This book elucidates how advances in genomics research are being applied in connection with heart diseases. It describes the development of genome-scale technologies and their applications to all areas of cardiac investigations, such as genomics, functional genomics, epigenomics, etc., and how they relate to a series of important breakthroughs in various heart diseases. Applying unbiased genomics, combined with a disease-focused and hypothesis-driven approach, represents a promising way to advance our understanding of cardiac diseases. The book offers an important reference work on introducing genomics in heart disease for all scientists and graduate students whose work involves genomics and cardiology, as well as for clinical physicians.

Continuing demand for this book confirms that it remains relevant over 30 years after its first publication. The fundamental explanations are largely unchanged, but in the new introduction to this second edition the authors are on hand to guide the reader through major advances of the last three decades. With an emphasis on physical explanation rather than equations, Part I clearly presents the background mechanics. The second part applies mechanical reasoning to the component parts of the circulation: blood, the heart, the systemic arteries, microcirculation, veins and the pulmonary circulation. Each section demonstrates how an understanding of basic mechanics enhances our understanding of the function of the circulation as a whole. This classic book is of value to students, researchers and practitioners in bioengineering, physiology and human and veterinary medicine, particularly those working in the cardiovascular field, and to engineers and physical scientists with multidisciplinary interests.

The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel "myokines" that might act as new therapeutic agents in the future.

A highly clinical, practical book on carotid diseases, which focuses on management options. For each management question an expert from Europe and from the US offer their views, and for particularly controversial topics more than one author has been invited to comment. Conclusions or management options are summarised in a box at the conclusion of each topic, which allows easy referral. The book is divided up into three main parts, covering pre-operative work-up, operative aspects and post-operative care. Chapters include evidence-based recommendations and experts personal opinions and reflect on-going clinical debate.Practical, focussed and clinically relevant. Highlights the most controversial issues with expert opinions on each.Management options summarised for easy referral. An up-to-date summary on the challenging area of carotid disease.Reflects on-going clinical practice. Includes evidence-based information.Covers many practical and controversial issues that are not mentioned in the mainstream textbooks. Includes expert input from 60 experienced clinicians from the US and Europe.Reflects queries and problems faced by surgeons in their day-to-day work.

With a wealth of sound practical advice, from the authors' years of extensive experience, this book will be invaluable for all those prescribing aerobic exercise programmes for cardiovascular health including: general practitioners, physiotherapists, nurses, exercise instructors and advisors.Covers traditional and contemporary approaches Many easy-to-use charts for the calculation of exercise intensities and aerobic exercise programmes Well referenced and thoroughly tested

High blood pressure is a common chronic medical problem encountered in primary care, yet it is commonly under diagnosed. ABC of Hypertension is a long established, practical guide to the investigation, treatment and management of hypertensive patients. This sixth edition: * Provides practical guidance on measurement of blood pressure and the investigation and management of hypertensive patients * Explains new developments in measurement and automated measurement of blood pressure and * Updates coverage on treatment of the elderly and explains of the implications of recent trials * Incorporates current British Hypertension Society and NICE guidelines

Selected as a Doody's Core Title for 2022! For more than 30 years, health care providers have turned to The Only EKG Book You'll Ever Need for Dr. Malcolm S. Thaler's clear and concise guidance on EKG use in everyday practice. Ideal for readers at all levels of experience, the tenth edition of this straightforward, highly visual resource presents must-know information on using an EKG to diagnose cardiac and non-cardiac conditions, with numerous EKG strips, clear illustrations, clinical examples, and case studies throughout. From cover to cover, Dr. Thaler's commitment to "keeping simple things simple and making complicated things easy to understand" helps you learn and understand how to best use an EKG in actual clinical settings. Provides more than 200 EKG strips, including many new to this edition Includes updated clinical scenarios and case studies, step-by-step instructions, newly clarified concepts, and high-quality illustrations throughout Uses a lighthearted, lively writing style designed to be compelling and minimize confusion of principles discussed Outlines processes for identifying and interpreting arrhythmias, myocardial infarctions, hypertrophy, atrial fibrillation, and other disorders Advises on the dangers of over-reliance on computer interpretations and includes many other practical considerations that other books leave out Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.

The Myocardium, Second Edition is a comprehensive presentation of cardiac function, including ultrastructure, cellular development and morphogenesis, ion channels, ion transporters, excitation-contraction coupling and calcium compartmentation, mechanics and force production, and energy metabolism. The Second Edition presents the new molecular, subcellular, and cellular developments which have occurred in this rapidly expanding field during the past 22 years.
Key Features
* Comprehensive overview of all aspects of heart function at the cellular, subcellular, and molecular level
* Integrates molecular events to give understanding of global cardiac function
* Includes basis of important pathological states

Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, and presents the information in a comprehensive and easily accessible manner. The book also contains valuable information on practical applications of basic research.
Key Features
* Presents topics in a comprehensive and accessible format
* Written by international authorities on cerebral vasculature
* Provides practical applications for researchers

Echocardiography Board Review, 2nd Edition 500 Multiple Choice Questions with Discussion Ramdas G. Pai, MD, Professor of Medicine, Loma Linda University, CA, USA Padmini Varadarajan, MD, Associate Professor of Medicine, Loma Linda University, CA, USA Echocardiography is an essential tool for the modern-day cardiologist and routinely used in the diagnosis, management and follow-up of patients with suspected or known heart diseases. This best-selling book now returns in a fully revised new edition, once again providing cardiologists and cardiology/echocardiography trainees with a rapid reference, self-assessment question and answer guide to all aspects of echocardiography. Packed with full-color images and written by experienced echocardiographers, the book covers: * applied ultrasound physics * practical hydrodynamics * valvular heart disease * myocardial diseases * congenital heart disease * non-invasive hemodynamics * surgical echocardiography Containing 500 case-based questions, including clear explanations and discussions for every question, Echocardiography Board Review, 2nd Edition, is the perfect preparation guide for all those about to take the National Board of Echocardiography s Board exam, including cardiology and echocardiography trainees and specialist physicians preparing for re-certification. Sonographers planning to take RDCS or RDMS certification examinations should find this book very helpful as well. Of related interest Practical Manual of Echocardiography in the Urgent Setting Fridman, ISBN 978-0-470-65997-7 Successful Accreditation in Echocardiography: A Self-Assessment Guide Banypersad, ISBN 978-0-470-65692-1 Website www.wiley.com/go/cardiology

The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects. It firstly describes the general aspects of exosomes including the definition, formation and secretion of exosomes and highlight their roles as biomarkers and pathological and therapeutic effects in cardiovascular diseases as well. Secondly, basic aspects of exosomes including the purification methods of exosomes, exosomes content, and functional roles of the cardiovascular exosomes are summarized. Thirdly, exosomes as biomarkers of cardiovascular diseases are overviewed including their roles in diagnosis, prognosis and reaction to therapy. Fourthly, pathological effects of exosomes and therapeutic effects of exosomes are highlighted. Finally, future prospects of exosomes in cardiovascular research would be provided. This is an essential reference for researchers working in cell biology and regeneration, as well as clinicians such as cardiologist.

This book reviews the surgical management of the mitral and tricuspid valves. It provides a detailed examination of the recent exponential improvements in the understanding of the pathophysiology of the disease processes affecting these valves, which has resulted in significant changes in the strategies that can be applied. Chapters include analysis of the basic sciences related to the anatomy and physiology of the mitral and tricuspid valves, pre-operative imaging of these valves, illustrating the variety of pathologies encountered, and critically a comprehensive step-by-step approach to the peri-operative management and surgical techniques pertaining to each pathological process. Operative Mitral and Tricuspid Valve Surgery systematically covers all major topics involved in the current practice of an adult cardiac surgeon who performs operations on the mitral and tricuspid valves. It is therefore suitable for the cardiac intensive care unit specialist interested in improving their knowledge of cardiac patient management. It is an essential resource for all adult cardiac surgeons and cardiac intervention specialists at any stage of their career.

This unique book details a multidisciplinary approach for providers caring for the Mechanical Circulatory Support (MCS) patient. Authors discuss the history of MCS, patient selection, surgical and post-operative care, mobility and nutritional issues for this subgroup of patients, along with outpatient management. They are expert clinicians in the field of MCS and Extracorporeal Membrane Oxygenation (ECMO), who provide direct patient care, conduct research, publish and maintain current leadership positions within the International Society of Heart and Lung Transplant and International Consortium of Circulatory Assist Clinicians.Non-clinical issues including Regulatory, Reimbursement, Administration, Program Development and links to Professional Organizations supporting MCS Clinicians are presented in the book that will be of great value to Nurses first, but also to Advanced Practice Providers (NP/PA), Dieticians, Physical Therapists and Administrators.

When treating hypertension, physicians now have a huge range of drugs from which to choose in formulating a management strategy. This accessible guide helps the busy clinician access specific information on available drugs as components of an integrated care plan.

The "Handbook of Hypertension" is a comprehensive review of the evidence base for hypertension and associated disease, providing tables, figures, charts, and summaries of principal findings from clinical studies on hypertension - putting vital information within reach of the busy practitioner.

Containing the most recent guidelines for global cardiovascular risk analysis and evidence-based reviews on important new advances and recent trials, consulting the "Handbook of Hypertension" will save precious time and improve patient care.

This book reflects how the concern regarding the effects of radiation exposure in patients and health personnel involved in cardiac electrophysiology (EP) has inspired new developments in cardiac electrophysiology procedures without the use of fluoroscopy. This innovative method has become a subspecialty within electrophysioloy with several EP laboratories around the world adopting an exclusive non-fluoroscopy approach. It features guidance on how to use three dimensional (3D) navigation systems, ablation energy sources and zero-fluorospic implantation of cardiac electronic devices. The potential complications and associated preventative methods with utilising RFCA are also described. Cardiac Electrophysiology Without Fluoroscopy offers a thorough description of the technique correlated to the performance of EP procedure without the use of radiation, and provides a valuable resource for those seeking a practically applicable guide on how to perform cardiac EP without fluoroscopy, including practising and trainee electrophysiologists, cardiac imagers, general cardiologists and emergency medicine physicians.

Providing optimal care for heart failure patients is a complex challenge that requires cooperation and coordination across multiple disciplines. Now, you can apply the successful techniques pioneered at the Cleveland Clinic, which are carefully explored and explained in this text.
Drs. McCarthy and Young draw on their experience to show how an interdisciplinary team works together to:
* arrive at a proper diagnosis
* initiate medical therapy
* make decisions regarding the best use of percutaneous therapies, surgical therapies, electrical therapies, and the use of mechanical circulatory support devices and transplantation.
Throughout the book, they present the most updated evidence for both drug trials and surgical trials. They emphasize the benefits of performing the most complete surgery that is practical, then continuing medical therapy. Each chapter focuses on one aspect of treatment, but the authors recognize that the best way to manage an individual patient is often to adapt a variety of different therapies. They state their opinions clearly, identifying which part of care is science and which is art.
Heart Failure: A Combined Medical and Surgical Approach is a true collaboration that helps you identify the most effective strategies - operative interventions, pacing and ICD treatment, new diagnostic tools, and pharmacotherapeutic developments - and implement them for your patients.

This volume sets out to consider a range of cardiac diseases for which drugs may play a therapeutic role by virtue of their effects on aspects of the immune system. The book reviews diseases of the heart which may involve an immunopharmacological component, and methods and techniques for the study of physiological and biochemical functions in the heart. An important focus is the immunopharmacology of the coronary vascular endothelium and the role of cellular and biochemical components of the immune system in the pathogenesis of atherosclerosis. The content also includes a review of the use of immunologically relevant agents in the setting of cardiac transplantation from aclinical perspective. Immunotherapy has a definite role to play in cardiology to a greater or lesser extent than other forms of intervention, depending on the type of cardiac disease. Immunopharmacology of the Heart aims to identify and clarify this role and points to potential developments of the future. Immunopharmacology of the Heart is a volume for the SYSTEMS theme of The Handbook of Pharmacology. In common with all other volumes it contains standardized illustrations and terms/abbreviations (glossaries of illustrations and terms published at the back of the volume). Other topics covered include: Leukocytes and their role in ischaemic heart disease. Complement activation. Sudden cardiac death. The stunned myocardium and reperfusion injury.

Atrial fibrillation is a heart condition that causes an irregular and often abnormally fast heart rate. It can cause problems including dizziness, shortness of breath and tiredness and a patient may be aware of noticeable heart palpitations, where the heart feels like it is pounding, fluttering or beating irregularly, often for a few seconds or, in some cases, a few minutes (NHS Choices). This comprehensive guide presents clinicians with the latest developments in the diagnosis and management of atrial fibrillation. Divided into seven sections, the book covers clinical spectrum, diagnosis, therapeutic strategies, interventions, and new technologies used in its treatment and prevention. Complete sections are dedicated to other arrhythmias, to cardiac surgery and to future directions in atrial fibrillation. With more than 1000 pages providing in depth coverage of the topic, this manual is further enhanced by clinical photographs, diagrams and tables. Key Points Comprehensive guide to latest developments in diagnosis and treatment of atrial fibrillation More than 1000 pages discuss clinical spectrum, diagnosis, treatment options, interventions, and new technologies Complete sections dedicated to other arrhythmias, cardiac surgery, and future directions Highly illustrated with clinical photographs, diagrams and tables

Includes coverage of both clinical cardiac pathology and forensic cardiac pathology A user friendly resource with first class text and images, clear and concise Over 600 colour images to aid diagnosis Increased coverage of vascular disease with new chapters on Arteropathies, microcirculation, and vasculitis, and the pericardium

Now in its 4th edition, Kirklin/Barratt-Boyes Cardiac Surgery remains your indispensable source for definitive, state-of-the-art answers on every aspect of adult and pediatric cardiac surgery. This dynamic medical reference thoroughly and systematically covers the full range of new and classic surgical procedures-including the latest alternate and minimally invasive surgical techniques-and presents the up-to-date clinical evidence you need to make effective management decisions. Be certain with expert, dependable, accurate answers for every stage of your career from the most comprehensive, definitive text in the field! Get comprehensive coverage of all areas of cardiac surgery, including ischemic, valvular, and congenital heart disease; cardiac tumors; constrictive pericarditis; thoracic aortic surgery; cardiac transplantation; coronary artery disease; aortic valve disease; cardiac rhythm disturbances; heart failure and transplantation; disease of the thoracic aorta; tetralogy of Fallot; anesthesia; and postoperative care. Stay current with the latest advancements and practices. Comprehensive updates throughout include new information on endovascular management of thoracic aorta disease; new data on clinical outcomes; the most recent minimally invasive procedures; non-invasive CT angiography; new alternative surgical approaches to mitral valve surgery; and many other hot topics! Make the most well-informed decisions and achieve optimal outcomes by exploring each condition's natural history; diagnostic criteria; indications for surgery; operative techniques; and follow-up care. Reference information quickly thanks to a new, streamlined format and easily searchable online access to the complete text, downloadable image library, reference links, and more at expertconsult.com. Visually grasp and better understand critical information with the aid of a new, full-color design that includes an abundance of detailed charts and graphs. Stay current with the latest advancements and practices. Comprehensive updates throughout include new information on endovascular management of thoracic aorta disease; new data on clinical outcomes; the most recent minimally invasive procedures; non-invasive CT angiography; new alternative surgical approaches to mitral valve surgery; and many other hot topics! Reference information quickly thanks to a new, streamlined format and easily searchable online access to the complete text, downloadable image library, reference links, and more at www.expertconsult.com. Master cardiac surgery with the Gold Standard for Cardiac Surgery - the most definitive and clinically comprehensive resource on cardiologic procedures including latest alternate and minimally invasive surgical procedures

This book provides a practical guide to diagnosis and treatment of arrhythmias in children for pediatricians and general pediatric cardiologists. Using multiple ECG examples, the author provides concise descriptions of the key features of each arrhythmia to help the clinician make a diagnosis.

Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and most westernized nations. Both CVDs and their risk factors confer substantial risk for stroke and dementia, but are also associated with more subtle changes in brain structure and function and cognitive performance prior to such devastating clinical outcomes. It has been suggested that there exists a continuum of brain abnormalities and cognitive difficulties associated with increasingly severe manifestations of cardiovascular risk factors and diseases that precede vascular cognitive impairment and may ultimately culminate in stroke or dementia. This second edition examines the relations of a host of behavioral and biomedical risk factors, in addition to subclinical and clinical CVDs, to brain and cognitive function. Associations with dementia and pre-dementia cognitive performance are reported, described, and discussed with a focus on underlying brain mechanisms. Future research agendas are suggested, and clinical implications are considered. The volume is a resource for professionals and students in neuropsychology, behavioral medicine, neurology, cardiology, cardiovascular and behavioral epidemiology, gerontology, geriatric medicine, nursing, adult developmental psychology, and for other physicians and health care professionals who work with patients with, or at risk for, CVDs.

Transoesophageal Echocardiography (TOE/TEE) in cardiac patients is now almost routine. Its use in cardiac monitoring has also extended to include critically ill patients for non-cardiac surgery and the intensive care setting. Specific accreditation is required prior to practice of TOE/TEE involving a written examination and a documented logbook of experience. This book has been specifically designed to help candidates pass the written exam and has been structured around the syllabus. Providing a summary of all relevant information, this is an invaluable study aid. Lists of further reading material are provided with every topic, including guidelines and safety, cardiomyopathies, heart disease, haemodynamic calculations and many more. Each chapter ends with a series of exam-style questions for self-assessment. An extremely useful book for trainee anaesthetists, intensivists, trainee cardiologists and cardiac surgeons.

This book systematically focuses on central sleep apneas, analyzing their relationship especially with heart failure and discussing recent research results and emerging treatment strategies based on feedback modulation. The opening chapters present historical background information on Cheyne-Stokes respiration (CSR), clarify terminology, and explain the mechanics and chemistry of respiration. Following a description of the physiology of respiration, the pathophysiology underlying central apneas in different disorders and particularly in heart failure is discussed. The similarities and differences of obstructive and central apneas are then considered. The book looks beyond the concept of sleep apnea to daytime CSR and periodic breathing during effort and contrasts the opposing views of CSR as a compensatory phenomenon or as detrimental to the failing heart. The diagnostic tools currently in use for the detection of CSR are thoroughly reviewed, with guidance on interpretation of findings. The book concludes by describing the various forms of treatment that are available for CSR and by explaining how to select patients for treatment.

This book covers ACS and Heart Failure, the chapters represent the most current, up to date and knowledgeable content on the topic available. It is written by the worlds most respected leaders in biomarkers, with a majority emphasis on what clinicians need to know. The Editors and their contributors have provided algorithms, annotated case discussions and caveats. They cover biomarkers to predict risk of heart disease, biomarkers of cardiorenal disease , and conclude with a section on new and emerging biomarkers. It be genuinely helpful and practical to those in the field, including not just people working in the field, but nurses, doctors, etc who practice medicine in the clinic, the emergency department and the hospital.