of key topics such as proteomics and metabolomics, TAVR, diabetocardiology, and cardio-oncology. Contains 1,850 high-quality illustrations, radiographic images, algorithms, and charts, and provides access to 215 videos called out with icons in the print version. Highlights the latest AHA, ACC, and ESC guidelines to clearly summarize diagnostic criteria and clinical implications. Provides tightly edited, focused content for quick, dependable reference. Flexible format options include either one or two volumes in print, as well as a searchable eBook with ongoing updates. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book gathers multidisciplinary articles that present advances of our understanding of diseases and the effective treatment of patients. The authors share recent clinical and experimental research findings, highlighting poorly understood areas with uncertain treatment outcomes, such as giant-cell bone tumors and their propensity to metastasize to the lungs; subterranean rehabilitation in pulmonary disorders; male reproductive hormone regulation during physical exercise in hyperbaric, hyperoxic environments, like underwater diving; and amelioration of cognitive decline owing to increased cerebral blood transit time after internal carotid artery stenting. Other topics include new concepts and innovations in the treatment of diabetes in pregnancy, and leg ulcers in chronic venous insufficiency, as well as molecular research on the toxic effects of oxidative stress, impaired cell autophagy, and experimental conditions resembling air pollution. Featuring the latest interdisciplinary advances in biomedicine, this book is a valuable resource for medical professionals, both academics and practitioners, and all allied health-care workers.

The field of electrocardiography is at a cross roads. We have reached an era in cardiovascular about the electrical state of the heart not likely to be available in any other imaging techniques. medicine where it is claimed that "imaging" is king. The innovative and useful ultrasound And, in the body surface potential map, we have an imaging technique that goes beyond struc techniques continue to develop, and, in the wings lie magnetic resonance, position emission, ture-the only other being, perhaps, magnetic resonance, which has the potential for metabolic and, perhaps, other modalities. Consequently, there are those who state that, other than the imaging. Clinical electrocardiography is impor problems related to cardiac rhythm, electro tant not only as a diagnostic tool for it can truly cardiography as a discipline is passe. In addi give insight into the effect of the disease in question on the heart muscle itself. tion, although there is continued superb work in the basic science related to arrhythmias, only Therefore, it seemed now to be appropriate to a handful of scientists are interested in the bring together leaders in the various fields of myocardial source per se. And few scientists are electrocardiography with the only constraint interested in what happens to that myocardial being a concentration on newer concepts and electrical source on its trip from the endo ideas.

This book is the first comprehensive overview of the emerging field of cuffless blood pressure monitoring. Increasing clinical evidence proves that longitudinal measurements of blood pressure allow for earlier detection and better management of multiple medical conditions and for superior prediction of cardiovascular events. Unfortunately, today's clinical and industry standards for blood pressure monitoring still require the inflation of a pneumatic cuff around a limb each time a measurement is taken. Over the last decades clinicians, scientists and device manufacturers have explored the feasibility of technologies that reduce or even completely eliminate the need of cuffs, initiating the era of cuffless blood pressure monitoring. Among the existing literature, this book is intended to be a practical guide to navigate across this emerging field. The chapters of the handbook have been elaborated by experts and key opinion leaders in the domain, and will guide the reader along the clinical, scientific, technical, and regulatory aspects of cuffless blood pressure monitoring.