Discoveries in Pharmacology: Volume 1: Nervous system and hormones (2nd Ed.) presents selected articles from the historic Discoveries in Pharmacology series enhanced with commentary from contemporary scholars about the reception and importance of the chapter along with an updated bibliography on the subject with contributions from a Nobel Prize winner and other pioneers in Pharmacology. The Discoveries in Pharmacology series brought acknowledged experts in their fields together to provide first-hand accounts of important pharmacological discoveries discussing the scientific background and stories behind these pivotal moments. They allow a true understanding of the means by which pharmacological discoveries are made. This volume brings forth discussions on key discoveries in psycho- and neuro-pharmacology, haemodynamics, and hormones including chapters on antipsychotic agents by Nobel winner Anders Carlsson, Willy Haefely on benzodiazepine, and butyrophenone-type neuroleptics by P. A. J. Janssen and J. P. Tollenaere. Academic and industry researchers in pharmacology and medicine, as well as advanced students in the area will find this series a useful teaching tool and launch to new discoveries. Chapters can also be used to supplement course material in pharmacology and medical courses. It will also be of interest to those who are interested in the history of medicine.

The developing heart is the first functional organ, and its proper formation and function is essential for life. This volume compiles the exciting new advances that have been made in understanding the regulation of heart development, the genes and pathways involved, and the impact these have in heart disease. A stellar collection of scientists tackles an important facet of heart development, providing a comprehensive set of reviews.
Cutting-edge science Authority of contributors Exciting field of research

Rupture of an abdominal aortic aneurysm is one of the leading causes of death. The risk of rupture has been a controversial topic for years and only recently have population-based studies provided better evidence for clinical management.

This book includes material by an internationally renowned group of authorities directed by a prominent vascular surgeon at Mayo Clinic. The contents represent a well-balanced clinical endovascular approach to the exciting area of vascular medicine and surgery.

"We are living in a period of exciting transformation. The message for anyone interested in the treatment of vascular disease is to embrace the new endovascular techniques -- learn them and improve them. This is the beginning of a new era." A. G. Hakaim

Sudden cardiac death (SCD) is the number one killer in the United States, claiming the lives of more than 300,000 Americans every year. Thus, it is important for heart failure specialists to be knowledgeable about strategies to prevent, manage risk for, and treat conditions leading to sudden cawrdiac death. These topics and more are covered in this issue.

Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world.Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions

This volume contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field."

Computed Tomography (CT) has recently gained in importance in the imaging of the heart.? A basis for the use of CT is provided with articles on normal anatomy as well as anomalies, patient preparation and scanning techniques, and technology and radiation dose reduction strategies.? Evaluation of plaques and stenosis, bypass grafts and stents, and myocardial abnormities and ischemia are reviewed.? Acute chest pain and congenital heart disease are just two of the other topics included in this issue.

This is the first of a three-volume project aimed at providing unique case reports (20 cases per volume) of a large number of supraventricular and ventricular arrhythmias encountered in clinical practice. The book is focused on the treatment of supraventricular arrhythmias, namely focal atrial tachycardias, typical and atypical AVNRT and accessory pathways (both manifest and concealed). All presented-cases were performed using the CARTO electro-anatomical mapping system, which allows the reader to better understand the arrhythmia features due to the high number of images provided. A large number of high-quality figures, which represent the core of the authors' work, enrich the contents: all cases are built around suggestive figures acquired during the patients' hospitalization, which clearly illustrate important concepts used in catheter ablation of cardiac arrhythmias. The figures are not only related to the catheter ablation procedure, but also to the patient history, thus helping the reader to place the invasive treatment of the arrhythmias into clinical context: electrocardiograms, Holter ECGs, signal-averaged ECGs, chest X-Rays, transthoracic and transesophageal echocardiography images, MRI, CT scans, coronary angiography images are provided when considered relevant, in order to better present the patient's condition. Short videoclips with activation maps of the atria or the ventricles during the studied arrhythmia complete the information provided. Teaching-oriented, all chapters include questions and answers and key messages at the end of each case. For this reason, it will be an invaluable tool for cardiologists, clinical cardiac electrophysiologists, and interventional cardiac electrophysiologists in training, but also for all those interested in learning more about the subject.

Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions

This volume contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field.

This book provides readers recent advances on basic research and clinical management of fulminant myocarditis. First chapters introduce aetiology, pathology, and pathophysiology of fulminant myocarditis, in which excessive immune activation and subsequent cytokine storm are proposed to be the core pathogenesis. Following chapters present clinical management of fulminant myocarditis, including clinical manifestations, examinations, and diagnosis of fulminant myocarditis, as well as life support-based comprehensive treatment regimen in acute phase.

Although first reported several decades ago, the combination of ventricular tachyarrhythmias and right ventricular diseases only triggered distinctive attention in recent years. This book covers the whole spectrum of arrhythmogenic right ventricular cardiomyopathies. The reader will find the basic information about the anatomical substrate, the pathophysiologic mechanisms, and the clinical forms. A careful review of the diagnostic tests tackles the numerous available options ranging from the traditional electrocardiogram to the most recent imaging techniques. Also discussed are the therapeutic tools, including drugs, and the nonpharmacologic approaches. With clarifying illustrations, in color when necessary, this book serves not only the specialists in arrhythmias, but cardiologists in general.

Advances in endovascular therapy have allowed interventional radiologists to contribute to the management of visceral arterial aneurysms for not only elective interventions but also for urgent procedures in patients presenting visceral arterial aneurysm rupture. The authors describe and illustrate both imaging diagnosis and endovascular therapy of visceral arterial aneurysm based on their experiences. Transcatheter coil embolisation can provide an alternative method of treatment for both ruptured and non-ruptured visceral arterial aneurysms excluding dissecting lesion that is treated by stent-graft. The authors performed transcatheter coil embolisation in the treatment of 20 non-ruptured visceral arterial aneurysms and 8 ruptured lesions. They have included in this book their data and the implications for treating visceral arterial aneurysms.

Diagnostic accuracy is critical for the identification and treatment of patients with potential cardiac disease. There is now an ever-increasing reliance on the measured levels of diverse proteins (i.e. markers) whose presence in varying amounts can suggest certain cardiovascular pathologies and help to identify optimal therapeutic alternatives. "Cardiac Markers: Current and Future Applications" is designed to familiarize the reader with these concepts, and to facilitate the application of these concepts to patients with cardiac disease.

The chapters in this monograph detail the past, present, and potential future of markers used for the detection of myocardial injury and for risk assessment as part of a cardiovascular disease work-up strategy. The strengths of this extensive overview, written by many of the current leaders in the field, lie in the evidence presented in addressing analytical/technical, clinical, and outcome-assessments of each biomarker currently used in clinical practice, and for those being investigated as potential cutting-edge tools. Clinical cardiologists, pathologists, researchers, and critical and primary care physicians interested in the clinical application of blood-based assays in cardiac patients will all learn from this monograph.

Atrial fibrillation (AF) is the most common sustained arrhythmia, affecting approximately 2.3 million people in the US. One of the most serious side effects of AF is embolic stroke. Technology developed in the last 10 years has made AF treatable and potentially curable. This issue discusses many of the clinical issues in the management of AF, including cardioversion, anticoagulation, and ablation. Also included are current guidelines for treatment and a view of the future.

This easy-to-use manual provides a practical framework for a multi-disciplinary team to deliver a successful cardiac rehabilitation programme.* Despite evidence that cardiac rehabilitation programmes reduce risk, there is no standard for hospital-based multidisciplinary programmes - which are thus complex and costly to design and implement* Based on the cardiac rehabilitation work that has been carried out at in Gloucestershire over the past fifteen years, developing and constantly evaluating the evidence base for the programme* Includes client handouts such as food and exercise diaries

Advances in Cardiovascular Technology: New Devices and Concepts is a comprehensive reference for cardiovascular devices of all types. For engineers, this book provides a basic understanding of underlying pathologies and their prevalence/incidence. It also covers what devices are available, how they are clinically used, and their impact on pathophysiology. In addition, the book presents the constraints imposed on device design and manufacture by the environment in which it is used (e.g., exposure to tissues within the body, blood in particular) and the primary requirements for each specific type of device, including its durability and resistance to fatigue. For clinicians, this book contains information on primary engineering challenges, the types of devices available, their advantages and disadvantages, and the (current and emerging) tools and materials available to device designers.

In the event of an adult cardiac arrest, it is essential to be able to respond rapidly, providing safe and effective care. This new and updated edition of "Advanced Cardiac Life Support" provides the theoretical background to resuscitation as well as explaining the essential resuscitation skills required to manage an adult cardiac arrest- from the time it occurs until subsequent transfer to the ICU.
The emphasis is on the prevention of cardiac arrest with detailed information on the management of peri-arrest arrhythmias and acute coronary syndromes. "Advanced Cardiac Life Support" also discussed ethical and legal issues, record keeping, dealing with bereavement, audit, equipment and training- providing an essential quick reference tool for nurses and health care professionals.An evidence-based approach to emergency care based on the latest Resuscitation guidelinesA succinct yet comprehensive guide to the management of cardiac arrestWritten by an experienced resuscitation training offer who is also a qualified nurse and former CCU Charge Nurse

Selected as a Doody's Core Title for 2022! Providing a solid foundation in current ECG technology as well as the newest diagnostic applications, Marriott's Practical Electrocardiography, Thirteenth Edition, delivers the information you need to quickly improve your ECG interpretive skills. Authors Dr. David G. Strauss and Dr. Douglas D. Schocken offer medical students, residents and fellows a detailed explanation of the ECG, rhythm analysis, and how to rapidly and accurately interpret ECG results. Helpful diagrams, tables, animations, and videos, plus new ECG quizzes online, improve your understanding and skills. Includes new, interactive and topical ECG quizzes available online through the eBook bundled with this text. Offers extensive content updates throughout, including substantial updates to the abnormal rhythms section of the book along with chapters on chamber enlargement, drugs and electrolytes, a new chapter on adult congenital heart disease, and more. Contains summary illustrations with each chapter to that allow you to quickly grasp concepts in an easy-to-understand, telegraphic style. Numerous animations throughout to help illustrate cardiovascular disease processes, their effects on the heart muscle, and their clinical manifestations on ECG readings. Uses ECG recordings, anatomical drawings, glossary terms, and animations, and tables to provide comprehensive guidance on ECG interpretation, with convenience glossaries at the end of each chapter that reinforce key terminology. Pairs diagnostic images with corresponding ECGs to enhance understanding. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This issue of Interventional Cardiology Clinics, guest edited by Drs. Vasilis C. Babaliaros and Adam B. Greenbaum, will discuss Tricuspid Valve Interventions. This issue is one of four selected each year by the series Editor-in-Chief, Dr. Marvin H. Eng. Topics discussed in this issue will include: Anatomy of the tricuspid valve and pathophysiology of tricuspid regurgitation, Imaging of the tricuspid valve: pre-procedural planning and intra-procedural guidance Surgical correction of tricuspid regurgitation, Transcatheter leaflet strategies for tricuspid regurgitation (Tri-Clip and CLASP), Transcatheter annular approaches for tricuspid regurgitation, Other Novel strategies in transcatheter tricuspid valve repair, Approaches to recurrent tricuspid regurgitation following surgical repair or replacement, Orthotopic transcatheter tricuspid valve replacement and Heterotopic transcatheter tricuspid valve replacement. Provides in-depth, clinical reviews on Tricuspid Valve Interventions, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 10 relevant, practice-oriented topics including Echocardiographic Imaging of the tricuspid valve: pre-procedural planning and intra-procedural guidance; CT/MRI Imaging of the tricuspid valve: pre-procedural planning post procedural follow up; Transcatheter leaflet strategies for tricuspid regurgitation (Tri-Clip and CLASP); Approaches to recurrent tricuspid regurgitation following surgical repair or replacement (valve in valve and valve in ring); and more.

Understanding how angiogenesis "works" and how to control it will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently.
* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition
* Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques
* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

This book describes the different aspects of ischemic heart disease, one of the leading causes of death in industrialized countries, and whose growing prevalence represents a major challenge in terms of short- and long-term management and surveillance. This volume offers  a comprehensive discussion of the state-of-the-art diagnostic imaging options, of disease risk stratification, selection of candidates for surgical intervention, percutaneous revascularitation, mechanical assist devices implantation. Recently, the morbidity and mortality of ischaemic heart disease have substantially improved because of the progress in therapeutic strategies, represented by the dramatic evolution of percutaneous coronary interventions, that are carefully described in the volume, together with all the other most recent treatment options:  from medical therapy to conventional surgery, minimally invasive surgery,   surgery of ischemic complications.  The biggest challenge in the next years is, however, to reduce the incidence of coronary artery disease worldwide. This highly illustrated, case oriented reference book is aimed at cardiology fellows in training, while also helpful to surgeons, cardiologists, imaging specialists, interventional cardiologists, as well as other clinicians and students involved in the diagnosis and treatment of ischemic disease.

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. Understanding how angiogenesis "works" and how to control it, will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases.
Angiogenesis cuts across virtually every discipline. The Angiogenesis Foundation identified angiogenesis as a "common denominator" in our most serious diseases. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and many other conditions. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and delayed wound healing.

* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition.
* Provides the "builder's manual" for essential techniques. This is a one-stop shop that eliminates needless searching among untested techniques.
* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

Cardiology is becoming an increasingly complex field understood by only a select group of medical specialists. This publication demystifies many difficult topics in interventional cardiology and cardiac catheterisation, commencing with the basics of laboratory instrumentation and technology and progressing to a comprehensive review of both new and established cardiac interventions. Unlike other publications that are directed mainly towards clinicians, this text is specifically written to assist newcomers such as such as medical trainees, nurses, technicians, scientific staff and other allied health professionals understand the wonders of interventional cardiology, and includes extensive explanations of the techniques of angiography, and new percutaneous. The comprehensive information presented herein, written by recognised specialists in their respective fields, will no doubt prove of great benefit to clinician and non-medical specialist alike.

The rapidly growing population of adults surviving with congenital heart lesions along with the success of interventional cardiology in the child and adolescent has spawned an incredible interest in adapting the technology for the adult congenital patients.

Dr. Mullins, a pioneer in this area, has written an outstanding reference which covers all aspects of performing diagnostic and therapeutic cardiac catheterization procedures on patients of all ages.

This illustrated book details the equipment and techniques for performing safe and successful procedures, with a strong emphasis on avoiding complications. It also includes the requirements of a catheterization laboratory for congenital heart patients, as well as guidance for setting up and operating such a laboratory.

"Cardiac Catheterization in Congenital Heart Disease" serves as an essential manual for pediatric and adult interventional cardiologists worldwide.

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over antiogenesis. Diseases that are angiogensis-dependent result when blood vessels either grow excessively or insufficiently.
* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition
* Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques
* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics